Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | GNF2_CD53 |
| Enrichment Score (ES) | -0.6658818 |
| Normalized Enrichment Score (NES) | -1.7647096 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0721791 |
| FWER p-Value | 0.194 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CORO7 | NA | CORO7 Entrez, Source | coronin 7 | 832 | 2.447 | 0.0022 | No |
| 2 | GIT2 | NA | GIT2 Entrez, Source | G protein-coupled receptor kinase interactor 2 | 2662 | 1.439 | -0.0455 | No |
| 3 | ACTR3 | NA | ACTR3 Entrez, Source | ARP3 actin-related protein 3 homolog (yeast) | 2933 | 1.337 | -0.0375 | No |
| 4 | LIMD2 | NA | LIMD2 Entrez, Source | LIM domain containing 2 | 4411 | 0.881 | -0.0799 | No |
| 5 | MFNG | NA | MFNG Entrez, Source | manic fringe homolog (Drosophila) | 4627 | 0.832 | -0.0766 | No |
| 6 | TRIM22 | NA | TRIM22 Entrez, Source | tripartite motif-containing 22 | 4914 | 0.763 | -0.0769 | No |
| 7 | C17orf62 | NA | C17ORF62 Entrez, Source | chromosome 17 open reading frame 62 | 5267 | 0.672 | -0.0808 | No |
| 8 | INPP5D | NA | INPP5D Entrez, Source | inositol polyphosphate-5-phosphatase, 145kDa | 5714 | 0.576 | -0.0895 | No |
| 9 | WIPF1 | NA | WIPF1 Entrez, Source | WAS/WASL interacting protein family, member 1 | 5979 | 0.531 | -0.0920 | No |
| 10 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 6491 | 0.454 | -0.1047 | No |
| 11 | CORO1A | NA | CORO1A Entrez, Source | coronin, actin binding protein, 1A | 9074 | 0.226 | -0.1963 | No |
| 12 | PAK2 | NA | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 11208 | 0.122 | -0.2729 | No |
| 13 | LCP1 | NA | LCP1 Entrez, Source | lymphocyte cytosolic protein 1 (L-plastin) | 11683 | 0.103 | -0.2889 | No |
| 14 | CSK | NA | CSK Entrez, Source | c-src tyrosine kinase | 12683 | 0.064 | -0.3247 | No |
| 15 | WAS | NA | WAS Entrez, Source | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 13022 | 0.052 | -0.3364 | No |
| 16 | CD48 | NA | CD48 Entrez, Source | CD48 molecule | 13342 | 0.040 | -0.3476 | No |
| 17 | DOCK2 | NA | DOCK2 Entrez, Source | dedicator of cytokinesis 2 | 13996 | 0.015 | -0.3713 | No |
| 18 | ZCCHC6 | NA | ZCCHC6 Entrez, Source | zinc finger, CCHC domain containing 6 | 14810 | -0.013 | -0.4009 | No |
| 19 | GPSM3 | NA | GPSM3 Entrez, Source | G-protein signalling modulator 3 (AGS3-like, C. elegans) | 15135 | -0.027 | -0.4125 | No |
| 20 | PTPRC | NA | PTPRC Entrez, Source | protein tyrosine phosphatase, receptor type, C | 15992 | -0.059 | -0.4430 | No |
| 21 | PTPN6 | NA | PTPN6 Entrez, Source | protein tyrosine phosphatase, non-receptor type 6 | 16067 | -0.063 | -0.4449 | No |
| 22 | CD53 | NA | CD53 Entrez, Source | CD53 molecule | 16512 | -0.081 | -0.4601 | No |
| 23 | SASH3 | NA | 16842 | -0.095 | -0.4709 | No | ||
| 24 | LRCH4 | NA | LRCH4 Entrez, Source | leucine-rich repeats and calponin homology (CH) domain containing 4 | 16978 | -0.100 | -0.4745 | No |
| 25 | ACTR2 | NA | ACTR2 Entrez, Source | ARP2 actin-related protein 2 homolog (yeast) | 18307 | -0.173 | -0.5209 | No |
| 26 | LAPTM5 | NA | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 18352 | -0.175 | -0.5202 | No |
| 27 | CYTIP | NA | 18503 | -0.186 | -0.5232 | No | ||
| 28 | HCLS1 | NA | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 18598 | -0.193 | -0.5240 | No |
| 29 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 19761 | -0.296 | -0.5627 | No |
| 30 | SELL | NA | SELL Entrez, Source | selectin L (lymphocyte adhesion molecule 1) | 21687 | -0.568 | -0.6257 | No |
| 31 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 22044 | -0.636 | -0.6302 | No |
| 32 | GRK6 | NA | GRK6 Entrez, Source | G protein-coupled receptor kinase 6 | 22437 | -0.715 | -0.6350 | No |
| 33 | LSP1 | NA | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 22875 | -0.812 | -0.6402 | No |
| 34 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 23560 | -0.968 | -0.6523 | Yes |
| 35 | TAPBP | NA | TAPBP Entrez, Source | TAP binding protein (tapasin) | 23932 | -1.073 | -0.6515 | Yes |
| 36 | PSME1 | NA | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 23933 | -1.073 | -0.6372 | Yes |
| 37 | ARHGDIB | NA | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 24415 | -1.214 | -0.6385 | Yes |
| 38 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 24433 | -1.222 | -0.6228 | Yes |
| 39 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 25321 | -1.557 | -0.6345 | Yes |
| 40 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 25366 | -1.579 | -0.6149 | Yes |
| 41 | CRLF3 | NA | CRLF3 Entrez, Source | cytokine receptor-like factor 3 | 25409 | -1.595 | -0.5951 | Yes |
| 42 | RPS6KA1 | NA | RPS6KA1 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 25626 | -1.700 | -0.5803 | Yes |
| 43 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 25740 | -1.759 | -0.5609 | Yes |
| 44 | SP110 | NA | SP110 Entrez, Source | SP110 nuclear body protein | 26326 | -2.150 | -0.5535 | Yes |
| 45 | IFI16 | NA | IFI16 Entrez, Source | interferon, gamma-inducible protein 16 | 26475 | -2.276 | -0.5285 | Yes |
| 46 | PSMB8 | NA | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 26617 | -2.405 | -0.5015 | Yes |
| 47 | PSMB10 | NA | PSMB10 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 10 | 26623 | -2.409 | -0.4694 | Yes |
| 48 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 26647 | -2.442 | -0.4375 | Yes |
| 49 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 26685 | -2.482 | -0.4057 | Yes |
| 50 | ELF4 | NA | ELF4 Entrez, Source | E74-like factor 4 (ets domain transcription factor) | 26906 | -2.819 | -0.3760 | Yes |
| 51 | PSMB9 | NA | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 27011 | -3.064 | -0.3388 | Yes |
| 52 | VAV1 | NA | VAV1 Entrez, Source | vav 1 oncogene | 27019 | -3.087 | -0.2977 | Yes |
| 53 | FMNL1 | NA | FMNL1 Entrez, Source | formin-like 1 | 27118 | -3.438 | -0.2553 | Yes |
| 54 | PHF11 | NA | PHF11 Entrez, Source | PHD finger protein 11 | 27141 | -3.511 | -0.2091 | Yes |
| 55 | FXYD5 | NA | FXYD5 Entrez, Source | FXYD domain containing ion transport regulator 5 | 27160 | -3.575 | -0.1619 | Yes |
| 56 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 27181 | -3.688 | -0.1132 | Yes |
| 57 | OSTF1 | NA | OSTF1 Entrez, Source | osteoclast stimulating factor 1 | 27276 | -4.343 | -0.0585 | Yes |
| 58 | STAT6 | NA | STAT6 Entrez, Source | signal transducer and activator of transcription 6, interleukin-4 induced | 27292 | -4.512 | 0.0014 | Yes |
