Datasetexpression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls
#wt_versus_radiation.mainSample.cls
#wt_versus_radiation_repos
PhenotypemainSample.cls#wt_versus_radiation_repos
Upregulated in class1
GeneSetKRAS.AMP.LUNG_UP.V1_UP
Enrichment Score (ES)0.3753316
Normalized Enrichment Score (NES)1.5990342
Nominal p-value0.0
FDR q-value0.009951914
FWER p-Value0.099
Table: GSEA Results Summary



Fig 1: Enrichment plot: KRAS.AMP.LUNG_UP.V1_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1NOVA1NANOVA1
Entrez,  Source
neuro-oncological ventral antigen 12693.1370.0256Yes
2NPAS3NANPAS3
Entrez,  Source
neuronal PAS domain protein 32833.1110.0603Yes
3MAN1C1NAMAN1C1
Entrez,  Source
mannosidase, alpha, class 1C, member 14232.9000.0880Yes
4KCNC1NAKCNC1
Entrez,  Source
potassium voltage-gated channel, Shaw-related subfamily, member 16982.5790.1072Yes
5HSPA6NAHSPA6
Entrez,  Source
heat shock 70kDa protein 6 (HSP70B')6992.5780.1363Yes
6C3AR1NAC3AR1
Entrez,  Source
complement component 3a receptor 17182.5530.1646Yes
7ST3GAL6NAST3GAL6
Entrez,  Source
ST3 beta-galactoside alpha-2,3-sialyltransferase 69232.3700.1839Yes
8LPLNALPL
Entrez,  Source
lipoprotein lipase10592.2720.2046Yes
9EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)12622.1270.2213Yes
10ABCC6NAABCC6
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 614002.0360.2393Yes
11SPP1NASPP1
Entrez,  Source
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)16471.8970.2517Yes
12MMP15NAMMP15
Entrez,  Source
matrix metallopeptidase 15 (membrane-inserted)16631.8920.2725Yes
13SLC26A4NASLC26A4
Entrez,  Source
solute carrier family 26, member 418341.8070.2867Yes
14MCF2LNAMCF2L
Entrez,  Source
MCF.2 cell line derived transforming sequence-like22251.6240.2908Yes
15AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 225551.4790.2954Yes
16FKBP6NAFKBP6
Entrez,  Source
FK506 binding protein 6, 36kDa26211.4520.3095Yes
17NDOR1NANDOR1
Entrez,  Source
NADPH dependent diflavin oxidoreductase 128091.3830.3183Yes
18FAM174BNA28251.3770.3333Yes
19TUBA8NATUBA8
Entrez,  Source
tubulin, alpha 829651.3200.3431Yes
20HIST1H2BBNAHIST1H2BB
Entrez,  Source
histone cluster 1, H2bb34581.1660.3382Yes
21DYNC1I1NADYNC1I1
Entrez,  Source
dynein, cytoplasmic 1, intermediate chain 136021.1150.3456Yes
22ZNF257NAZNF257
Entrez,  Source
zinc finger protein 25736331.1050.3570Yes
23HGFACNAHGFAC
Entrez,  Source
HGF activator37771.0590.3637Yes
24ZNF835NA37871.0550.3753Yes
25FGF7NAFGF7
Entrez,  Source
fibroblast growth factor 7 (keratinocyte growth factor)41200.9530.3739No
26SEMA3ENASEMA3E
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E45170.8570.3690No
27TTLL3NATTLL3
Entrez,  Source
tubulin tyrosine ligase-like family, member 352590.6740.3494No
28CRYBA1NACRYBA1
Entrez,  Source
crystallin, beta A153360.6520.3540No
29MYOZ1NAMYOZ1
Entrez,  Source
myozenin 159170.5430.3388No
30RESTNAREST
Entrez,  Source
RE1-silencing transcription factor59340.5400.3444No
31TMEM35NATMEM35
Entrez,  Source
transmembrane protein 3561680.5020.3415No
32CLEC4ANACLEC4A
Entrez,  Source
C-type lectin domain family 4, member A66420.4360.3290No
33GNGT2NAGNGT2
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 267110.4270.3313No
34HSF1NAHSF1
Entrez,  Source
heat shock transcription factor 167250.4260.3357No
35EFNA2NAEFNA2
Entrez,  Source
ephrin-A267280.4250.3404No
36GPR6NAGPR6
Entrez,  Source
G protein-coupled receptor 669690.4000.3361No
37CA5ANACA5A
Entrez,  Source
carbonic anhydrase VA, mitochondrial71380.3820.3343No
38C8orf39NAC8ORF39
Entrez,  Source
chromosome 8 open reading frame 3974010.3540.3287No
39C22orf43NA74340.3510.3315No
40GABRR1NAGABRR1
Entrez,  Source
gamma-aminobutyric acid (GABA) receptor, rho 174890.3450.3334No
41NGFNA75750.3380.3341No
42EFCAB6NA79230.3070.3248No
43DUSP9NADUSP9
Entrez,  Source
dual specificity phosphatase 980760.2940.3225No
44HIST1H2BNNAHIST1H2BN
Entrez,  Source
histone cluster 1, H2bn85230.2620.3091No
45CELA2BNA88790.2370.2987No
46ASIPNAASIP
Entrez,  Source
agouti signaling protein, nonagouti homolog (mouse)91220.2230.2923No
47PAX4NAPAX4
Entrez,  Source
paired box gene 498360.1860.2682No
48BMPERNABMPER
Entrez,  Source
BMP binding endothelial regulator98490.1860.2699No
49ATXN3LNAATXN3L
Entrez,  Source
ataxin 3-like100310.1770.2652No
50GABRR2NAGABRR2
Entrez,  Source
gamma-aminobutyric acid (GABA) receptor, rho 2101780.1710.2618No
51OPN1SWNAOPN1SW
Entrez,  Source
opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)102670.1660.2605No
52TNNT2NATNNT2
Entrez,  Source
troponin T type 2 (cardiac)107480.1440.2444No
53ST8SIA2NAST8SIA2
Entrez,  Source
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2109670.1340.2379No
54SSTR1NASSTR1
Entrez,  Source
somatostatin receptor 1110730.1290.2355No
55GIPNAGIP
Entrez,  Source
gastric inhibitory polypeptide111380.1260.2346No
56IL26NAIL26
Entrez,  Source
interleukin 26111570.1250.2354No
57HCN4NAHCN4
Entrez,  Source
hyperpolarization activated cyclic nucleotide-gated potassium channel 4112850.1180.2320No
58GATA1NAGATA1
Entrez,  Source
GATA binding protein 1 (globin transcription factor 1)113090.1170.2325No
59F13A1NAF13A1
Entrez,  Source
coagulation factor XIII, A1 polypeptide115230.1100.2259No
60HSD3B2NAHSD3B2
Entrez,  Source
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2116460.1040.2226No
61SPTA1NASPTA1
Entrez,  Source
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)117880.0980.2185No
62DLX5NADLX5
Entrez,  Source
distal-less homeobox 5120500.0880.2099No
63NMUR1NANMUR1
Entrez,  Source
neuromedin U receptor 1121270.0860.2081No
64DOCK3NADOCK3
Entrez,  Source
dedicator of cytokinesis 3123470.0770.2009No
65PRKG2NAPRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II123610.0760.2013No
66CCT8L2NA124120.0740.2003No
67CD247NACD247
Entrez,  Source
CD247 molecule125300.0700.1968No
68TDRD1NATDRD1
Entrez,  Source
tudor domain containing 1125430.0700.1972No
69NPBWR2NANPBWR2
Entrez,  Source
neuropeptides B/W receptor 2125810.0680.1966No
70MAGEB1NAMAGEB1
Entrez,  Source
melanoma antigen family B, 1132000.0450.1744No
71NPHS1NANPHS1
Entrez,  Source
nephrosis 1, congenital, Finnish type (nephrin)133210.0400.1704No
72CLSTN2NACLSTN2
Entrez,  Source
calsyntenin 2133980.0370.1680No
73XPNPEP2NAXPNPEP2
Entrez,  Source
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound136740.0270.1582No
74C11orf16NAC11ORF16
Entrez,  Source
chromosome 11 open reading frame 16139750.0160.1474No
75OPRK1NAOPRK1
Entrez,  Source
opioid receptor, kappa 1140200.0140.1459No
76GPR44NAGPR44
Entrez,  Source
G protein-coupled receptor 44140240.0140.1460No
77FCER1GNAFCER1G
Entrez,  Source
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide141280.0110.1423No
78LY75NALY75
Entrez,  Source
lymphocyte antigen 75142450.0060.1381No
79VENTXNAVENTX
Entrez,  Source
VENT homeobox homolog (Xenopus laevis)143440.0030.1345No
80SLC6A6NASLC6A6
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, taurine), member 614876-0.0160.1152No
81PIWIL1NAPIWIL1
Entrez,  Source
piwi-like 1 (Drosophila)14979-0.0200.1117No
82PNMA3NAPNMA3
Entrez,  Source
paraneoplastic antigen MA315190-0.0290.1043No
83CYP3A7NACYP3A7
Entrez,  Source
cytochrome P450, family 3, subfamily A, polypeptide 715308-0.0330.1003No
84CLEC5ANACLEC5A
Entrez,  Source
C-type lectin domain family 5, member A15453-0.0390.0955No
85VTNNAVTN
Entrez,  Source
vitronectin15462-0.0390.0956No
86FCRL2NAFCRL2
Entrez,  Source
Fc receptor-like 215522-0.0420.0939No
87GCKRNAGCKR
Entrez,  Source
glucokinase (hexokinase 4) regulator15562-0.0430.0930No
88HECW1NAHECW1
Entrez,  Source
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 115661-0.0470.0899No
89SLC25A31NASLC25A31
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 3115810-0.0520.0851No
90GRPNAGRP
Entrez,  Source
gastrin-releasing peptide15949-0.0570.0806No
91AFPNAAFP
Entrez,  Source
alpha-fetoprotein15994-0.0600.0797No
92GPR25NAGPR25
Entrez,  Source
G protein-coupled receptor 2516232-0.0710.0718No
93CAMK1GNACAMK1G
Entrez,  Source
calcium/calmodulin-dependent protein kinase IG16393-0.0770.0668No
94GABRA6NAGABRA6
Entrez,  Source
gamma-aminobutyric acid (GABA) A receptor, alpha 616571-0.0840.0612No
95ALLCNAALLC
Entrez,  Source
allantoicase16670-0.0880.0586No
96CEBPENACEBPE
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), epsilon17079-0.1050.0448No
97RAB30NARAB30
Entrez,  Source
RAB30, member RAS oncogene family17240-0.1120.0402No
98SOX12NASOX12
Entrez,  Source
SRY (sex determining region Y)-box 1217247-0.1120.0412No
99BTG4NABTG4
Entrez,  Source
B-cell translocation gene 417352-0.1170.0387No
100CD3ENACD3E
Entrez,  Source
CD3e molecule, epsilon (CD3-TCR complex)17403-0.1200.0382No
101SPINK1NASPINK1
Entrez,  Source
serine peptidase inhibitor, Kazal type 118001-0.1530.0180No
102DEFA5NADEFA5
Entrez,  Source
defensin, alpha 5, Paneth cell-specific18021-0.1540.0191No
103C10orf81NAC10ORF81
Entrez,  Source
chromosome 10 open reading frame 8118304-0.1720.0106No
104ABCG5NAABCG5
Entrez,  Source
ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1)18420-0.1800.0084No
105SLAMF1NASLAMF1
Entrez,  Source
signaling lymphocytic activation molecule family member 118553-0.1890.0057No
106LENEPNALENEP
Entrez,  Source
lens epithelial protein18750-0.2060.0009No
107FCER1ANAFCER1A
Entrez,  Source
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide18996-0.227-0.0056No
108PAGE4NAPAGE4
Entrez,  Source
P antigen family, member 4 (prostate associated)19238-0.247-0.0117No
109CFHR5NACFHR5
Entrez,  Source
complement factor H-related 519295-0.251-0.0109No
110C8BNAC8B
Entrez,  Source
complement component 8, beta polypeptide19296-0.251-0.0080No
111CSN2NACSN2
Entrez,  Source
casein beta19482-0.268-0.0118No
112KLK14NAKLK14
Entrez,  Source
kallikrein 1419590-0.279-0.0126No
113SLC7A9NASLC7A9
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 920132-0.335-0.0287No
114RCAN2NA20320-0.358-0.0315No
115CCDC57NACCDC57
Entrez,  Source
coiled-coil domain containing 5720364-0.364-0.0290No
116GPR68NAGPR68
Entrez,  Source
G protein-coupled receptor 6820646-0.398-0.0348No
117ATG10NAATG10
Entrez,  Source
ATG10 autophagy related 10 homolog (S. cerevisiae)20685-0.404-0.0316No
118EFNA3NAEFNA3
Entrez,  Source
ephrin-A320716-0.409-0.0281No
119HPRNAHPR
Entrez,  Source
haptoglobin-related protein20926-0.441-0.0308No
120CLSTN3NACLSTN3
Entrez,  Source
calsyntenin 320943-0.444-0.0264No
121OTORNAOTOR
Entrez,  Source
otoraplin21148-0.474-0.0285No
122OSBP2NAOSBP2
Entrez,  Source
oxysterol binding protein 221630-0.556-0.0399No
123RPL23AP53NA21648-0.560-0.0342No
124CCL11NACCL11
Entrez,  Source
chemokine (C-C motif) ligand 1121975-0.625-0.0391No
125NPHP1NANPHP1
Entrez,  Source
nephronophthisis 1 (juvenile)21983-0.626-0.0323No
126SLC2A4NASLC2A4
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 422083-0.645-0.0286No
127NELL2NANELL2
Entrez,  Source
NEL-like 2 (chicken)22466-0.721-0.0345No
128SDCCAG8NASDCCAG8
Entrez,  Source
serologically defined colon cancer antigen 822608-0.756-0.0311No
129JAK3NAJAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)23405-0.927-0.0499No
130B3GNTL1NAB3GNTL1
Entrez,  Source
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 125465-1.623-0.1072No
131HSPA1LNAHSPA1L
Entrez,  Source
heat shock 70kDa protein 1-like25695-1.738-0.0960No
132C8orf59NAC8ORF59
Entrez,  Source
chromosome 8 open reading frame 5926272-2.107-0.0933No
133MAGEA12NAMAGEA12
Entrez,  Source
melanoma antigen family A, 1226850-2.751-0.0834No
134FAM155BNA27228-3.985-0.0522No
135MAGEA6NAMAGEA6
Entrez,  Source
melanoma antigen family A, 627329-4.936-0.0000No
Table: GSEA details [plain text format]



Fig 2: KRAS.AMP.LUNG_UP.V1_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KRAS.AMP.LUNG_UP.V1_UP: Random ES distribution   
Gene set null distribution of ES for KRAS.AMP.LUNG_UP.V1_UP