Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | MEL18_DN.V1_UP |
| Enrichment Score (ES) | -0.3345415 |
| Normalized Enrichment Score (NES) | -1.2624029 |
| Nominal p-value | 0.07862903 |
| FDR q-value | 0.23117906 |
| FWER p-Value | 0.828 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ADM | NA | ADM Entrez, Source | adrenomedullin | 62 | 3.599 | 0.0176 | No |
| 2 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 130 | 3.400 | 0.0338 | No |
| 3 | LRIG1 | NA | LRIG1 Entrez, Source | leucine-rich repeats and immunoglobulin-like domains 1 | 137 | 3.386 | 0.0523 | No |
| 4 | VEGFA | NA | 162 | 3.331 | 0.0698 | No | ||
| 5 | CD97 | NA | CD97 Entrez, Source | CD97 molecule | 187 | 3.291 | 0.0871 | No |
| 6 | CSPG4 | NA | CSPG4 Entrez, Source | chondroitin sulfate proteoglycan 4 (melanoma-associated) | 366 | 2.976 | 0.0969 | No |
| 7 | ITGB8 | NA | ITGB8 Entrez, Source | integrin, beta 8 | 394 | 2.934 | 0.1121 | No |
| 8 | TMEM51 | NA | TMEM51 Entrez, Source | transmembrane protein 51 | 440 | 2.881 | 0.1263 | No |
| 9 | LEPREL2 | NA | LEPREL2 Entrez, Source | leprecan-like 2 | 691 | 2.587 | 0.1314 | No |
| 10 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 718 | 2.553 | 0.1445 | No |
| 11 | FJX1 | NA | FJX1 Entrez, Source | four jointed box 1 (Drosophila) | 759 | 2.512 | 0.1569 | No |
| 12 | TNFAIP6 | NA | TNFAIP6 Entrez, Source | tumor necrosis factor, alpha-induced protein 6 | 885 | 2.401 | 0.1656 | No |
| 13 | LPL | NA | LPL Entrez, Source | lipoprotein lipase | 1059 | 2.272 | 0.1717 | No |
| 14 | CHST3 | NA | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 1242 | 2.138 | 0.1768 | No |
| 15 | CACNG4 | NA | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 1243 | 2.138 | 0.1886 | No |
| 16 | COL16A1 | NA | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 1355 | 2.070 | 0.1959 | No |
| 17 | HAS2 | NA | HAS2 Entrez, Source | hyaluronan synthase 2 | 1487 | 1.986 | 0.2021 | No |
| 18 | WISP1 | NA | WISP1 Entrez, Source | WNT1 inducible signaling pathway protein 1 | 1568 | 1.941 | 0.2098 | No |
| 19 | SPP1 | NA | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 1647 | 1.897 | 0.2174 | No |
| 20 | MMP15 | NA | MMP15 Entrez, Source | matrix metallopeptidase 15 (membrane-inserted) | 1663 | 1.892 | 0.2273 | No |
| 21 | CHST2 | NA | CHST2 Entrez, Source | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 1693 | 1.877 | 0.2366 | No |
| 22 | AGRN | NA | 1912 | 1.773 | 0.2383 | No | ||
| 23 | CA12 | NA | CA12 Entrez, Source | carbonic anhydrase XII | 2034 | 1.706 | 0.2433 | No |
| 24 | ADAM19 | NA | ADAM19 Entrez, Source | ADAM metallopeptidase domain 19 (meltrin beta) | 2593 | 1.464 | 0.2309 | No |
| 25 | CHST11 | NA | CHST11 Entrez, Source | carbohydrate (chondroitin 4) sulfotransferase 11 | 2709 | 1.419 | 0.2345 | No |
| 26 | COL7A1 | NA | COL7A1 Entrez, Source | collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) | 2844 | 1.369 | 0.2371 | No |
| 27 | MT1F | NA | MT1F Entrez, Source | metallothionein 1F (functional) | 3192 | 1.243 | 0.2312 | No |
| 28 | ITGA5 | NA | ITGA5 Entrez, Source | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 3226 | 1.233 | 0.2368 | No |
| 29 | SRPX2 | NA | SRPX2 Entrez, Source | sushi-repeat-containing protein, X-linked 2 | 3318 | 1.208 | 0.2401 | No |
| 30 | TGFBR3 | NA | TGFBR3 Entrez, Source | transforming growth factor, beta receptor III (betaglycan, 300kDa) | 3477 | 1.162 | 0.2407 | No |
| 31 | PLXNA1 | NA | PLXNA1 Entrez, Source | plexin A1 | 3556 | 1.135 | 0.2441 | No |
| 32 | PAPPA | NA | PAPPA Entrez, Source | pregnancy-associated plasma protein A, pappalysin 1 | 3627 | 1.107 | 0.2476 | No |
| 33 | KCNJ15 | NA | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 3713 | 1.079 | 0.2504 | No |
| 34 | STX1A | NA | STX1A Entrez, Source | syntaxin 1A (brain) | 3789 | 1.055 | 0.2535 | No |
| 35 | EDN1 | NA | EDN1 Entrez, Source | endothelin 1 | 3804 | 1.049 | 0.2587 | No |
| 36 | TYRO3 | NA | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 3976 | 0.992 | 0.2579 | No |
| 37 | FAP | NA | FAP Entrez, Source | fibroblast activation protein, alpha | 4373 | 0.889 | 0.2483 | No |
| 38 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 4383 | 0.886 | 0.2528 | No |
| 39 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4414 | 0.880 | 0.2566 | No |
| 40 | HBEGF | NA | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 4667 | 0.821 | 0.2518 | No |
| 41 | SLCO2A1 | NA | SLCO2A1 Entrez, Source | solute carrier organic anion transporter family, member 2A1 | 5343 | 0.651 | 0.2306 | No |
| 42 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 5666 | 0.584 | 0.2220 | No |
| 43 | KIF21B | NA | KIF21B Entrez, Source | kinesin family member 21B | 5753 | 0.569 | 0.2219 | No |
| 44 | ABCC5 | NA | ABCC5 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5820 | 0.558 | 0.2226 | No |
| 45 | ECM1 | NA | ECM1 Entrez, Source | extracellular matrix protein 1 | 5933 | 0.540 | 0.2215 | No |
| 46 | C7orf54 | NA | 6045 | 0.519 | 0.2202 | No | ||
| 47 | PYGB | NA | PYGB Entrez, Source | phosphorylase, glycogen; brain | 6227 | 0.493 | 0.2163 | No |
| 48 | ARL4C | NA | ARL4C Entrez, Source | ADP-ribosylation factor-like 4C | 6533 | 0.448 | 0.2075 | No |
| 49 | TEK | NA | TEK Entrez, Source | TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) | 6705 | 0.428 | 0.2036 | No |
| 50 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 6780 | 0.420 | 0.2032 | No |
| 51 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 6852 | 0.412 | 0.2029 | No |
| 52 | C3orf52 | NA | C3ORF52 Entrez, Source | chromosome 3 open reading frame 52 | 7180 | 0.377 | 0.1929 | No |
| 53 | MLL | NA | MLL Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 7425 | 0.351 | 0.1859 | No |
| 54 | CRISPLD2 | NA | CRISPLD2 Entrez, Source | cysteine-rich secretory protein LCCL domain containing 2 | 7821 | 0.316 | 0.1731 | No |
| 55 | SLC2A6 | NA | SLC2A6 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 6 | 8458 | 0.265 | 0.1512 | No |
| 56 | KCNN3 | NA | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 9086 | 0.225 | 0.1294 | No |
| 57 | SLC1A4 | NA | SLC1A4 Entrez, Source | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 9440 | 0.206 | 0.1175 | No |
| 58 | CPA4 | NA | CPA4 Entrez, Source | carboxypeptidase A4 | 10050 | 0.176 | 0.0961 | No |
| 59 | SLC6A9 | NA | SLC6A9 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 11257 | 0.120 | 0.0524 | No |
| 60 | LTBP4 | NA | LTBP4 Entrez, Source | latent transforming growth factor beta binding protein 4 | 11330 | 0.116 | 0.0504 | No |
| 61 | ADAM12 | NA | ADAM12 Entrez, Source | ADAM metallopeptidase domain 12 (meltrin alpha) | 11530 | 0.109 | 0.0437 | No |
| 62 | CLSPN | NA | CLSPN Entrez, Source | claspin homolog (Xenopus laevis) | 11664 | 0.103 | 0.0394 | No |
| 63 | LCP1 | NA | LCP1 Entrez, Source | lymphocyte cytosolic protein 1 (L-plastin) | 11683 | 0.103 | 0.0393 | No |
| 64 | INHBA | NA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 11814 | 0.097 | 0.0350 | No |
| 65 | DDIT4 | NA | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 13010 | 0.053 | -0.0086 | No |
| 66 | C2CD2L | NA | 13542 | 0.032 | -0.0280 | No | ||
| 67 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 13873 | 0.019 | -0.0400 | No |
| 68 | GNB3 | NA | GNB3 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 3 | 14253 | 0.006 | -0.0539 | No |
| 69 | GDF5 | NA | GDF5 Entrez, Source | growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) | 14866 | -0.016 | -0.0764 | No |
| 70 | GAL | NA | GAL Entrez, Source | galanin | 15232 | -0.030 | -0.0896 | No |
| 71 | FGF21 | NA | FGF21 Entrez, Source | fibroblast growth factor 21 | 15291 | -0.033 | -0.0916 | No |
| 72 | MEOX1 | NA | MEOX1 Entrez, Source | mesenchyme homeobox 1 | 15937 | -0.057 | -0.1150 | No |
| 73 | CSF2 | NA | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 16165 | -0.067 | -0.1229 | No |
| 74 | SLC7A11 | NA | SLC7A11 Entrez, Source | solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 | 17180 | -0.109 | -0.1596 | No |
| 75 | TFEC | NA | TFEC Entrez, Source | transcription factor EC | 17495 | -0.124 | -0.1705 | No |
| 76 | EPHA2 | NA | EPHA2 Entrez, Source | EPH receptor A2 | 17523 | -0.125 | -0.1708 | No |
| 77 | MMP7 | NA | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 17530 | -0.126 | -0.1703 | No |
| 78 | PMEPA1 | NA | 17548 | -0.126 | -0.1703 | No | ||
| 79 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 17747 | -0.137 | -0.1768 | No |
| 80 | TIE1 | NA | TIE1 Entrez, Source | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 17892 | -0.147 | -0.1813 | No |
| 81 | GREM1 | NA | GREM1 Entrez, Source | gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) | 18865 | -0.215 | -0.2158 | No |
| 82 | NTM | NA | 19833 | -0.303 | -0.2497 | No | ||
| 83 | TNFRSF8 | NA | TNFRSF8 Entrez, Source | tumor necrosis factor receptor superfamily, member 8 | 19904 | -0.310 | -0.2506 | No |
| 84 | FZD6 | NA | FZD6 Entrez, Source | frizzled homolog 6 (Drosophila) | 19907 | -0.310 | -0.2489 | No |
| 85 | GPR3 | NA | GPR3 Entrez, Source | G protein-coupled receptor 3 | 20303 | -0.356 | -0.2615 | No |
| 86 | TNFRSF9 | NA | TNFRSF9 Entrez, Source | tumor necrosis factor receptor superfamily, member 9 | 21018 | -0.456 | -0.2853 | No |
| 87 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 21108 | -0.469 | -0.2859 | No |
| 88 | PDCD1LG2 | NA | PDCD1LG2 Entrez, Source | programmed cell death 1 ligand 2 | 21180 | -0.478 | -0.2859 | No |
| 89 | STC2 | NA | STC2 Entrez, Source | stanniocalcin 2 | 21227 | -0.485 | -0.2849 | No |
| 90 | VLDLR | NA | VLDLR Entrez, Source | very low density lipoprotein receptor | 21561 | -0.545 | -0.2942 | No |
| 91 | DDX11 | NA | DDX11 Entrez, Source | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) | 21615 | -0.554 | -0.2931 | No |
| 92 | LHFPL2 | NA | LHFPL2 Entrez, Source | lipoma HMGIC fusion partner-like 2 | 22154 | -0.657 | -0.3092 | No |
| 93 | NT5E | NA | NT5E Entrez, Source | 5'-nucleotidase, ecto (CD73) | 22231 | -0.672 | -0.3083 | No |
| 94 | SLC19A1 | NA | SLC19A1 Entrez, Source | solute carrier family 19 (folate transporter), member 1 | 22643 | -0.763 | -0.3192 | No |
| 95 | CD83 | NA | CD83 Entrez, Source | CD83 molecule | 22644 | -0.763 | -0.3150 | No |
| 96 | VNN1 | NA | VNN1 Entrez, Source | vanin 1 | 23043 | -0.847 | -0.3250 | No |
| 97 | CDH13 | NA | CDH13 Entrez, Source | cadherin 13, H-cadherin (heart) | 23118 | -0.862 | -0.3230 | No |
| 98 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 23140 | -0.867 | -0.3190 | No |
| 99 | FURIN | NA | FURIN Entrez, Source | furin (paired basic amino acid cleaving enzyme) | 23215 | -0.883 | -0.3168 | No |
| 100 | ERO1L | NA | ERO1L Entrez, Source | ERO1-like (S. cerevisiae) | 23287 | -0.898 | -0.3145 | No |
| 101 | ENTPD6 | NA | ENTPD6 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 6 (putative function) | 23477 | -0.945 | -0.3162 | No |
| 102 | NRP2 | NA | NRP2 Entrez, Source | neuropilin 2 | 23738 | -1.017 | -0.3202 | No |
| 103 | ZC3H12A | NA | ZC3H12A Entrez, Source | zinc finger CCCH-type containing 12A | 24130 | -1.129 | -0.3283 | Yes |
| 104 | COL13A1 | NA | COL13A1 Entrez, Source | collagen, type XIII, alpha 1 | 24159 | -1.138 | -0.3231 | Yes |
| 105 | WNT5B | NA | WNT5B Entrez, Source | wingless-type MMTV integration site family, member 5B | 24194 | -1.147 | -0.3180 | Yes |
| 106 | LAMB3 | NA | LAMB3 Entrez, Source | laminin, beta 3 | 24588 | -1.273 | -0.3254 | Yes |
| 107 | INHBE | NA | INHBE Entrez, Source | inhibin, beta E | 24647 | -1.293 | -0.3204 | Yes |
| 108 | SLC16A6 | NA | SLC16A6 Entrez, Source | solute carrier family 16, member 6 (monocarboxylic acid transporter 7) | 24660 | -1.296 | -0.3137 | Yes |
| 109 | SLC29A1 | NA | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 24888 | -1.374 | -0.3145 | Yes |
| 110 | ASPH | NA | ASPH Entrez, Source | aspartate beta-hydroxylase | 24917 | -1.385 | -0.3079 | Yes |
| 111 | STEAP3 | NA | STEAP3 Entrez, Source | STEAP family member 3 | 24918 | -1.386 | -0.3002 | Yes |
| 112 | ATP13A2 | NA | ATP13A2 Entrez, Source | ATPase type 13A2 | 25190 | -1.497 | -0.3020 | Yes |
| 113 | SLC22A4 | NA | SLC22A4 Entrez, Source | solute carrier family 22 (organic cation transporter), member 4 | 25340 | -1.566 | -0.2988 | Yes |
| 114 | SIK1 | NA | 25391 | -1.588 | -0.2919 | Yes | ||
| 115 | C2CD2 | NA | 25445 | -1.616 | -0.2849 | Yes | ||
| 116 | FADS3 | NA | FADS3 Entrez, Source | fatty acid desaturase 3 | 25715 | -1.747 | -0.2852 | Yes |
| 117 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 25740 | -1.759 | -0.2764 | Yes |
| 118 | CXCL1 | NA | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 25823 | -1.806 | -0.2694 | Yes |
| 119 | SLCO4A1 | NA | SLCO4A1 Entrez, Source | solute carrier organic anion transporter family, member 4A1 | 25930 | -1.874 | -0.2630 | Yes |
| 120 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 25962 | -1.892 | -0.2537 | Yes |
| 121 | TNFSF9 | NA | TNFSF9 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 9 | 26008 | -1.921 | -0.2448 | Yes |
| 122 | ABLIM3 | NA | ABLIM3 Entrez, Source | actin binding LIM protein family, member 3 | 26041 | -1.944 | -0.2352 | Yes |
| 123 | LIF | NA | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 26070 | -1.959 | -0.2254 | Yes |
| 124 | CLDN1 | NA | CLDN1 Entrez, Source | claudin 1 | 26211 | -2.067 | -0.2192 | Yes |
| 125 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 26352 | -2.173 | -0.2124 | Yes |
| 126 | FOSL1 | NA | FOSL1 Entrez, Source | FOS-like antigen 1 | 26452 | -2.259 | -0.2035 | Yes |
| 127 | MICB | NA | MICB Entrez, Source | MHC class I polypeptide-related sequence B | 26520 | -2.314 | -0.1932 | Yes |
| 128 | ITGA3 | NA | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 26624 | -2.410 | -0.1837 | Yes |
| 129 | PTHLH | NA | PTHLH Entrez, Source | parathyroid hormone-like hormone | 26693 | -2.489 | -0.1725 | Yes |
| 130 | MICA | NA | MICA Entrez, Source | MHC class I polypeptide-related sequence A | 26889 | -2.797 | -0.1643 | Yes |
| 131 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 26913 | -2.831 | -0.1495 | Yes |
| 132 | SLC7A5 | NA | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 26946 | -2.902 | -0.1347 | Yes |
| 133 | P2RX5 | NA | P2RX5 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 5 | 27031 | -3.135 | -0.1205 | Yes |
| 134 | SLC1A5 | NA | SLC1A5 Entrez, Source | solute carrier family 1 (neutral amino acid transporter), member 5 | 27061 | -3.213 | -0.1038 | Yes |
| 135 | GFPT2 | NA | GFPT2 Entrez, Source | glutamine-fructose-6-phosphate transaminase 2 | 27142 | -3.513 | -0.0874 | Yes |
| 136 | ITPR3 | NA | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 27213 | -3.878 | -0.0686 | Yes |
| 137 | HS3ST3A1 | NA | HS3ST3A1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 27265 | -4.264 | -0.0469 | Yes |
| 138 | VEGFC | NA | VEGFC Entrez, Source | vascular endothelial growth factor C | 27284 | -4.454 | -0.0230 | Yes |
| 139 | CDCP1 | NA | CDCP1 Entrez, Source | CUB domain containing protein 1 | 27286 | -4.471 | 0.0016 | Yes |
