Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | GNF2_STAT6 |
| Enrichment Score (ES) | -0.6469749 |
| Normalized Enrichment Score (NES) | -1.6899415 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0807225 |
| FWER p-Value | 0.348 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CORO7 | NA | CORO7 Entrez, Source | coronin 7 | 832 | 2.447 | -0.0031 | No |
| 2 | GIT2 | NA | GIT2 Entrez, Source | G protein-coupled receptor kinase interactor 2 | 2662 | 1.439 | -0.0541 | No |
| 3 | ACTR3 | NA | ACTR3 Entrez, Source | ARP3 actin-related protein 3 homolog (yeast) | 2933 | 1.337 | -0.0491 | No |
| 4 | EMP3 | NA | EMP3 Entrez, Source | epithelial membrane protein 3 | 4602 | 0.842 | -0.1009 | No |
| 5 | C17orf62 | NA | C17ORF62 Entrez, Source | chromosome 17 open reading frame 62 | 5267 | 0.672 | -0.1177 | No |
| 6 | INPP5D | NA | INPP5D Entrez, Source | inositol polyphosphate-5-phosphatase, 145kDa | 5714 | 0.576 | -0.1276 | No |
| 7 | ARPC2 | NA | ARPC2 Entrez, Source | actin related protein 2/3 complex, subunit 2, 34kDa | 6220 | 0.494 | -0.1406 | No |
| 8 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 6491 | 0.454 | -0.1454 | No |
| 9 | ADPGK | NA | ADPGK Entrez, Source | ADP-dependent glucokinase | 6741 | 0.424 | -0.1498 | No |
| 10 | BNIP2 | NA | BNIP2 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 2 | 7308 | 0.365 | -0.1665 | No |
| 11 | DAZAP2 | NA | DAZAP2 Entrez, Source | DAZ associated protein 2 | 8574 | 0.258 | -0.2100 | No |
| 12 | ARPC3 | NA | ARPC3 Entrez, Source | actin related protein 2/3 complex, subunit 3, 21kDa | 8966 | 0.232 | -0.2218 | No |
| 13 | CORO1A | NA | CORO1A Entrez, Source | coronin, actin binding protein, 1A | 9074 | 0.226 | -0.2232 | No |
| 14 | TYK2 | NA | TYK2 Entrez, Source | tyrosine kinase 2 | 9609 | 0.197 | -0.2406 | No |
| 15 | CMTM6 | NA | CMTM6 Entrez, Source | CKLF-like MARVEL transmembrane domain containing 6 | 10920 | 0.136 | -0.2871 | No |
| 16 | PAK2 | NA | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 11208 | 0.122 | -0.2963 | No |
| 17 | MSN | NA | MSN Entrez, Source | moesin | 11240 | 0.121 | -0.2961 | No |
| 18 | LCP1 | NA | LCP1 Entrez, Source | lymphocyte cytosolic protein 1 (L-plastin) | 11683 | 0.103 | -0.3111 | No |
| 19 | WAS | NA | WAS Entrez, Source | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 13022 | 0.052 | -0.3596 | No |
| 20 | SEC11A | NA | 13108 | 0.049 | -0.3622 | No | ||
| 21 | ARF6 | NA | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 13142 | 0.047 | -0.3629 | No |
| 22 | LAT2 | NA | LAT2 Entrez, Source | linker for activation of T cells family, member 2 | 13288 | 0.042 | -0.3678 | No |
| 23 | CD48 | NA | CD48 Entrez, Source | CD48 molecule | 13342 | 0.040 | -0.3693 | No |
| 24 | JUNB | NA | JUNB Entrez, Source | jun B proto-oncogene | 13778 | 0.023 | -0.3850 | No |
| 25 | ACAP2 | NA | 13909 | 0.018 | -0.3895 | No | ||
| 26 | DOCK2 | NA | DOCK2 Entrez, Source | dedicator of cytokinesis 2 | 13996 | 0.015 | -0.3925 | No |
| 27 | ZCCHC6 | NA | ZCCHC6 Entrez, Source | zinc finger, CCHC domain containing 6 | 14810 | -0.013 | -0.4222 | No |
| 28 | GPSM3 | NA | GPSM3 Entrez, Source | G-protein signalling modulator 3 (AGS3-like, C. elegans) | 15135 | -0.027 | -0.4338 | No |
| 29 | PTPN6 | NA | PTPN6 Entrez, Source | protein tyrosine phosphatase, non-receptor type 6 | 16067 | -0.063 | -0.4672 | No |
| 30 | CD53 | NA | CD53 Entrez, Source | CD53 molecule | 16512 | -0.081 | -0.4826 | No |
| 31 | LRRFIP1 | NA | LRRFIP1 Entrez, Source | leucine rich repeat (in FLII) interacting protein 1 | 17386 | -0.119 | -0.5133 | No |
| 32 | CYBA | NA | CYBA Entrez, Source | cytochrome b-245, alpha polypeptide | 17388 | -0.119 | -0.5120 | No |
| 33 | TRIM38 | NA | TRIM38 Entrez, Source | tripartite motif-containing 38 | 17856 | -0.145 | -0.5276 | No |
| 34 | ACTR2 | NA | ACTR2 Entrez, Source | ARP2 actin-related protein 2 homolog (yeast) | 18307 | -0.173 | -0.5421 | No |
| 35 | LAPTM5 | NA | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 18352 | -0.175 | -0.5418 | No |
| 36 | HCLS1 | NA | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 18598 | -0.193 | -0.5486 | No |
| 37 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 19761 | -0.296 | -0.5879 | No |
| 38 | SNAP23 | NA | SNAP23 Entrez, Source | synaptosomal-associated protein, 23kDa | 19869 | -0.307 | -0.5884 | No |
| 39 | CAP1 | NA | CAP1 Entrez, Source | CAP, adenylate cyclase-associated protein 1 (yeast) | 20201 | -0.341 | -0.5968 | No |
| 40 | ARPC5 | NA | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 20291 | -0.354 | -0.5961 | No |
| 41 | MBD2 | NA | MBD2 Entrez, Source | methyl-CpG binding domain protein 2 | 20839 | -0.428 | -0.6113 | No |
| 42 | CAPZA1 | NA | CAPZA1 Entrez, Source | capping protein (actin filament) muscle Z-line, alpha 1 | 21240 | -0.487 | -0.6206 | No |
| 43 | SELL | NA | SELL Entrez, Source | selectin L (lymphocyte adhesion molecule 1) | 21687 | -0.568 | -0.6306 | No |
| 44 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 22044 | -0.636 | -0.6365 | No |
| 45 | IQGAP1 | NA | IQGAP1 Entrez, Source | IQ motif containing GTPase activating protein 1 | 22330 | -0.693 | -0.6392 | Yes |
| 46 | CLIC1 | NA | CLIC1 Entrez, Source | chloride intracellular channel 1 | 22393 | -0.706 | -0.6336 | Yes |
| 47 | GRK6 | NA | GRK6 Entrez, Source | G protein-coupled receptor kinase 6 | 22437 | -0.715 | -0.6272 | Yes |
| 48 | SERP1 | NA | SERP1 Entrez, Source | - | 22652 | -0.765 | -0.6264 | Yes |
| 49 | LSP1 | NA | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 22875 | -0.812 | -0.6255 | Yes |
| 50 | USP3 | NA | USP3 Entrez, Source | ubiquitin specific peptidase 3 | 23247 | -0.891 | -0.6291 | Yes |
| 51 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 23560 | -0.968 | -0.6297 | Yes |
| 52 | GMIP | NA | GMIP Entrez, Source | GEM interacting protein | 23688 | -1.003 | -0.6232 | Yes |
| 53 | TAPBP | NA | TAPBP Entrez, Source | TAP binding protein (tapasin) | 23932 | -1.073 | -0.6201 | Yes |
| 54 | RIN3 | NA | RIN3 Entrez, Source | Ras and Rab interactor 3 | 23971 | -1.081 | -0.6094 | Yes |
| 55 | ARHGDIB | NA | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 24415 | -1.214 | -0.6120 | Yes |
| 56 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 24433 | -1.222 | -0.5990 | Yes |
| 57 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 24608 | -1.278 | -0.5911 | Yes |
| 58 | PRR13 | NA | PRR13 Entrez, Source | proline rich 13 | 24628 | -1.284 | -0.5774 | Yes |
| 59 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 25321 | -1.557 | -0.5853 | Yes |
| 60 | ARPC1B | NA | ARPC1B Entrez, Source | actin related protein 2/3 complex, subunit 1B, 41kDa | 25503 | -1.643 | -0.5736 | Yes |
| 61 | ANXA11 | NA | ANXA11 Entrez, Source | annexin A11 | 26366 | -2.184 | -0.5807 | Yes |
| 62 | RNASET2 | NA | RNASET2 Entrez, Source | ribonuclease T2 | 26581 | -2.368 | -0.5621 | Yes |
| 63 | PSMB8 | NA | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 26617 | -2.405 | -0.5364 | Yes |
| 64 | PSMB10 | NA | PSMB10 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 10 | 26623 | -2.409 | -0.5096 | Yes |
| 65 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 26647 | -2.442 | -0.4831 | Yes |
| 66 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 26685 | -2.482 | -0.4567 | Yes |
| 67 | TCIRG1 | NA | TCIRG1 Entrez, Source | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 26835 | -2.712 | -0.4318 | Yes |
| 68 | ELF4 | NA | ELF4 Entrez, Source | E74-like factor 4 (ets domain transcription factor) | 26906 | -2.819 | -0.4028 | Yes |
| 69 | VAV1 | NA | VAV1 Entrez, Source | vav 1 oncogene | 27019 | -3.087 | -0.3724 | Yes |
| 70 | LYN | NA | LYN Entrez, Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 27040 | -3.155 | -0.3378 | Yes |
| 71 | EVI2B | NA | EVI2B Entrez, Source | ecotropic viral integration site 2B | 27063 | -3.219 | -0.3025 | Yes |
| 72 | FMNL1 | NA | FMNL1 Entrez, Source | formin-like 1 | 27118 | -3.438 | -0.2660 | Yes |
| 73 | FXYD5 | NA | FXYD5 Entrez, Source | FXYD domain containing ion transport regulator 5 | 27160 | -3.575 | -0.2275 | Yes |
| 74 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 27181 | -3.688 | -0.1869 | Yes |
| 75 | CASP4 | NA | CASP4 Entrez, Source | caspase 4, apoptosis-related cysteine peptidase | 27208 | -3.856 | -0.1447 | Yes |
| 76 | OSTF1 | NA | OSTF1 Entrez, Source | osteoclast stimulating factor 1 | 27276 | -4.343 | -0.0985 | Yes |
| 77 | ICAM3 | NA | ICAM3 Entrez, Source | intercellular adhesion molecule 3 | 27285 | -4.456 | -0.0489 | Yes |
| 78 | STAT6 | NA | STAT6 Entrez, Source | signal transducer and activator of transcription 6, interleukin-4 induced | 27292 | -4.512 | 0.0014 | Yes |
