Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | MODULE_484 |
| Enrichment Score (ES) | -0.56414604 |
| Normalized Enrichment Score (NES) | -1.6338806 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.10841877 |
| FWER p-Value | 0.505 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SURF1 | NA | SURF1 Entrez, Source | surfeit 1 | 2084 | 1.684 | -0.0335 | No |
| 2 | HP1BP3 | NA | HP1BP3 Entrez, Source | heterochromatin protein 1, binding protein 3 | 2546 | 1.484 | -0.0126 | No |
| 3 | LIMD2 | NA | LIMD2 Entrez, Source | LIM domain containing 2 | 4411 | 0.881 | -0.0585 | No |
| 4 | SNX17 | NA | SNX17 Entrez, Source | sorting nexin 17 | 5462 | 0.626 | -0.0810 | No |
| 5 | NUMA1 | NA | NUMA1 Entrez, Source | nuclear mitotic apparatus protein 1 | 5645 | 0.589 | -0.0727 | No |
| 6 | INPP5D | NA | INPP5D Entrez, Source | inositol polyphosphate-5-phosphatase, 145kDa | 5714 | 0.576 | -0.0605 | No |
| 7 | GMEB2 | NA | GMEB2 Entrez, Source | glucocorticoid modulatory element binding protein 2 | 5869 | 0.551 | -0.0521 | No |
| 8 | CYFIP2 | NA | CYFIP2 Entrez, Source | cytoplasmic FMR1 interacting protein 2 | 6025 | 0.522 | -0.0445 | No |
| 9 | ABTB1 | NA | ABTB1 Entrez, Source | ankyrin repeat and BTB (POZ) domain containing 1 | 6910 | 0.406 | -0.0666 | No |
| 10 | DECR1 | NA | DECR1 Entrez, Source | 2,4-dienoyl CoA reductase 1, mitochondrial | 7703 | 0.325 | -0.0873 | No |
| 11 | CORO1A | NA | CORO1A Entrez, Source | coronin, actin binding protein, 1A | 9074 | 0.226 | -0.1318 | No |
| 12 | TYK2 | NA | TYK2 Entrez, Source | tyrosine kinase 2 | 9609 | 0.197 | -0.1463 | No |
| 13 | UCP1 | NA | UCP1 Entrez, Source | uncoupling protein 1 (mitochondrial, proton carrier) | 9987 | 0.179 | -0.1556 | No |
| 14 | SPPL2B | NA | SPPL2B Entrez, Source | - | 10005 | 0.178 | -0.1516 | No |
| 15 | FAM32A | NA | FAM32A Entrez, Source | family with sequence similarity 32, member A | 11049 | 0.130 | -0.1866 | No |
| 16 | TAZ | NA | TAZ Entrez, Source | tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) | 12468 | 0.072 | -0.2367 | No |
| 17 | RAB4B | NA | RAB4B Entrez, Source | RAB4B, member RAS oncogene family | 13486 | 0.034 | -0.2731 | No |
| 18 | DOCK2 | NA | DOCK2 Entrez, Source | dedicator of cytokinesis 2 | 13996 | 0.015 | -0.2913 | No |
| 19 | SYK | NA | SYK Entrez, Source | spleen tyrosine kinase | 14082 | 0.012 | -0.2942 | No |
| 20 | HDAC7 | NA | 19453 | -0.265 | -0.4842 | No | ||
| 21 | RPS9 | NA | RPS9 Entrez, Source | ribosomal protein S9 | 20591 | -0.391 | -0.5159 | No |
| 22 | RPLP2 | NA | RPLP2 Entrez, Source | ribosomal protein, large, P2 | 21909 | -0.610 | -0.5486 | Yes |
| 23 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 22044 | -0.636 | -0.5373 | Yes |
| 24 | PKN1 | NA | PKN1 Entrez, Source | protein kinase N1 | 22360 | -0.698 | -0.5311 | Yes |
| 25 | LSP1 | NA | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 22875 | -0.812 | -0.5292 | Yes |
| 26 | ADRBK1 | NA | ADRBK1 Entrez, Source | adrenergic, beta, receptor kinase 1 | 23575 | -0.972 | -0.5301 | Yes |
| 27 | SOCS7 | NA | SOCS7 Entrez, Source | suppressor of cytokine signaling 7 | 23727 | -1.013 | -0.5098 | Yes |
| 28 | SYVN1 | NA | SYVN1 Entrez, Source | synovial apoptosis inhibitor 1, synoviolin | 24168 | -1.140 | -0.4969 | Yes |
| 29 | ARHGDIB | NA | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 24415 | -1.214 | -0.4750 | Yes |
| 30 | LDHB | NA | LDHB Entrez, Source | lactate dehydrogenase B | 24731 | -1.320 | -0.4530 | Yes |
| 31 | RPL27 | NA | RPL27 Entrez, Source | ribosomal protein L27 | 25215 | -1.507 | -0.4323 | Yes |
| 32 | TRAP1 | NA | TRAP1 Entrez, Source | TNF receptor-associated protein 1 | 25546 | -1.662 | -0.4021 | Yes |
| 33 | ARHGEF1 | NA | ARHGEF1 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 1 | 25591 | -1.684 | -0.3608 | Yes |
| 34 | CCND3 | NA | CCND3 Entrez, Source | cyclin D3 | 25911 | -1.862 | -0.3251 | Yes |
| 35 | NME3 | NA | NME3 Entrez, Source | non-metastatic cells 3, protein expressed in | 25984 | -1.906 | -0.2792 | Yes |
| 36 | SIPA1 | NA | SIPA1 Entrez, Source | signal-induced proliferation-associated gene 1 | 26147 | -2.020 | -0.2337 | Yes |
| 37 | NBEAL2 | NA | NBEAL2 Entrez, Source | neurobeachin-like 2 | 26497 | -2.299 | -0.1880 | Yes |
| 38 | MAP4K2 | NA | MAP4K2 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 2 | 26664 | -2.459 | -0.1315 | Yes |
| 39 | RPL37 | NA | RPL37 Entrez, Source | ribosomal protein L37 | 26892 | -2.801 | -0.0685 | Yes |
| 40 | ISG20 | NA | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 27089 | -3.317 | 0.0088 | Yes |
