Datasetexpression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls
#wt_versus_radiation.mainSample.cls
#wt_versus_radiation_repos
PhenotypemainSample.cls#wt_versus_radiation_repos
Upregulated in class1
GeneSetBRCA1_DN.V1_UP
Enrichment Score (ES)0.46068618
Normalized Enrichment Score (NES)1.8761055
Nominal p-value0.0
FDR q-value0.0024836194
FWER p-Value0.003
Table: GSEA Results Summary



Fig 1: Enrichment plot: BRCA1_DN.V1_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MAP2NAMAP2
Entrez,  Source
microtubule-associated protein 2543.6430.0330Yes
2RNF122NARNF122
Entrez,  Source
ring finger protein 1222133.2470.0583Yes
3TNCNATNC
Entrez,  Source
tenascin C (hexabrachion)2583.1600.0870Yes
4ZNF529NAZNF529
Entrez,  Source
zinc finger protein 5294362.8880.1082Yes
5KCNA2NAKCNA2
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 25632.7030.1295Yes
6ZNF682NAZNF682
Entrez,  Source
zinc finger protein 6826382.6360.1521Yes
7LEPREL2NALEPREL2
Entrez,  Source
leprecan-like 26912.5870.1750Yes
8CYP2U1NACYP2U1
Entrez,  Source
cytochrome P450, family 2, subfamily U, polypeptide 18312.4470.1934Yes
9CTNNA3NACTNNA3
Entrez,  Source
catenin (cadherin-associated protein), alpha 39822.3260.2102Yes
10LHX6NALHX6
Entrez,  Source
LIM homeobox 610652.2690.2290Yes
11THBS2NATHBS2
Entrez,  Source
thrombospondin 211322.2240.2479Yes
12LDB2NALDB2
Entrez,  Source
LIM domain binding 211342.2230.2692Yes
13TIMP4NATIMP4
Entrez,  Source
TIMP metallopeptidase inhibitor 411662.1980.2891Yes
14GABRB1NAGABRB1
Entrez,  Source
gamma-aminobutyric acid (GABA) A receptor, beta 112742.1190.3055Yes
15SLC16A4NASLC16A4
Entrez,  Source
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)14122.0260.3199Yes
16STARNASTAR
Entrez,  Source
steroidogenic acute regulator14252.0190.3389Yes
17KCNJ16NAKCNJ16
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 1614711.9950.3564Yes
18NKX2-2NANKX2-2
Entrez,  Source
NK2 transcription factor related, locus 2 (Drosophila)15621.9450.3717Yes
19PTPRSNAPTPRS
Entrez,  Source
protein tyrosine phosphatase, receptor type, S17091.8670.3843Yes
20CNTN6NACNTN6
Entrez,  Source
contactin 620891.6820.3865Yes
21CILPNACILP
Entrez,  Source
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase22621.6120.3956Yes
22IPWNAIPW
Entrez,  Source
imprinted in Prader-Willi syndrome25731.4710.3983Yes
23APBB1NAAPBB1
Entrez,  Source
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)26421.4470.4097Yes
24FAM46CNAFAM46C
Entrez,  Source
family with sequence similarity 46, member C28181.3800.4165Yes
25TTLL7NATTLL7
Entrez,  Source
tubulin tyrosine ligase-like family, member 733171.2090.4098Yes
26LRRTM2NALRRTM2
Entrez,  Source
leucine rich repeat transmembrane neuronal 233741.1920.4192Yes
27ZNF423NAZNF423
Entrez,  Source
zinc finger protein 42334541.1670.4275Yes
28FCGR2CNAFCGR2C
Entrez,  Source
Fc fragment of IgG, low affinity IIb, receptor for (CD32)37941.0530.4251Yes
29SIX1NASIX1
Entrez,  Source
sine oculis homeobox homolog 1 (Drosophila)39161.0120.4304Yes
30CG030NACG030
Entrez,  Source
-39890.9890.4373Yes
31SP4NASP4
Entrez,  Source
Sp4 transcription factor41720.9400.4396Yes
32EXTL1NAEXTL1
Entrez,  Source
exostoses (multiple)-like 142600.9180.4452Yes
33TRPM8NATRPM8
Entrez,  Source
transient receptor potential cation channel, subfamily M, member 842640.9170.4539Yes
34B3GALT2NAB3GALT2
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 243160.9040.4607Yes
35NLGN4YNANLGN4Y
Entrez,  Source
neuroligin 4, Y-linked46850.8170.4550No
36GRID2NAGRID2
Entrez,  Source
glutamate receptor, ionotropic, delta 250540.7320.4485No
37CD3DNACD3D
Entrez,  Source
CD3d molecule, delta (CD3-TCR complex)55350.6100.4367No
38NPHS2NANPHS2
Entrez,  Source
nephrosis 2, idiopathic, steroid-resistant (podocin)60790.5150.4217No
39WDR25NAWDR25
Entrez,  Source
WD repeat domain 2563870.4690.4149No
40HIST1H2BJNAHIST1H2BJ
Entrez,  Source
histone cluster 1, H2bj65660.4450.4126No
41GPR6NAGPR6
Entrez,  Source
G protein-coupled receptor 669690.4000.4017No
42LTC4SNALTC4S
Entrez,  Source
leukotriene C4 synthase70620.3910.4020No
43CHATNACHAT
Entrez,  Source
choline acetyltransferase76170.3340.3849No
44TSSK2NATSSK2
Entrez,  Source
testis-specific serine kinase 276190.3340.3880No
45LRMPNALRMP
Entrez,  Source
lymphoid-restricted membrane protein80980.2920.3733No
46ANGPT4NAANGPT4
Entrez,  Source
angiopoietin 482550.2810.3702No
47DAGLANA87560.2440.3542No
48PRSS21NAPRSS21
Entrez,  Source
protease, serine, 21 (testisin)93840.2090.3331No
49CCKBRNACCKBR
Entrez,  Source
cholecystokinin B receptor94210.2070.3338No
50CD160NACD160
Entrez,  Source
CD160 molecule95480.2010.3311No
51LILRP2NALILRP2
Entrez,  Source
leukocyte immunoglobulin-like receptor pseudogene 298520.1860.3217No
52IL1RL2NAIL1RL2
Entrez,  Source
interleukin 1 receptor-like 2102000.1700.3106No
53NEUROD6NANEUROD6
Entrez,  Source
neurogenic differentiation 6104340.1590.3036No
54POU2F3NAPOU2F3
Entrez,  Source
POU domain, class 2, transcription factor 3106590.1490.2968No
55PRAMEF12NAPRAMEF12
Entrez,  Source
PRAME family member 12107970.1410.2931No
56KLHL35NA108650.1390.2919No
57IL17ANAIL17A
Entrez,  Source
interleukin 17A113360.1160.2758No
58CRYGDNACRYGD
Entrez,  Source
crystallin, gamma D113800.1140.2753No
59IFNA14NAIFNA14
Entrez,  Source
interferon, alpha 14114540.1120.2737No
60PRKACGNAPRKACG
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, gamma115210.1100.2723No
61KCNB2NAKCNB2
Entrez,  Source
potassium voltage-gated channel, Shab-related subfamily, member 2117090.1020.2664No
62RAG2NARAG2
Entrez,  Source
recombination activating gene 2118720.0950.2614No
63THPONATHPO
Entrez,  Source
thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)125410.0700.2375No
64TRGV7NATRGV7
Entrez,  Source
T cell receptor gamma variable 7125750.0680.2369No
65LGALS9NALGALS9
Entrez,  Source
lectin, galactoside-binding, soluble, 9 (galectin 9)126020.0670.2366No
66IQCA1NA129010.0570.2262No
67DDX25NADDX25
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25132010.0450.2156No
68HOXB7NAHOXB7
Entrez,  Source
homeobox B7132960.0410.2126No
69USP9YNAUSP9Y
Entrez,  Source
ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)133630.0390.2105No
70CLEC7ANACLEC7A
Entrez,  Source
C-type lectin domain family 7, member A134830.0340.2065No
71INE1NAINE1
Entrez,  Source
inactivation escape 1135140.0330.2057No
72CD34NACD34
Entrez,  Source
CD34 molecule135770.0300.2037No
73SPO11NASPO11
Entrez,  Source
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)137630.0240.1971No
74TRPA1NATRPA1
Entrez,  Source
transient receptor potential cation channel, subfamily A, member 1138310.0210.1949No
75HAAONAHAAO
Entrez,  Source
3-hydroxyanthranilate 3,4-dioxygenase139590.0170.1903No
76CMKLR1NACMKLR1
Entrez,  Source
chemokine-like receptor 1140270.0140.1880No
77ARHGAP15NAARHGAP15
Entrez,  Source
Rho GTPase activating protein 15140930.0120.1857No
78UPK1BNAUPK1B
Entrez,  Source
uroplakin 1B142160.0080.1813No
79CTLA4NACTLA4
Entrez,  Source
cytotoxic T-lymphocyte-associated protein 4144120.0010.1742No
80TACR3NATACR3
Entrez,  Source
tachykinin receptor 314940-0.0190.1550No
81CHRNA6NACHRNA6
Entrez,  Source
cholinergic receptor, nicotinic, alpha 615092-0.0250.1497No
82CDX1NACDX1
Entrez,  Source
caudal type homeobox transcription factor 115259-0.0310.1439No
83IL5NAIL5
Entrez,  Source
interleukin 5 (colony-stimulating factor, eosinophil)15268-0.0320.1439No
84NEUROD4NANEUROD4
Entrez,  Source
neurogenic differentiation 415357-0.0350.1410No
85SLURP1NASLURP1
Entrez,  Source
secreted LY6/PLAUR domain containing 115581-0.0440.1332No
86TP53TG5NA16201-0.0690.1111No
87CLDN6NACLDN6
Entrez,  Source
claudin 616248-0.0710.1101No
88LOC652147NALOC652147
Entrez,  Source
-16438-0.0790.1039No
89C7orf63NA16691-0.0890.0955No
90HIST1H3ENAHIST1H3E
Entrez,  Source
histone cluster 1, H3e16714-0.0900.0955No
91APOHNAAPOH
Entrez,  Source
apolipoprotein H (beta-2-glycoprotein I)16916-0.0980.0891No
92ASMTNAASMT
Entrez,  Source
acetylserotonin O-methyltransferase16925-0.0980.0897No
93LRTM1NALRTM1
Entrez,  Source
leucine-rich repeats and transmembrane domains 117341-0.1170.0756No
94BTG4NABTG4
Entrez,  Source
B-cell translocation gene 417352-0.1170.0764No
95KCNH7NAKCNH7
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 717362-0.1180.0772No
96PHOX2BNAPHOX2B
Entrez,  Source
paired-like homeobox 2b17549-0.1260.0715No
97DAZLNADAZL
Entrez,  Source
deleted in azoospermia-like17701-0.1340.0673No
98CLDN14NACLDN14
Entrez,  Source
claudin 1417779-0.1390.0658No
99CDKL5NACDKL5
Entrez,  Source
cyclin-dependent kinase-like 517788-0.1390.0668No
100GJA5NAGJA5
Entrez,  Source
gap junction protein, alpha 5, 40kDa (connexin 40)18191-0.1650.0536No
101CDH22NACDH22
Entrez,  Source
cadherin-like 2218597-0.1930.0406No
102TRPV6NATRPV6
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 618921-0.2200.0308No
103SLCO1A2NASLCO1A2
Entrez,  Source
solute carrier organic anion transporter family, member 1A219188-0.2430.0234No
104PIPNAPIP
Entrez,  Source
prolactin-induced protein19201-0.2440.0253No
105GMLNAGML
Entrez,  Source
GPI anchored molecule like protein19427-0.2630.0195No
106PAEPNAPAEP
Entrez,  Source
progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein)19460-0.2660.0209No
107MYBPC1NAMYBPC1
Entrez,  Source
myosin binding protein C, slow type19575-0.2780.0194No
108RHOHNARHOH
Entrez,  Source
ras homolog gene family, member H19652-0.2850.0193No
109SGCANASGCA
Entrez,  Source
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)20289-0.354-0.0007No
110TLX3NATLX3
Entrez,  Source
T-cell leukemia homeobox 320332-0.3600.0012No
111RPP25NARPP25
Entrez,  Source
ribonuclease P 25kDa subunit21277-0.493-0.0287No
112ZNF780BNAZNF780B
Entrez,  Source
zinc finger protein 780B21359-0.508-0.0268No
113FCGBPNAFCGBP
Entrez,  Source
Fc fragment of IgG binding protein21504-0.536-0.0270No
114DENND1CNADENND1C
Entrez,  Source
DENN/MADD domain containing 1C22056-0.639-0.0411No
115CHD5NACHD5
Entrez,  Source
chromodomain helicase DNA binding protein 522061-0.640-0.0351No
116RPS2P45NA22235-0.672-0.0350No
117KLK8NAKLK8
Entrez,  Source
kallikrein 8 (neuropsin/ovasin)22369-0.699-0.0332No
118CDH13NACDH13
Entrez,  Source
cadherin 13, H-cadherin (heart)23118-0.862-0.0524No
119ETNK2NAETNK2
Entrez,  Source
ethanolamine kinase 223351-0.914-0.0522No
120RLN1NARLN1
Entrez,  Source
relaxin 123673-0.999-0.0544No
121SHANK1NASHANK1
Entrez,  Source
SH3 and multiple ankyrin repeat domains 124100-1.118-0.0594No
122OSR2NAOSR2
Entrez,  Source
odd-skipped related 2 (Drosophila)24565-1.268-0.0642No
123SLC16A6NASLC16A6
Entrez,  Source
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)24660-1.296-0.0553No
124SLC43A1NASLC43A1
Entrez,  Source
solute carrier family 43, member 124844-1.358-0.0490No
125HMGA2NAHMGA2
Entrez,  Source
high mobility group AT-hook 225163-1.488-0.0464No
126CCL27NACCL27
Entrez,  Source
chemokine (C-C motif) ligand 2725417-1.600-0.0403No
127ISYNA1NAISYNA1
Entrez,  Source
-25481-1.631-0.0270No
128AIM2NAAIM2
Entrez,  Source
absent in melanoma 225899-1.855-0.0245No
129MTMR8NAMTMR8
Entrez,  Source
myotubularin related protein 826665-2.459-0.0290No
130RCN3NARCN3
Entrez,  Source
reticulocalbin 3, EF-hand calcium binding domain26680-2.475-0.0058No
131VAV1NAVAV1
Entrez,  Source
vav 1 oncogene27019-3.0870.0114No
Table: GSEA details [plain text format]



Fig 2: BRCA1_DN.V1_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BRCA1_DN.V1_UP: Random ES distribution   
Gene set null distribution of ES for BRCA1_DN.V1_UP