Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | EIF4E_UP |
| Enrichment Score (ES) | -0.45140398 |
| Normalized Enrichment Score (NES) | -1.4428432 |
| Nominal p-value | 0.016460905 |
| FDR q-value | 0.18946265 |
| FWER p-Value | 0.397 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CAMK2N2 | NA | CAMK2N2 Entrez, Source | calcium/calmodulin-dependent protein kinase II inhibitor 2 | 321 | 3.045 | 0.0207 | No |
| 2 | FABP7 | NA | FABP7 Entrez, Source | fatty acid binding protein 7, brain | 323 | 3.044 | 0.0531 | No |
| 3 | MDH2 | NA | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 356 | 2.988 | 0.0838 | No |
| 4 | NDRG1 | NA | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 988 | 2.321 | 0.0854 | No |
| 5 | TP53I11 | NA | TP53I11 Entrez, Source | tumor protein p53 inducible protein 11 | 1363 | 2.062 | 0.0937 | No |
| 6 | SNTB1 | NA | SNTB1 Entrez, Source | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 2076 | 1.686 | 0.0855 | No |
| 7 | VPS28 | NA | VPS28 Entrez, Source | vacuolar protein sorting 28 homolog (S. cerevisiae) | 2126 | 1.665 | 0.1015 | No |
| 8 | CACNB3 | NA | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 2697 | 1.423 | 0.0957 | No |
| 9 | AGXT2L2 | NA | AGXT2L2 Entrez, Source | alanine-glyoxylate aminotransferase 2-like 2 | 3403 | 1.183 | 0.0824 | No |
| 10 | ATP5J2 | NA | ATP5J2 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 | 4074 | 0.966 | 0.0681 | No |
| 11 | C16orf91 | NA | 4409 | 0.881 | 0.0653 | No | ||
| 12 | JOSD1 | NA | JOSD1 Entrez, Source | Josephin domain containing 1 | 4482 | 0.865 | 0.0719 | No |
| 13 | C8orf33 | NA | C8ORF33 Entrez, Source | chromosome 8 open reading frame 33 | 4485 | 0.863 | 0.0810 | No |
| 14 | UROS | NA | UROS Entrez, Source | uroporphyrinogen III synthase (congenital erythropoietic porphyria) | 4567 | 0.847 | 0.0870 | No |
| 15 | C20orf30 | NA | C20ORF30 Entrez, Source | chromosome 20 open reading frame 30 | 4886 | 0.770 | 0.0836 | No |
| 16 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 4940 | 0.757 | 0.0897 | No |
| 17 | ITPK1 | NA | ITPK1 Entrez, Source | inositol 1,3,4-triphosphate 5/6 kinase | 5841 | 0.555 | 0.0626 | No |
| 18 | TST | NA | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 5946 | 0.539 | 0.0645 | No |
| 19 | PTS | NA | PTS Entrez, Source | 6-pyruvoyltetrahydropterin synthase | 5997 | 0.527 | 0.0683 | No |
| 20 | VPS72 | NA | VPS72 Entrez, Source | vacuolar protein sorting 72 (S. cerevisiae) | 6700 | 0.428 | 0.0471 | No |
| 21 | ACYP1 | NA | ACYP1 Entrez, Source | acylphosphatase 1, erythrocyte (common) type | 7068 | 0.390 | 0.0378 | No |
| 22 | MS4A1 | NA | MS4A1 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 1 | 7624 | 0.333 | 0.0209 | No |
| 23 | TAF11 | NA | TAF11 Entrez, Source | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 8181 | 0.286 | 0.0036 | No |
| 24 | BOLA1 | NA | BOLA1 Entrez, Source | bolA homolog 1 (E. coli) | 8694 | 0.249 | -0.0126 | No |
| 25 | STRA13 | NA | STRA13 Entrez, Source | stimulated by retinoic acid 13 homolog (mouse) | 8912 | 0.235 | -0.0180 | No |
| 26 | NEGR1 | NA | NEGR1 Entrez, Source | neuronal growth regulator 1 | 9081 | 0.225 | -0.0218 | No |
| 27 | SNRNP25 | NA | 9228 | 0.217 | -0.0249 | No | ||
| 28 | ZNF576 | NA | ZNF576 Entrez, Source | zinc finger protein 576 | 9241 | 0.217 | -0.0230 | No |
| 29 | MAPK8IP1 | NA | MAPK8IP1 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 1 | 9597 | 0.198 | -0.0339 | No |
| 30 | MRPL17 | NA | MRPL17 Entrez, Source | mitochondrial ribosomal protein L17 | 10206 | 0.170 | -0.0544 | No |
| 31 | PRSS1 | NA | PRSS1 Entrez, Source | protease, serine, 1 (trypsin 1) | 10323 | 0.164 | -0.0569 | No |
| 32 | NKX2-8 | NA | NKX2-8 Entrez, Source | NK2 transcription factor related, locus 8 (Drosophila) | 10740 | 0.144 | -0.0707 | No |
| 33 | MYH6 | NA | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 11534 | 0.109 | -0.0986 | No |
| 34 | C6orf226 | NA | 11963 | 0.092 | -0.1134 | No | ||
| 35 | CNTN4 | NA | CNTN4 Entrez, Source | contactin 4 | 12641 | 0.066 | -0.1375 | No |
| 36 | KLF8 | NA | KLF8 Entrez, Source | Kruppel-like factor 8 | 13110 | 0.049 | -0.1542 | No |
| 37 | CKMT2 | NA | CKMT2 Entrez, Source | creatine kinase, mitochondrial 2 (sarcomeric) | 13511 | 0.033 | -0.1685 | No |
| 38 | ZBED2 | NA | ZBED2 Entrez, Source | zinc finger, BED-type containing 2 | 13568 | 0.030 | -0.1703 | No |
| 39 | TALDO1 | NA | TALDO1 Entrez, Source | transaldolase 1 | 13676 | 0.027 | -0.1739 | No |
| 40 | CARTPT | NA | CARTPT Entrez, Source | CART prepropeptide | 14067 | 0.012 | -0.1881 | No |
| 41 | MGC50722 | NA | MGC50722 Entrez, Source | - | 14242 | 0.006 | -0.1944 | No |
| 42 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 14572 | -0.005 | -0.2065 | No |
| 43 | ANKRD16 | NA | ANKRD16 Entrez, Source | ankyrin repeat domain 16 | 16261 | -0.072 | -0.2677 | No |
| 44 | CHCHD1 | NA | CHCHD1 Entrez, Source | coiled-coil-helix-coiled-coil-helix domain containing 1 | 16262 | -0.072 | -0.2669 | No |
| 45 | CFHR1 | NA | CFHR1 Entrez, Source | complement factor H-related 1 | 16434 | -0.079 | -0.2724 | No |
| 46 | TMEM11 | NA | TMEM11 Entrez, Source | transmembrane protein 11 | 16449 | -0.079 | -0.2720 | No |
| 47 | BMP3 | NA | BMP3 Entrez, Source | bone morphogenetic protein 3 (osteogenic) | 16585 | -0.084 | -0.2761 | No |
| 48 | FKBP1B | NA | FKBP1B Entrez, Source | FK506 binding protein 1B, 12.6 kDa | 16827 | -0.094 | -0.2839 | No |
| 49 | KCNC2 | NA | KCNC2 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 2 | 17542 | -0.126 | -0.3088 | No |
| 50 | VIPR2 | NA | VIPR2 Entrez, Source | vasoactive intestinal peptide receptor 2 | 18050 | -0.156 | -0.3258 | No |
| 51 | FAM65C | NA | 18723 | -0.204 | -0.3483 | No | ||
| 52 | FETUB | NA | FETUB Entrez, Source | fetuin B | 18859 | -0.214 | -0.3509 | No |
| 53 | LST1 | NA | LST1 Entrez, Source | leukocyte specific transcript 1 | 19299 | -0.251 | -0.3644 | No |
| 54 | FOXD2 | NA | FOXD2 Entrez, Source | forkhead box D2 | 19435 | -0.263 | -0.3665 | No |
| 55 | TUFM | NA | TUFM Entrez, Source | Tu translation elongation factor, mitochondrial | 19645 | -0.285 | -0.3712 | No |
| 56 | DPY30 | NA | 19982 | -0.318 | -0.3801 | No | ||
| 57 | UBFD1 | NA | 20476 | -0.377 | -0.3942 | No | ||
| 58 | MON1A | NA | MON1A Entrez, Source | MON1 homolog A (yeast) | 20972 | -0.449 | -0.4076 | No |
| 59 | DNAJB5 | NA | DNAJB5 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 5 | 21144 | -0.473 | -0.4088 | No |
| 60 | PNO1 | NA | 22305 | -0.688 | -0.4441 | Yes | ||
| 61 | PMM2 | NA | PMM2 Entrez, Source | phosphomannomutase 2 | 22327 | -0.692 | -0.4375 | Yes |
| 62 | AHSA1 | NA | AHSA1 Entrez, Source | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) | 22363 | -0.699 | -0.4313 | Yes |
| 63 | UBL4A | NA | UBL4A Entrez, Source | ubiquitin-like 4A | 22413 | -0.710 | -0.4255 | Yes |
| 64 | ISOC2 | NA | ISOC2 Entrez, Source | isochorismatase domain containing 2 | 22889 | -0.816 | -0.4343 | Yes |
| 65 | UCHL3 | NA | UCHL3 Entrez, Source | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | 22941 | -0.828 | -0.4273 | Yes |
| 66 | RGS3 | NA | RGS3 Entrez, Source | regulator of G-protein signalling 3 | 23098 | -0.858 | -0.4239 | Yes |
| 67 | MRPL30 | NA | MRPL30 Entrez, Source | mitochondrial ribosomal protein L30 | 23195 | -0.877 | -0.4180 | Yes |
| 68 | RSAD1 | NA | RSAD1 Entrez, Source | radical S-adenosyl methionine domain containing 1 | 23198 | -0.879 | -0.4087 | Yes |
| 69 | SLC25A30 | NA | SLC25A30 Entrez, Source | solute carrier family 25, member 30 | 23263 | -0.895 | -0.4016 | Yes |
| 70 | ATP8B3 | NA | ATP8B3 Entrez, Source | ATPase, Class I, type 8B, member 3 | 23292 | -0.899 | -0.3930 | Yes |
| 71 | DOM3Z | NA | DOM3Z Entrez, Source | dom-3 homolog Z (C. elegans) | 23659 | -0.995 | -0.3958 | Yes |
| 72 | EIF4A3 | NA | 23828 | -1.045 | -0.3908 | Yes | ||
| 73 | C4orf37 | NA | 23854 | -1.050 | -0.3806 | Yes | ||
| 74 | TAX1BP3 | NA | TAX1BP3 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 23894 | -1.063 | -0.3707 | Yes |
| 75 | MRPS35 | NA | MRPS35 Entrez, Source | mitochondrial ribosomal protein S35 | 24057 | -1.105 | -0.3648 | Yes |
| 76 | METTL1 | NA | METTL1 Entrez, Source | methyltransferase like 1 | 24091 | -1.114 | -0.3541 | Yes |
| 77 | NPM3 | NA | NPM3 Entrez, Source | nucleophosmin/nucleoplasmin, 3 | 24150 | -1.135 | -0.3442 | Yes |
| 78 | DEDD | NA | DEDD Entrez, Source | death effector domain containing | 24186 | -1.145 | -0.3332 | Yes |
| 79 | FN3KRP | NA | FN3KRP Entrez, Source | - | 24708 | -1.312 | -0.3384 | Yes |
| 80 | LAMC3 | NA | LAMC3 Entrez, Source | laminin, gamma 3 | 25186 | -1.495 | -0.3399 | Yes |
| 81 | NUDCD2 | NA | NUDCD2 Entrez, Source | NudC domain containing 2 | 25308 | -1.552 | -0.3278 | Yes |
| 82 | PFDN2 | NA | PFDN2 Entrez, Source | prefoldin subunit 2 | 25480 | -1.630 | -0.3167 | Yes |
| 83 | C6orf108 | NA | C6ORF108 Entrez, Source | chromosome 6 open reading frame 108 | 25523 | -1.652 | -0.3006 | Yes |
| 84 | MTX2 | NA | MTX2 Entrez, Source | metaxin 2 | 25531 | -1.654 | -0.2833 | Yes |
| 85 | SNX8 | NA | SNX8 Entrez, Source | sorting nexin 8 | 25538 | -1.658 | -0.2658 | Yes |
| 86 | NOP16 | NA | 25738 | -1.757 | -0.2544 | Yes | ||
| 87 | FBXO4 | NA | FBXO4 Entrez, Source | F-box protein 4 | 25771 | -1.778 | -0.2366 | Yes |
| 88 | FAM117A | NA | FAM117A Entrez, Source | family with sequence similarity 117, member A | 25993 | -1.912 | -0.2243 | Yes |
| 89 | MAP2K3 | NA | MAP2K3 Entrez, Source | mitogen-activated protein kinase kinase 3 | 26003 | -1.917 | -0.2042 | Yes |
| 90 | HAUS7 | NA | 26102 | -1.981 | -0.1866 | Yes | ||
| 91 | GEMIN6 | NA | GEMIN6 Entrez, Source | gem (nuclear organelle) associated protein 6 | 26106 | -1.984 | -0.1656 | Yes |
| 92 | SRXN1 | NA | SRXN1 Entrez, Source | sulfiredoxin 1 homolog (S. cerevisiae) | 26580 | -2.366 | -0.1577 | Yes |
| 93 | PPCS | NA | PPCS Entrez, Source | phosphopantothenoylcysteine synthetase | 26643 | -2.439 | -0.1340 | Yes |
| 94 | C16orf53 | NA | C16ORF53 Entrez, Source | chromosome 16 open reading frame 53 | 26715 | -2.523 | -0.1097 | Yes |
| 95 | SSSCA1 | NA | SSSCA1 Entrez, Source | Sjogren's syndrome/scleroderma autoantigen 1 | 26720 | -2.529 | -0.0829 | Yes |
| 96 | OSBPL10 | NA | OSBPL10 Entrez, Source | oxysterol binding protein-like 10 | 26811 | -2.666 | -0.0577 | Yes |
| 97 | GTF2H5 | NA | GTF2H5 Entrez, Source | general transcription factor IIH, polypeptide 5 | 26979 | -2.976 | -0.0321 | Yes |
| 98 | FBXL13 | NA | FBXL13 Entrez, Source | F-box and leucine-rich repeat protein 13 | 27257 | -4.212 | 0.0026 | Yes |
