Details for gene set BMI1_DN_MEL18_DN.V1

Table: GSEA Results Summary

Dataset	expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos
Phenotype	mainSample.cls#wt_versus_radiation_repos
Upregulated in class	1
GeneSet	BMI1_DN_MEL18_DN.V1_DN
Enrichment Score (ES)	0.53882086
Normalized Enrichment Score (NES)	1.6225693
Nominal p-value	0.0
FDR q-value	0.0109116165
FWER p-Value	0.077

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FOS	NA	FOS Entrez, Source	v-fos FBJ murine osteosarcoma viral oncogene homolog	3	4.177	0.0221	Yes
2	COL9A3	NA	COL9A3 Entrez, Source	collagen, type IX, alpha 3	38	3.730	0.0406	Yes
3	C1orf54	NA	C1ORF54 Entrez, Source	chromosome 1 open reading frame 54	85	3.528	0.0577	Yes
4	FCGRT	NA	FCGRT Entrez, Source	Fc fragment of IgG, receptor, transporter, alpha	131	3.400	0.0740	Yes
5	PPARGC1A	NA	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	136	3.387	0.0919	Yes
6	PDE4B	NA	PDE4B Entrez, Source	phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)	147	3.365	0.1094	Yes
7	DOK5	NA	DOK5 Entrez, Source	docking protein 5	153	3.346	0.1270	Yes
8	ID4	NA	ID4 Entrez, Source	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	172	3.304	0.1438	Yes
9	CYTL1	NA	CYTL1 Entrez, Source	cytokine-like 1	179	3.299	0.1611	Yes
10	SSPN	NA	SSPN Entrez, Source	sarcospan (Kras oncogene-associated gene)	180	3.298	0.1786	Yes
11	PNMAL1	NA			200	3.272	0.1953	Yes
12	SLC4A4	NA	SLC4A4 Entrez, Source	solute carrier family 4, sodium bicarbonate cotransporter, member 4	223	3.234	0.2117	Yes
13	ITGA7	NA	ITGA7 Entrez, Source	integrin, alpha 7	307	3.066	0.2249	Yes
14	VAV3	NA	VAV3 Entrez, Source	vav 3 oncogene	319	3.047	0.2407	Yes
15	SOX2	NA	SOX2 Entrez, Source	SRY (sex determining region Y)-box 2	342	3.009	0.2558	Yes
16	PDE7B	NA	PDE7B Entrez, Source	phosphodiesterase 7B	411	2.910	0.2688	Yes
17	CLIP3	NA			421	2.902	0.2839	Yes
18	METTL7A	NA	METTL7A Entrez, Source	methyltransferase like 7A	433	2.889	0.2988	Yes
19	REEP2	NA	REEP2 Entrez, Source	receptor accessory protein 2	455	2.863	0.3132	Yes
20	EPHA4	NA	EPHA4 Entrez, Source	EPH receptor A4	459	2.861	0.3283	Yes
21	SEPP1	NA	SEPP1 Entrez, Source	selenoprotein P, plasma, 1	479	2.830	0.3426	Yes
22	ID2	NA	ID2 Entrez, Source	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	481	2.829	0.3576	Yes
23	EYA4	NA	EYA4 Entrez, Source	eyes absent homolog 4 (Drosophila)	612	2.664	0.3670	Yes
24	GAS2	NA	GAS2 Entrez, Source	growth arrest-specific 2	810	2.465	0.3728	Yes
25	UNC5C	NA	UNC5C Entrez, Source	unc-5 homolog C (C. elegans)	878	2.408	0.3831	Yes
26	PEG3	NA	PEG3 Entrez, Source	paternally expressed 3	886	2.400	0.3956	Yes
27	PDLIM5	NA	PDLIM5 Entrez, Source	PDZ and LIM domain 5	1063	2.270	0.4012	Yes
28	OGDHL	NA	OGDHL Entrez, Source	oxoglutarate dehydrogenase-like	1296	2.103	0.4038	Yes
29	CHL1	NA	CHL1 Entrez, Source	cell adhesion molecule with homology to L1CAM (close homolog of L1)	1309	2.095	0.4145	Yes
30	TMOD1	NA	TMOD1 Entrez, Source	tropomodulin 1	1335	2.081	0.4246	Yes
31	SLC16A4	NA	SLC16A4 Entrez, Source	solute carrier family 16, member 4 (monocarboxylic acid transporter 5)	1412	2.026	0.4326	Yes
32	BST2	NA	BST2 Entrez, Source	bone marrow stromal cell antigen 2	1430	2.017	0.4427	Yes
33	KCNJ16	NA	KCNJ16 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 16	1471	1.995	0.4518	Yes
34	WFDC2	NA	WFDC2 Entrez, Source	WAP four-disulfide core domain 2	1637	1.902	0.4558	Yes
35	CA2	NA	CA2 Entrez, Source	carbonic anhydrase II	1735	1.854	0.4621	Yes
36	PROM1	NA	PROM1 Entrez, Source	prominin 1	1895	1.778	0.4657	Yes
37	APOE	NA	APOE Entrez, Source	apolipoprotein E	1901	1.776	0.4749	Yes
38	EVI5	NA	EVI5 Entrez, Source	ecotropic viral integration site 5	2106	1.675	0.4763	Yes
39	FLJ13197	NA	FLJ13197 Entrez, Source	-	2136	1.662	0.4841	Yes
40	AK1	NA	AK1 Entrez, Source	adenylate kinase 1	2256	1.615	0.4883	Yes
41	EFHD1	NA	EFHD1 Entrez, Source	EF-hand domain family, member D1	2376	1.561	0.4922	Yes
42	TMEM176B	NA	TMEM176B Entrez, Source	transmembrane protein 176B	2498	1.506	0.4957	Yes
43	LEPR	NA	LEPR Entrez, Source	leptin receptor	2538	1.487	0.5022	Yes
44	SEC31B	NA	SEC31B Entrez, Source	SEC31 homolog B (S. cerevisiae)	2805	1.385	0.4997	Yes
45	SPAG16	NA	SPAG16 Entrez, Source	sperm associated antigen 16	2830	1.375	0.5062	Yes
46	HIST2H2BE	NA	HIST2H2BE Entrez, Source	histone cluster 2, H2be	2976	1.318	0.5078	Yes
47	CREM	NA	CREM Entrez, Source	cAMP responsive element modulator	3043	1.296	0.5123	Yes
48	PCDH8	NA	PCDH8 Entrez, Source	protocadherin 8	3119	1.269	0.5163	Yes
49	GPX3	NA	GPX3 Entrez, Source	glutathione peroxidase 3 (plasma)	3278	1.220	0.5169	Yes
50	DYNLT3	NA	DYNLT3 Entrez, Source	dynein, light chain, Tctex-type 3	3297	1.215	0.5227	Yes
51	DIRAS3	NA	DIRAS3 Entrez, Source	DIRAS family, GTP-binding RAS-like 3	3323	1.208	0.5282	Yes
52	ZNF423	NA	ZNF423 Entrez, Source	zinc finger protein 423	3454	1.167	0.5296	Yes
53	GAS7	NA	GAS7 Entrez, Source	growth arrest-specific 7	3520	1.148	0.5333	Yes
54	NR2E1	NA	NR2E1 Entrez, Source	nuclear receptor subfamily 2, group E, member 1	3718	1.076	0.5318	Yes
55	TRIM2	NA	TRIM2 Entrez, Source	tripartite motif-containing 2	3879	1.024	0.5313	Yes
56	NMNAT2	NA	NMNAT2 Entrez, Source	nicotinamide nucleotide adenylyltransferase 2	3931	1.008	0.5348	Yes
57	ETFB	NA	ETFB Entrez, Source	electron-transfer-flavoprotein, beta polypeptide	4202	0.931	0.5298	Yes
58	IFITM1	NA	IFITM1 Entrez, Source	interferon induced transmembrane protein 1 (9-27)	4366	0.891	0.5286	Yes
59	TMEM176A	NA	TMEM176A Entrez, Source	transmembrane protein 176A	4393	0.884	0.5323	Yes
60	SEMA3E	NA	SEMA3E Entrez, Source	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	4517	0.857	0.5323	Yes
61	PCP4	NA	PCP4 Entrez, Source	Purkinje cell protein 4	4601	0.842	0.5337	Yes
62	NUDT9	NA	NUDT9 Entrez, Source	nudix (nucleoside diphosphate linked moiety X)-type motif 9	4838	0.779	0.5292	Yes
63	IDH1	NA	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	4940	0.757	0.5295	Yes
64	SERPINI1	NA	SERPINI1 Entrez, Source	serpin peptidase inhibitor, clade I (neuroserpin), member 1	4947	0.755	0.5333	Yes
65	CXCL14	NA	CXCL14 Entrez, Source	chemokine (C-X-C motif) ligand 14	4987	0.746	0.5358	Yes
66	TCEA2	NA	TCEA2 Entrez, Source	transcription elongation factor A (SII), 2	5013	0.740	0.5388	Yes
67	CTSH	NA	CTSH Entrez, Source	cathepsin H	5119	0.715	0.5388	No
68	KIAA1310	NA			5950	0.537	0.5111	No
69	S100A4	NA	S100A4 Entrez, Source	S100 calcium binding protein A4	6035	0.521	0.5107	No
70	SECTM1	NA	SECTM1 Entrez, Source	secreted and transmembrane 1	6078	0.515	0.5119	No
71	A2M	NA	A2M Entrez, Source	alpha-2-macroglobulin	6145	0.506	0.5122	No
72	ARSD	NA	ARSD Entrez, Source	arylsulfatase D	6195	0.497	0.5130	No
73	MSRB2	NA	MSRB2 Entrez, Source	methionine sulfoxide reductase B2	6203	0.497	0.5154	No
74	DPYD	NA	DPYD Entrez, Source	dihydropyrimidine dehydrogenase	6599	0.441	0.5032	No
75	KCNV1	NA	KCNV1 Entrez, Source	potassium channel, subfamily V, member 1	6890	0.409	0.4947	No
76	NSF	NA	NSF Entrez, Source	N-ethylmaleimide-sensitive factor	6960	0.401	0.4943	No
77	GPR88	NA	GPR88 Entrez, Source	G protein-coupled receptor 88	7382	0.357	0.4807	No
78	PRDX2	NA	PRDX2 Entrez, Source	peroxiredoxin 2	7779	0.320	0.4679	No
79	DPM3	NA	DPM3 Entrez, Source	dolichyl-phosphate mannosyltransferase polypeptide 3	7834	0.315	0.4675	No
80	GNPTAB	NA	GNPTAB Entrez, Source	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	8077	0.294	0.4602	No
81	RBP4	NA	RBP4 Entrez, Source	retinol binding protein 4, plasma	8284	0.278	0.4541	No
82	EDN3	NA	EDN3 Entrez, Source	endothelin 3	8684	0.250	0.4407	No
83	TCEAL2	NA	TCEAL2 Entrez, Source	transcription elongation factor A (SII)-like 2	8803	0.241	0.4377	No
84	MXRA5	NA	MXRA5 Entrez, Source	matrix-remodelling associated 5	8842	0.239	0.4376	No
85	ESRP1	NA			8900	0.236	0.4367	No
86	MAOB	NA	MAOB Entrez, Source	monoamine oxidase B	9285	0.215	0.4237	No
87	CDH10	NA	CDH10 Entrez, Source	cadherin 10, type 2 (T2-cadherin)	10163	0.172	0.3924	No
88	SLPI	NA	SLPI Entrez, Source	secretory leukocyte peptidase inhibitor	10226	0.168	0.3910	No
89	PDE3A	NA	PDE3A Entrez, Source	phosphodiesterase 3A, cGMP-inhibited	10425	0.159	0.3845	No
90	DLK1	NA	DLK1 Entrez, Source	delta-like 1 homolog (Drosophila)	11014	0.132	0.3636	No
91	PIGN	NA	PIGN Entrez, Source	phosphatidylinositol glycan anchor biosynthesis, class N	11217	0.122	0.3568	No
92	EPYC	NA			11294	0.118	0.3547	No
93	ACOX2	NA	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	11947	0.092	0.3312	No
94	ERCC4	NA	ERCC4 Entrez, Source	excision repair cross-complementing rodent repair deficiency, complementation group 4	12069	0.088	0.3272	No
95	AQP3	NA	AQP3 Entrez, Source	aquaporin 3 (Gill blood group)	12539	0.070	0.3103	No
96	SMR3B	NA	SMR3B Entrez, Source	submaxillary gland androgen regulated protein 3 homolog B (mouse)	12625	0.066	0.3075	No
97	NEFH	NA	NEFH Entrez, Source	neurofilament, heavy polypeptide 200kDa	12921	0.056	0.2970	No
98	SPINT1	NA	SPINT1 Entrez, Source	serine peptidase inhibitor, Kunitz type 1	12941	0.055	0.2966	No
99	SCNN1A	NA	SCNN1A Entrez, Source	sodium channel, nonvoltage-gated 1 alpha	13451	0.035	0.2780	No
100	CUX2	NA			14555	-0.004	0.2375	No
101	CH25H	NA	CH25H Entrez, Source	cholesterol 25-hydroxylase	14556	-0.004	0.2375	No
102	COL14A1	NA	COL14A1 Entrez, Source	collagen, type XIV, alpha 1 (undulin)	14969	-0.020	0.2224	No
103	GTF2A1L	NA			15724	-0.049	0.1950	No
104	LECT1	NA	LECT1 Entrez, Source	leukocyte cell derived chemotaxin 1	15777	-0.051	0.1933	No
105	SLC17A6	NA	SLC17A6 Entrez, Source	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	15850	-0.054	0.1910	No
106	LMO3	NA	LMO3 Entrez, Source	LIM domain only 3 (rhombotin-like 2)	16466	-0.080	0.1688	No
107	CCKAR	NA	CCKAR Entrez, Source	cholecystokinin A receptor	16682	-0.088	0.1613	No
108	PCSK1	NA	PCSK1 Entrez, Source	proprotein convertase subtilisin/kexin type 1	16703	-0.089	0.1611	No
109	STON1	NA	STON1 Entrez, Source	stonin 1	16900	-0.097	0.1544	No
110	PDCD4	NA	PDCD4 Entrez, Source	programmed cell death 4 (neoplastic transformation inhibitor)	17060	-0.104	0.1491	No
111	IFI27	NA	IFI27 Entrez, Source	interferon, alpha-inducible protein 27	17553	-0.127	0.1316	No
112	OLFM4	NA	OLFM4 Entrez, Source	olfactomedin 4	17764	-0.138	0.1247	No
113	C6orf64	NA	C6ORF64 Entrez, Source	chromosome 6 open reading frame 64	17783	-0.139	0.1247	No
114	PENK	NA	PENK Entrez, Source	proenkephalin	17908	-0.148	0.1210	No
115	GPR137B	NA	GPR137B Entrez, Source	G protein-coupled receptor 137B	19045	-0.231	0.0804	No
116	IRF9	NA			19523	-0.272	0.0643	No
117	ABCA4	NA	ABCA4 Entrez, Source	ATP-binding cassette, sub-family A (ABC1), member 4	19843	-0.304	0.0542	No
118	TSFM	NA	TSFM Entrez, Source	Ts translation elongation factor, mitochondrial	19929	-0.313	0.0527	No
119	HOXC13	NA	HOXC13 Entrez, Source	homeobox C13	20171	-0.339	0.0456	No
120	KLHL2	NA	KLHL2 Entrez, Source	kelch-like 2, Mayven (Drosophila)	20265	-0.350	0.0441	No
121	MIA	NA	MIA Entrez, Source	melanoma inhibitory activity	20282	-0.352	0.0454	No
122	TTC33	NA	TTC33 Entrez, Source	tetratricopeptide repeat domain 33	20419	-0.370	0.0423	No
123	EHHADH	NA	EHHADH Entrez, Source	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	20792	-0.421	0.0309	No
124	C16orf80	NA	C16ORF80 Entrez, Source	chromosome 16 open reading frame 80	20949	-0.445	0.0275	No
125	NEAT1	NA			21149	-0.474	0.0227	No
126	MTA2	NA	MTA2 Entrez, Source	metastasis associated 1 family, member 2	21849	-0.599	0.0002	No
127	API5	NA	API5 Entrez, Source	apoptosis inhibitor 5	22332	-0.694	-0.0139	No
128	TSPAN1	NA	TSPAN1 Entrez, Source	tetraspanin 1	23502	-0.951	-0.0518	No
129	BMI1	NA	BMI1 Entrez, Source	B lymphoma Mo-MLV insertion region (mouse)	23952	-1.077	-0.0626	No
130	UBE2L6	NA	UBE2L6 Entrez, Source	ubiquitin-conjugating enzyme E2L 6	24851	-1.360	-0.0885	No
131	DDX60	NA			24864	-1.366	-0.0816	No
132	DUSP2	NA	DUSP2 Entrez, Source	dual specificity phosphatase 2	24949	-1.396	-0.0773	No
133	C9orf46	NA	C9ORF46 Entrez, Source	chromosome 9 open reading frame 46	25030	-1.431	-0.0727	No
134	MCTS1	NA	MCTS1 Entrez, Source	malignant T cell amplified sequence 1	25232	-1.514	-0.0720	No
135	RNF115	NA			25236	-1.517	-0.0641	No
136	SPINT2	NA	SPINT2 Entrez, Source	serine peptidase inhibitor, Kunitz type, 2	25309	-1.552	-0.0585	No
137	PEX11A	NA	PEX11A Entrez, Source	peroxisomal biogenesis factor 11A	25429	-1.608	-0.0543	No
138	IFI6	NA	IFI6 Entrez, Source	interferon, alpha-inducible protein 6	25912	-1.862	-0.0622	No
139	CRLF1	NA	CRLF1 Entrez, Source	cytokine receptor-like factor 1	26139	-2.008	-0.0598	No
140	PDE5A	NA	PDE5A Entrez, Source	phosphodiesterase 5A, cGMP-specific	26369	-2.191	-0.0566	No
141	ASPHD1	NA	ASPHD1 Entrez, Source	aspartate beta-hydroxylase domain containing 1	26501	-2.302	-0.0492	No
142	OSBPL10	NA	OSBPL10 Entrez, Source	oxysterol binding protein-like 10	26811	-2.666	-0.0464	No
143	SOCS2	NA	SOCS2 Entrez, Source	suppressor of cytokine signaling 2	26833	-2.703	-0.0328	No
144	MAP7	NA	MAP7 Entrez, Source	microtubule-associated protein 7	26837	-2.718	-0.0185	No
145	IL1R1	NA	IL1R1 Entrez, Source	interleukin 1 receptor, type I	26964	-2.933	-0.0076	No
146	LY6E	NA	LY6E Entrez, Source	lymphocyte antigen 6 complex, locus E	27224	-3.952	0.0039	No