Datasetexpression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls
#wt_versus_radiation.mainSample.cls
#wt_versus_radiation_repos
PhenotypemainSample.cls#wt_versus_radiation_repos
Upregulated in class1
GeneSetKRAS.LUNG_UP.V1_DN
Enrichment Score (ES)0.4538903
Normalized Enrichment Score (NES)1.7478865
Nominal p-value0.0
FDR q-value0.0047248383
FWER p-Value0.014
Table: GSEA Results Summary



Fig 1: Enrichment plot: KRAS.LUNG_UP.V1_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1GAS1NAGAS1
Entrez,  Source
growth arrest-specific 114.3180.0414Yes
2IGFBP2NAIGFBP2
Entrez,  Source
insulin-like growth factor binding protein 2, 36kDa373.7440.0760Yes
3SCRG1NASCRG1
Entrez,  Source
-503.6560.1107Yes
4CRYABNACRYAB
Entrez,  Source
crystallin, alpha B2033.2640.1364Yes
5VAV3NAVAV3
Entrez,  Source
vav 3 oncogene3193.0470.1614Yes
6LMO1NALMO1
Entrez,  Source
LIM domain only 1 (rhombotin 1)4142.9070.1858Yes
7METTL7ANAMETTL7A
Entrez,  Source
methyltransferase like 7A4332.8890.2129Yes
8MEGF8NAMEGF8
Entrez,  Source
multiple EGF-like-domains 87862.4890.2238Yes
9RAG1NARAG1
Entrez,  Source
recombination activating gene 18422.4400.2452Yes
10ZNF862NA9922.3200.2620Yes
11BBOX1NABBOX1
Entrez,  Source
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 110122.3100.2835Yes
12HEY2NAHEY2
Entrez,  Source
hairy/enhancer-of-split related with YRPW motif 210192.3060.3054Yes
13MAP3K1NAMAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 111392.2200.3223Yes
14GABRB1NAGABRB1
Entrez,  Source
gamma-aminobutyric acid (GABA) A receptor, beta 112742.1190.3377Yes
15CDKN1CNACDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)13172.0890.3562Yes
16NGFRNANGFR
Entrez,  Source
nerve growth factor receptor (TNFR superfamily, member 16)16171.9120.3636Yes
17OLFML2ANAOLFML2A
Entrez,  Source
olfactomedin-like 2A17001.8710.3785Yes
18PROM1NAPROM1
Entrez,  Source
prominin 118951.7780.3884Yes
19PPFIBP2NAPPFIBP2
Entrez,  Source
PTPRF interacting protein, binding protein 2 (liprin beta 2)20151.7160.4005Yes
20NYNRINNA23401.5800.4038Yes
21TSC22D4NATSC22D4
Entrez,  Source
TSC22 domain family, member 425161.5000.4117Yes
22EPHB3NAEPHB3
Entrez,  Source
EPH receptor B331291.2650.4013Yes
23PIK3C2BNAPIK3C2B
Entrez,  Source
phosphoinositide-3-kinase, class 2, beta polypeptide33751.1920.4038Yes
24PALMNAPALM
Entrez,  Source
paralemmin35281.1450.4092Yes
25PDE6BNAPDE6B
Entrez,  Source
phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)36241.1080.4163Yes
26AKR1B10NAAKR1B10
Entrez,  Source
aldo-keto reductase family 1, member B10 (aldose reductase)36451.1000.4261Yes
27STAG3L1NA36881.0850.4350Yes
28ACHENAACHE
Entrez,  Source
acetylcholinesterase (Yt blood group)40290.9780.4319Yes
29RTP4NARTP4
Entrez,  Source
receptor transporter protein 441590.9420.4362Yes
30MAP2K6NAMAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 642000.9320.4436Yes
31TFNATF
Entrez,  Source
transferrin45010.8610.4409Yes
32PRODHNAPRODH
Entrez,  Source
proline dehydrogenase (oxidase) 147440.8020.4397Yes
33CXCL14NACXCL14
Entrez,  Source
chemokine (C-X-C motif) ligand 1449870.7460.4379Yes
34MAFBNAMAFB
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)51150.7160.4401Yes
35EMID1NAEMID1
Entrez,  Source
EMI domain containing 151340.7120.4463Yes
36AKAP6NAAKAP6
Entrez,  Source
A kinase (PRKA) anchor protein 651560.7070.4523Yes
37THAP9NATHAP9
Entrez,  Source
THAP domain containing 953550.6490.4512Yes
38GPR45NAGPR45
Entrez,  Source
G protein-coupled receptor 4556200.5940.4472Yes
39INPP5DNAINPP5D
Entrez,  Source
inositol polyphosphate-5-phosphatase, 145kDa57140.5760.4493Yes
40ADD2NAADD2
Entrez,  Source
adducin 2 (beta)57400.5720.4539Yes
41POSTNNAPOSTN
Entrez,  Source
periostin, osteoblast specific factor61600.5030.4433No
42CLCA4NACLCA4
Entrez,  Source
chloride channel, calcium activated, family member 464610.4570.4367No
43IVLNAIVL
Entrez,  Source
involucrin68360.4150.4269No
44CDH12NACDH12
Entrez,  Source
cadherin 12, type 2 (N-cadherin 2)69320.4040.4273No
45HTR1BNAHTR1B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1B70980.3860.4249No
46FMO2NAFMO2
Entrez,  Source
flavin containing monooxygenase 2 (non-functional)72130.3740.4243No
47PROCNAPROC
Entrez,  Source
protein C (inactivator of coagulation factors Va and VIIIa)74230.3520.4200No
48COL2A1NACOL2A1
Entrez,  Source
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)74530.3490.4223No
49RHCGNARHCG
Entrez,  Source
Rh family, C glycoprotein75310.3410.4227No
50ERGNAERG
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog (avian)79550.3040.4101No
51CCDC132NACCDC132
Entrez,  Source
coiled-coil domain containing 13286070.2560.3886No
52CYP4B1NACYP4B1
Entrez,  Source
cytochrome P450, family 4, subfamily B, polypeptide 188690.2380.3813No
53TRIM48NATRIM48
Entrez,  Source
tripartite motif-containing 4889140.2350.3819No
54SCGB1A1NASCGB1A1
Entrez,  Source
secretoglobin, family 1A, member 1 (uteroglobin)92160.2180.3729No
55S100A12NAS100A12
Entrez,  Source
S100 calcium binding protein A1294580.2060.3661No
56KRT13NAKRT13
Entrez,  Source
keratin 1396390.1950.3613No
57CBLNACBL
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence97690.1900.3584No
58LGALS7NALGALS7
Entrez,  Source
lectin, galactoside-binding, soluble, 7 (galectin 7)98380.1860.3577No
59PLCH2NAPLCH2
Entrez,  Source
phospholipase C, eta 298840.1840.3578No
60AKAP4NAAKAP4
Entrez,  Source
A kinase (PRKA) anchor protein 4102390.1680.3464No
61ACPPNAACPP
Entrez,  Source
acid phosphatase, prostate104140.1600.3415No
62BBC3NABBC3
Entrez,  Source
BCL2 binding component 3105530.1530.3379No
63PPYR1NAPPYR1
Entrez,  Source
pancreatic polypeptide receptor 1110790.1280.3198No
64SGCDNASGCD
Entrez,  Source
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)111070.1270.3200No
65SLC6A9NASLC6A9
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, glycine), member 9112570.1200.3157No
66KRT16NAKRT16
Entrez,  Source
keratin 16 (focal non-epidermolytic palmoplantar keratoderma)114080.1130.3113No
67CD248NACD248
Entrez,  Source
CD248 molecule, endosialin121020.0870.2866No
68DEFB1NADEFB1
Entrez,  Source
defensin, beta 1121650.0840.2852No
69CD22NACD22
Entrez,  Source
CD22 molecule122510.0810.2828No
70IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha123990.0750.2781No
71MORC1NAMORC1
Entrez,  Source
MORC family CW-type zinc finger 1124810.0720.2758No
72TRGV7NATRGV7
Entrez,  Source
T cell receptor gamma variable 7125750.0680.2731No
73CALML5NACALML5
Entrez,  Source
calmodulin-like 5130060.0530.2578No
74VPREB1NAVPREB1
Entrez,  Source
pre-B lymphocyte gene 1130410.0510.2570No
75RDH16NARDH16
Entrez,  Source
retinol dehydrogenase 16 (all-trans)134010.0370.2442No
76ADORA3NAADORA3
Entrez,  Source
adenosine A3 receptor135090.0330.2405No
77CDH16NACDH16
Entrez,  Source
cadherin 16, KSP-cadherin137440.0240.2322No
78GALNT8NAGALNT8
Entrez,  Source
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)138970.0180.2267No
79KRT4NAKRT4
Entrez,  Source
keratin 4139460.0170.2251No
80HAAONAHAAO
Entrez,  Source
3-hydroxyanthranilate 3,4-dioxygenase139590.0170.2249No
81MXRA8NAMXRA8
Entrez,  Source
matrix-remodelling associated 8140080.0150.2232No
82KRT1NAKRT1
Entrez,  Source
keratin 1 (epidermolytic hyperkeratosis)142060.0080.2161No
83UPK3BNAUPK3B
Entrez,  Source
uroplakin 3B143390.0030.2112No
84SLC39A2NASLC39A2
Entrez,  Source
solute carrier family 39 (zinc transporter), member 214483-0.0020.2060No
85GDNFNAGDNF
Entrez,  Source
glial cell derived neurotrophic factor14707-0.0100.1979No
86CACNA1FNACACNA1F
Entrez,  Source
calcium channel, voltage-dependent, alpha 1F subunit14776-0.0120.1955No
87ALDH3B2NAALDH3B2
Entrez,  Source
aldehyde dehydrogenase 3 family, member B214888-0.0160.1916No
88APOBEC3ANAAPOBEC3A
Entrez,  Source
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A15006-0.0210.1875No
89TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1015485-0.0400.1703No
90ZNF750NAZNF750
Entrez,  Source
zinc finger protein 75015668-0.0470.1641No
91SH3BP1NASH3BP1
Entrez,  Source
SH3-domain binding protein 115694-0.0480.1636No
92KLK7NAKLK7
Entrez,  Source
kallikrein 7 (chymotryptic, stratum corneum)15820-0.0530.1595No
93OR3A3NAOR3A3
Entrez,  Source
olfactory receptor, family 3, subfamily A, member 315866-0.0540.1584No
94KLK12NAKLK12
Entrez,  Source
kallikrein 1216052-0.0620.1522No
95SCN10ANASCN10A
Entrez,  Source
sodium channel, voltage-gated, type X, alpha16173-0.0680.1484No
96LOC57399NALOC57399
Entrez,  Source
-16453-0.0790.1389No
97CCR2NACCR2
Entrez,  Source
chemokine (C-C motif) receptor 216547-0.0830.1363No
98CYP2C18NACYP2C18
Entrez,  Source
cytochrome P450, family 2, subfamily C, polypeptide 1816706-0.0890.1313No
99KLK11NAKLK11
Entrez,  Source
kallikrein 1116791-0.0930.1291No
100SLC6A14NASLC6A14
Entrez,  Source
solute carrier family 6 (amino acid transporter), member 1417324-0.1160.1107No
101PLA2G10NAPLA2G10
Entrez,  Source
phospholipase A2, group X17383-0.1190.1097No
102KRT15NAKRT15
Entrez,  Source
keratin 1517642-0.1310.1015No
103C6orf64NAC6ORF64
Entrez,  Source
chromosome 6 open reading frame 6417783-0.1390.0976No
104CYP26B1NACYP26B1
Entrez,  Source
cytochrome P450, family 26, subfamily B, polypeptide 117875-0.1450.0957No
105TRHDENATRHDE
Entrez,  Source
thyrotropin-releasing hormone degrading enzyme17887-0.1460.0967No
106SOX30NASOX30
Entrez,  Source
SRY (sex determining region Y)-box 3018192-0.1650.0871No
107S100A7NAS100A7
Entrez,  Source
S100 calcium binding protein A718221-0.1670.0877No
108SERPINB13NASERPINB13
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 1318338-0.1740.0851No
109RYR1NARYR1
Entrez,  Source
ryanodine receptor 1 (skeletal)18403-0.1780.0844No
110IHHNAIHH
Entrez,  Source
Indian hedgehog homolog (Drosophila)18476-0.1840.0835No
111CHRM5NACHRM5
Entrez,  Source
cholinergic receptor, muscarinic 518788-0.2090.0741No
112WNT16NAWNT16
Entrez,  Source
wingless-type MMTV integration site family, member 1619151-0.2390.0631No
113MC5RNAMC5R
Entrez,  Source
melanocortin 5 receptor19421-0.2620.0557No
114LY6DNALY6D
Entrez,  Source
lymphocyte antigen 6 complex, locus D19787-0.2980.0452No
115SPRR3NASPRR3
Entrez,  Source
small proline-rich protein 319850-0.3050.0458No
116CALML3NACALML3
Entrez,  Source
calmodulin-like 320178-0.3400.0370No
117GPNMBNAGPNMB
Entrez,  Source
glycoprotein (transmembrane) nmb20342-0.3610.0345No
118SLC3A1NASLC3A1
Entrez,  Source
120428-0.3710.0349No
119LYPD3NALYPD3
Entrez,  Source
LY6/PLAUR domain containing 320456-0.3750.0375No
120COL19A1NACOL19A1
Entrez,  Source
collagen, type XIX, alpha 120601-0.3930.0360No
121SCARF1NASCARF1
Entrez,  Source
scavenger receptor class F, member 120922-0.4400.0285No
122GLYATNAGLYAT
Entrez,  Source
glycine-N-acyltransferase21048-0.4600.0283No
123SRD5A3NA21591-0.5510.0136No
124SERPINB4NASERPINB4
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 422268-0.681-0.0047No
125KLK8NAKLK8
Entrez,  Source
kallikrein 8 (neuropsin/ovasin)22369-0.699-0.0016No
126TGM1NATGM1
Entrez,  Source
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)22653-0.766-0.0047No
127RAB40ALNARAB40AL
Entrez,  Source
RAB40A, member RAS oncogene family-like22977-0.836-0.0086No
128SERPINB3NASERPINB3
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 323022-0.843-0.0021No
129C11orf80NA24107-1.122-0.0312No
130COBLNACOBL
Entrez,  Source
cordon-bleu homolog (mouse)24195-1.147-0.0234No
131DHX58NA24343-1.193-0.0173No
132CRABP2NACRABP2
Entrez,  Source
cellular retinoic acid binding protein 224956-1.400-0.0264No
133SPTBN2NASPTBN2
Entrez,  Source
spectrin, beta, non-erythrocytic 225615-1.695-0.0344No
134FAM164CNA25732-1.754-0.0218No
135PSORS1C1NAPSORS1C1
Entrez,  Source
psoriasis susceptibility 1 candidate 125902-1.858-0.0102No
136HTR1DNAHTR1D
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1D26209-2.065-0.0016No
137SH3GL3NASH3GL3
Entrez,  Source
SH3-domain GRB2-like 326398-2.2140.0127No
138PTPRUNAPTPRU
Entrez,  Source
protein tyrosine phosphatase, receptor type, U26431-2.2400.0330No
Table: GSEA details [plain text format]



Fig 2: KRAS.LUNG_UP.V1_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KRAS.LUNG_UP.V1_DN: Random ES distribution   
Gene set null distribution of ES for KRAS.LUNG_UP.V1_DN