Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | CRX_DN.V1_DN |
| Enrichment Score (ES) | -0.2841676 |
| Normalized Enrichment Score (NES) | -1.2546443 |
| Nominal p-value | 0.08 |
| FDR q-value | 0.22613646 |
| FWER p-Value | 0.843 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | INHBB | NA | INHBB Entrez, Source | inhibin, beta B (activin AB beta polypeptide) | 5 | 4.070 | 0.0287 | No |
| 2 | COL4A2 | NA | COL4A2 Entrez, Source | collagen, type IV, alpha 2 | 34 | 3.759 | 0.0543 | No |
| 3 | FABP7 | NA | FABP7 Entrez, Source | fatty acid binding protein 7, brain | 323 | 3.044 | 0.0653 | No |
| 4 | GNG11 | NA | GNG11 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 11 | 386 | 2.948 | 0.0839 | No |
| 5 | FRMD6 | NA | FRMD6 Entrez, Source | FERM domain containing 6 | 392 | 2.939 | 0.1046 | No |
| 6 | SEMA5B | NA | SEMA5B Entrez, Source | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 409 | 2.912 | 0.1247 | No |
| 7 | GLIPR2 | NA | 441 | 2.880 | 0.1439 | No | ||
| 8 | JAM3 | NA | JAM3 Entrez, Source | junctional adhesion molecule 3 | 696 | 2.580 | 0.1529 | No |
| 9 | TRPC3 | NA | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 805 | 2.466 | 0.1664 | No |
| 10 | LRRC4 | NA | LRRC4 Entrez, Source | leucine rich repeat containing 4 | 840 | 2.441 | 0.1825 | No |
| 11 | TMOD1 | NA | TMOD1 Entrez, Source | tropomodulin 1 | 1335 | 2.081 | 0.1791 | No |
| 12 | COL16A1 | NA | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 1355 | 2.070 | 0.1930 | No |
| 13 | BCL3 | NA | BCL3 Entrez, Source | B-cell CLL/lymphoma 3 | 1523 | 1.965 | 0.2008 | No |
| 14 | MAP3K8 | NA | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 1718 | 1.864 | 0.2069 | No |
| 15 | PLOD2 | NA | PLOD2 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 1750 | 1.849 | 0.2189 | No |
| 16 | SLC26A4 | NA | SLC26A4 Entrez, Source | solute carrier family 26, member 4 | 1834 | 1.807 | 0.2287 | No |
| 17 | HNF1A | NA | 2042 | 1.702 | 0.2331 | No | ||
| 18 | SH3BP4 | NA | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 2120 | 1.667 | 0.2421 | No |
| 19 | C1QTNF6 | NA | C1QTNF6 Entrez, Source | C1q and tumor necrosis factor related protein 6 | 2493 | 1.508 | 0.2391 | No |
| 20 | CAMK2B | NA | CAMK2B Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | 2960 | 1.324 | 0.2314 | No |
| 21 | CDKN1A | NA | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3168 | 1.250 | 0.2326 | No |
| 22 | ST3GAL3 | NA | ST3GAL3 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | 3237 | 1.230 | 0.2389 | No |
| 23 | TRIM13 | NA | TRIM13 Entrez, Source | tripartite motif-containing 13 | 3301 | 1.214 | 0.2452 | No |
| 24 | BACH2 | NA | BACH2 Entrez, Source | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 3426 | 1.176 | 0.2489 | No |
| 25 | SKAP2 | NA | SKAP2 Entrez, Source | src kinase associated phosphoprotein 2 | 3810 | 1.047 | 0.2423 | No |
| 26 | TLE1 | NA | TLE1 Entrez, Source | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 3929 | 1.009 | 0.2451 | No |
| 27 | FMN1 | NA | FMN1 Entrez, Source | formin 1 | 4156 | 0.942 | 0.2435 | No |
| 28 | TMEM176A | NA | TMEM176A Entrez, Source | transmembrane protein 176A | 4393 | 0.884 | 0.2411 | No |
| 29 | INSM1 | NA | INSM1 Entrez, Source | insulinoma-associated 1 | 4483 | 0.865 | 0.2439 | No |
| 30 | DHX32 | NA | DHX32 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 4545 | 0.851 | 0.2477 | No |
| 31 | TECTA | NA | TECTA Entrez, Source | tectorin alpha | 4568 | 0.847 | 0.2529 | No |
| 32 | TNNC2 | NA | TNNC2 Entrez, Source | troponin C type 2 (fast) | 4681 | 0.818 | 0.2546 | No |
| 33 | NUPR1 | NA | NUPR1 Entrez, Source | - | 4697 | 0.812 | 0.2598 | No |
| 34 | SPSB2 | NA | SPSB2 Entrez, Source | splA/ryanodine receptor domain and SOCS box containing 2 | 4937 | 0.757 | 0.2564 | No |
| 35 | KLF10 | NA | KLF10 Entrez, Source | Kruppel-like factor 10 | 5734 | 0.573 | 0.2312 | No |
| 36 | ACSS1 | NA | ACSS1 Entrez, Source | acyl-CoA synthetase short-chain family member 1 | 5892 | 0.549 | 0.2293 | No |
| 37 | MYOZ1 | NA | MYOZ1 Entrez, Source | myozenin 1 | 5917 | 0.543 | 0.2323 | No |
| 38 | CDH20 | NA | CDH20 Entrez, Source | cadherin 20, type 2 | 6088 | 0.513 | 0.2297 | No |
| 39 | LDB1 | NA | LDB1 Entrez, Source | LIM domain binding 1 | 6304 | 0.481 | 0.2252 | No |
| 40 | FABP5 | NA | FABP5 Entrez, Source | fatty acid binding protein 5 (psoriasis-associated) | 6484 | 0.454 | 0.2218 | No |
| 41 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 6780 | 0.420 | 0.2139 | No |
| 42 | FOXD1 | NA | FOXD1 Entrez, Source | forkhead box D1 | 6812 | 0.416 | 0.2157 | No |
| 43 | MYOCD | NA | MYOCD Entrez, Source | myocardin | 7014 | 0.396 | 0.2112 | No |
| 44 | GLYCAM1 | NA | GLYCAM1 Entrez, Source | glycosylation dependent cell adhesion molecule 1 | 7168 | 0.379 | 0.2082 | No |
| 45 | CSN3 | NA | CSN3 Entrez, Source | casein kappa | 7234 | 0.372 | 0.2085 | No |
| 46 | LIX1 | NA | LIX1 Entrez, Source | Lix1 homolog (mouse) | 7240 | 0.372 | 0.2109 | No |
| 47 | NAB1 | NA | NAB1 Entrez, Source | NGFI-A binding protein 1 (EGR1 binding protein 1) | 7309 | 0.364 | 0.2110 | No |
| 48 | RNASE4 | NA | RNASE4 Entrez, Source | ribonuclease, RNase A family, 4 | 7871 | 0.311 | 0.1926 | No |
| 49 | CHRNB4 | NA | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 8139 | 0.289 | 0.1848 | No |
| 50 | RBP4 | NA | RBP4 Entrez, Source | retinol binding protein 4, plasma | 8284 | 0.278 | 0.1815 | No |
| 51 | KSR1 | NA | KSR1 Entrez, Source | kinase suppressor of ras 1 | 8439 | 0.267 | 0.1777 | No |
| 52 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 8450 | 0.266 | 0.1793 | No |
| 53 | CEBPD | NA | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 8552 | 0.259 | 0.1774 | No |
| 54 | SMPDL3A | NA | SMPDL3A Entrez, Source | sphingomyelin phosphodiesterase, acid-like 3A | 8919 | 0.234 | 0.1656 | No |
| 55 | GHRH | NA | GHRH Entrez, Source | growth hormone releasing hormone | 8998 | 0.230 | 0.1644 | No |
| 56 | CHRNA3 | NA | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 9167 | 0.221 | 0.1597 | No |
| 57 | CCKBR | NA | CCKBR Entrez, Source | cholecystokinin B receptor | 9421 | 0.207 | 0.1519 | No |
| 58 | CXCL13 | NA | CXCL13 Entrez, Source | chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) | 9427 | 0.207 | 0.1532 | No |
| 59 | H6PD | NA | H6PD Entrez, Source | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | 9560 | 0.200 | 0.1498 | No |
| 60 | SLC22A7 | NA | SLC22A7 Entrez, Source | solute carrier family 22 (organic anion transporter), member 7 | 9682 | 0.194 | 0.1467 | No |
| 61 | TCTE3 | NA | TCTE3 Entrez, Source | t-complex-associated-testis-expressed 3 | 9843 | 0.186 | 0.1421 | No |
| 62 | LXN | NA | LXN Entrez, Source | latexin | 9955 | 0.181 | 0.1393 | No |
| 63 | PCOLCE | NA | PCOLCE Entrez, Source | procollagen C-endopeptidase enhancer | 10193 | 0.170 | 0.1318 | No |
| 64 | GDAP1L1 | NA | GDAP1L1 Entrez, Source | ganglioside-induced differentiation-associated protein 1-like 1 | 10462 | 0.158 | 0.1231 | No |
| 65 | SMOC2 | NA | SMOC2 Entrez, Source | SPARC related modular calcium binding 2 | 11458 | 0.112 | 0.0873 | No |
| 66 | C1QC | NA | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 11672 | 0.103 | 0.0802 | No |
| 67 | EYA1 | NA | EYA1 Entrez, Source | eyes absent homolog 1 (Drosophila) | 12135 | 0.085 | 0.0638 | No |
| 68 | TNFRSF13B | NA | TNFRSF13B Entrez, Source | tumor necrosis factor receptor superfamily, member 13B | 12179 | 0.084 | 0.0628 | No |
| 69 | CLRN3 | NA | 12238 | 0.081 | 0.0613 | No | ||
| 70 | LAD1 | NA | LAD1 Entrez, Source | ladinin 1 | 13168 | 0.046 | 0.0274 | No |
| 71 | JUNB | NA | JUNB Entrez, Source | jun B proto-oncogene | 13778 | 0.023 | 0.0052 | No |
| 72 | HSD17B2 | NA | HSD17B2 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 2 | 14388 | 0.002 | -0.0172 | No |
| 73 | FMO3 | NA | FMO3 Entrez, Source | flavin containing monooxygenase 3 | 14677 | -0.009 | -0.0277 | No |
| 74 | CALCA | NA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 15001 | -0.021 | -0.0394 | No |
| 75 | DUSP16 | NA | DUSP16 Entrez, Source | dual specificity phosphatase 16 | 15009 | -0.022 | -0.0395 | No |
| 76 | LECT1 | NA | LECT1 Entrez, Source | leukocyte cell derived chemotaxin 1 | 15777 | -0.051 | -0.0674 | No |
| 77 | PCSK2 | NA | PCSK2 Entrez, Source | proprotein convertase subtilisin/kexin type 2 | 15928 | -0.057 | -0.0725 | No |
| 78 | SEL1L3 | NA | 15966 | -0.058 | -0.0734 | No | ||
| 79 | SERPINA3 | NA | SERPINA3 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 17210 | -0.111 | -0.1183 | No |
| 80 | PHOX2B | NA | PHOX2B Entrez, Source | paired-like homeobox 2b | 17549 | -0.126 | -0.1299 | No |
| 81 | STEAP4 | NA | STEAP4 Entrez, Source | STEAP family member 4 | 17640 | -0.131 | -0.1322 | No |
| 82 | GFAP | NA | GFAP Entrez, Source | glial fibrillary acidic protein | 17858 | -0.145 | -0.1392 | No |
| 83 | DDX3Y | NA | DDX3Y Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | 18301 | -0.172 | -0.1542 | No |
| 84 | SPG21 | NA | SPG21 Entrez, Source | spastic paraplegia 21, maspardin (autosomal recessive, Mast syndrome) | 18457 | -0.182 | -0.1586 | No |
| 85 | ZDHHC14 | NA | ZDHHC14 Entrez, Source | zinc finger, DHHC-type containing 14 | 18458 | -0.182 | -0.1573 | No |
| 86 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 19170 | -0.241 | -0.1818 | No |
| 87 | APOBEC2 | NA | APOBEC2 Entrez, Source | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 | 19722 | -0.291 | -0.2000 | No |
| 88 | PRDM1 | NA | PRDM1 Entrez, Source | PR domain containing 1, with ZNF domain | 20217 | -0.343 | -0.2157 | No |
| 89 | PHOSPHO1 | NA | PHOSPHO1 Entrez, Source | phosphatase, orphan 1 | 20226 | -0.345 | -0.2135 | No |
| 90 | CAPN12 | NA | CAPN12 Entrez, Source | calpain 12 | 20446 | -0.374 | -0.2189 | No |
| 91 | CRYBG3 | NA | 20471 | -0.377 | -0.2172 | No | ||
| 92 | MFSD4 | NA | MFSD4 Entrez, Source | major facilitator superfamily domain containing 4 | 20937 | -0.443 | -0.2311 | No |
| 93 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 20994 | -0.451 | -0.2300 | No |
| 94 | NAB2 | NA | NAB2 Entrez, Source | NGFI-A binding protein 2 (EGR1 binding protein 2) | 21001 | -0.452 | -0.2270 | No |
| 95 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 21067 | -0.462 | -0.2261 | No |
| 96 | CADPS2 | NA | CADPS2 Entrez, Source | Ca2+-dependent activator protein for secretion 2 | 21163 | -0.475 | -0.2262 | No |
| 97 | ACBD6 | NA | ACBD6 Entrez, Source | acyl-Coenzyme A binding domain containing 6 | 21534 | -0.540 | -0.2360 | No |
| 98 | EFNA1 | NA | EFNA1 Entrez, Source | ephrin-A1 | 21707 | -0.572 | -0.2383 | No |
| 99 | ZNF474 | NA | ZNF474 Entrez, Source | zinc finger protein 474 | 21871 | -0.604 | -0.2400 | No |
| 100 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 21956 | -0.621 | -0.2387 | No |
| 101 | CTNNAL1 | NA | CTNNAL1 Entrez, Source | catenin (cadherin-associated protein), alpha-like 1 | 22027 | -0.633 | -0.2367 | No |
| 102 | INSM2 | NA | INSM2 Entrez, Source | insulinoma-associated 2 | 22377 | -0.702 | -0.2446 | No |
| 103 | ATP8B2 | NA | ATP8B2 Entrez, Source | ATPase, Class I, type 8B, member 2 | 22769 | -0.787 | -0.2534 | No |
| 104 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 22932 | -0.826 | -0.2535 | No |
| 105 | B3GNT2 | NA | B3GNT2 Entrez, Source | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 23106 | -0.860 | -0.2538 | No |
| 106 | PTER | NA | PTER Entrez, Source | phosphotriesterase related | 23633 | -0.988 | -0.2661 | No |
| 107 | TIMP1 | NA | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 24033 | -1.098 | -0.2730 | No |
| 108 | KDELR3 | NA | KDELR3 Entrez, Source | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 24213 | -1.153 | -0.2714 | No |
| 109 | RGL3 | NA | RGL3 Entrez, Source | ral guanine nucleotide dissociation stimulator-like 3 | 24562 | -1.267 | -0.2752 | Yes |
| 110 | PYCR1 | NA | PYCR1 Entrez, Source | pyrroline-5-carboxylate reductase 1 | 24654 | -1.294 | -0.2694 | Yes |
| 111 | ANXA2 | NA | ANXA2 Entrez, Source | annexin A2 | 24735 | -1.322 | -0.2629 | Yes |
| 112 | MPP6 | NA | MPP6 Entrez, Source | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 24804 | -1.345 | -0.2559 | Yes |
| 113 | CHAC1 | NA | CHAC1 Entrez, Source | ChaC, cation transport regulator homolog 1 (E. coli) | 25142 | -1.481 | -0.2578 | Yes |
| 114 | OSMR | NA | OSMR Entrez, Source | oncostatin M receptor | 25341 | -1.566 | -0.2539 | Yes |
| 115 | PPP1R14A | NA | PPP1R14A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 14A | 25345 | -1.568 | -0.2429 | Yes |
| 116 | CEBPB | NA | CEBPB Entrez, Source | CCAAT/enhancer binding protein (C/EBP), beta | 25505 | -1.643 | -0.2371 | Yes |
| 117 | S100A16 | NA | S100A16 Entrez, Source | S100 calcium binding protein A16 | 25580 | -1.679 | -0.2279 | Yes |
| 118 | FKBP5 | NA | FKBP5 Entrez, Source | FK506 binding protein 5 | 26509 | -2.307 | -0.2457 | Yes |
| 119 | RAI14 | NA | RAI14 Entrez, Source | retinoic acid induced 14 | 26542 | -2.334 | -0.2303 | Yes |
| 120 | TAGLN2 | NA | TAGLN2 Entrez, Source | transgelin 2 | 26560 | -2.350 | -0.2143 | Yes |
| 121 | CEBPA | NA | CEBPA Entrez, Source | CCAAT/enhancer binding protein (C/EBP), alpha | 26620 | -2.406 | -0.1994 | Yes |
| 122 | TUBB6 | NA | TUBB6 Entrez, Source | tubulin, beta 6 | 26628 | -2.414 | -0.1825 | Yes |
| 123 | TGM2 | NA | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 26716 | -2.524 | -0.1678 | Yes |
| 124 | RGNEF | NA | RGNEF Entrez, Source | - | 26786 | -2.623 | -0.1518 | Yes |
| 125 | IRF5 | NA | IRF5 Entrez, Source | interferon regulatory factor 5 | 26809 | -2.661 | -0.1337 | Yes |
| 126 | DCAF4 | NA | 26909 | -2.821 | -0.1173 | Yes | ||
| 127 | WWC1 | NA | WWC1 Entrez, Source | WW, C2 and coiled-coil domain containing 1 | 26975 | -2.960 | -0.0987 | Yes |
| 128 | FUT4 | NA | FUT4 Entrez, Source | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) | 27025 | -3.114 | -0.0785 | Yes |
| 129 | TMBIM1 | NA | TMBIM1 Entrez, Source | transmembrane BAX inhibitor motif containing 1 | 27149 | -3.545 | -0.0578 | Yes |
| 130 | EGR1 | NA | EGR1 Entrez, Source | early growth response 1 | 27274 | -4.330 | -0.0317 | Yes |
| 131 | S100A6 | NA | S100A6 Entrez, Source | S100 calcium binding protein A6 | 27314 | -4.749 | 0.0006 | Yes |
