Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | NRL_DN.V1_DN |
| Enrichment Score (ES) | 0.38181317 |
| Normalized Enrichment Score (NES) | 1.4905564 |
| Nominal p-value | 0.0020283975 |
| FDR q-value | 0.036472324 |
| FWER p-Value | 0.284 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HES5 | NA | HES5 Entrez, Source | hairy and enhancer of split 5 (Drosophila) | 7 | 4.026 | 0.0307 | Yes |
| 2 | IL17D | NA | IL17D Entrez, Source | interleukin 17D | 127 | 3.407 | 0.0525 | Yes |
| 3 | FABP7 | NA | FABP7 Entrez, Source | fatty acid binding protein 7, brain | 323 | 3.044 | 0.0687 | Yes |
| 4 | SLC8A3 | NA | SLC8A3 Entrez, Source | solute carrier family 8 (sodium-calcium exchanger), member 3 | 512 | 2.781 | 0.0831 | Yes |
| 5 | PLEKHH2 | NA | PLEKHH2 Entrez, Source | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | 626 | 2.649 | 0.0993 | Yes |
| 6 | GTF2I | NA | GTF2I Entrez, Source | general transcription factor II, i | 689 | 2.587 | 0.1169 | Yes |
| 7 | JAM3 | NA | JAM3 Entrez, Source | junctional adhesion molecule 3 | 696 | 2.580 | 0.1365 | Yes |
| 8 | TNPO2 | NA | TNPO2 Entrez, Source | transportin 2 (importin 3, karyopherin beta 2b) | 729 | 2.544 | 0.1549 | Yes |
| 9 | FKBP9 | NA | FKBP9 Entrez, Source | FK506 binding protein 9, 63 kDa | 803 | 2.467 | 0.1711 | Yes |
| 10 | KIF5C | NA | KIF5C Entrez, Source | kinesin family member 5C | 1092 | 2.248 | 0.1778 | Yes |
| 11 | METRN | NA | METRN Entrez, Source | meteorin, glial cell differentiation regulator | 1370 | 2.059 | 0.1835 | Yes |
| 12 | BST2 | NA | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 1430 | 2.017 | 0.1968 | Yes |
| 13 | DPP8 | NA | DPP8 Entrez, Source | dipeptidyl-peptidase 8 | 1481 | 1.989 | 0.2102 | Yes |
| 14 | C14orf132 | NA | C14ORF132 Entrez, Source | chromosome 14 open reading frame 132 | 1582 | 1.932 | 0.2214 | Yes |
| 15 | BAX | NA | BAX Entrez, Source | BCL2-associated X protein | 1823 | 1.810 | 0.2265 | Yes |
| 16 | PTPN13 | NA | PTPN13 Entrez, Source | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 1829 | 1.809 | 0.2402 | Yes |
| 17 | GGT7 | NA | 1866 | 1.795 | 0.2526 | Yes | ||
| 18 | U2AF1 | NA | U2AF1 Entrez, Source | U2 small nuclear RNA auxiliary factor 1 | 2078 | 1.686 | 0.2578 | Yes |
| 19 | MAP6 | NA | MAP6 Entrez, Source | microtubule-associated protein 6 | 2263 | 1.611 | 0.2634 | Yes |
| 20 | PDE1C | NA | PDE1C Entrez, Source | phosphodiesterase 1C, calmodulin-dependent 70kDa | 2286 | 1.601 | 0.2749 | Yes |
| 21 | DIXDC1 | NA | DIXDC1 Entrez, Source | DIX domain containing 1 | 2325 | 1.585 | 0.2857 | Yes |
| 22 | HRASLS | NA | HRASLS Entrez, Source | HRAS-like suppressor | 2473 | 1.516 | 0.2919 | Yes |
| 23 | ERMAP | NA | ERMAP Entrez, Source | erythroblast membrane-associated protein (Scianna blood group) | 2623 | 1.451 | 0.2976 | Yes |
| 24 | ABHD3 | NA | ABHD3 Entrez, Source | abhydrolase domain containing 3 | 2672 | 1.436 | 0.3069 | Yes |
| 25 | ELOVL2 | NA | ELOVL2 Entrez, Source | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 | 2759 | 1.396 | 0.3144 | Yes |
| 26 | EN2 | NA | EN2 Entrez, Source | engrailed homolog 2 | 2939 | 1.334 | 0.3181 | Yes |
| 27 | GPR124 | NA | GPR124 Entrez, Source | G protein-coupled receptor 124 | 3080 | 1.284 | 0.3228 | Yes |
| 28 | INPPL1 | NA | INPPL1 Entrez, Source | inositol polyphosphate phosphatase-like 1 | 3212 | 1.236 | 0.3275 | Yes |
| 29 | ST3GAL3 | NA | ST3GAL3 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | 3237 | 1.230 | 0.3360 | Yes |
| 30 | RAB8A | NA | RAB8A Entrez, Source | RAB8A, member RAS oncogene family | 3450 | 1.168 | 0.3372 | Yes |
| 31 | TTLL1 | NA | TTLL1 Entrez, Source | tubulin tyrosine ligase-like family, member 1 | 3532 | 1.144 | 0.3430 | Yes |
| 32 | ECE1 | NA | ECE1 Entrez, Source | endothelin converting enzyme 1 | 3542 | 1.140 | 0.3515 | Yes |
| 33 | FAM134C | NA | 3571 | 1.130 | 0.3591 | Yes | ||
| 34 | WDR31 | NA | WDR31 Entrez, Source | WD repeat domain 31 | 3700 | 1.083 | 0.3627 | Yes |
| 35 | GREB1 | NA | GREB1 Entrez, Source | - | 3762 | 1.065 | 0.3687 | Yes |
| 36 | SLC7A3 | NA | SLC7A3 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 | 3896 | 1.020 | 0.3716 | Yes |
| 37 | MOGAT1 | NA | MOGAT1 Entrez, Source | monoacylglycerol O-acyltransferase 1 | 3991 | 0.989 | 0.3757 | Yes |
| 38 | DFNA5 | NA | DFNA5 Entrez, Source | deafness, autosomal dominant 5 | 4198 | 0.932 | 0.3753 | Yes |
| 39 | DNAJC9 | NA | DNAJC9 Entrez, Source | DnaJ (Hsp40) homolog, subfamily C, member 9 | 4606 | 0.841 | 0.3668 | Yes |
| 40 | MFNG | NA | MFNG Entrez, Source | manic fringe homolog (Drosophila) | 4627 | 0.832 | 0.3725 | Yes |
| 41 | SLC25A13 | NA | SLC25A13 Entrez, Source | solute carrier family 25, member 13 (citrin) | 4657 | 0.824 | 0.3778 | Yes |
| 42 | SALL3 | NA | SALL3 Entrez, Source | sal-like 3 (Drosophila) | 4716 | 0.806 | 0.3818 | Yes |
| 43 | TOM1L2 | NA | TOM1L2 Entrez, Source | target of myb1-like 2 (chicken) | 5306 | 0.660 | 0.3652 | No |
| 44 | NOXO1 | NA | NOXO1 Entrez, Source | NADPH oxidase organizer 1 | 5540 | 0.609 | 0.3613 | No |
| 45 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 5619 | 0.594 | 0.3630 | No |
| 46 | BMP5 | NA | BMP5 Entrez, Source | bone morphogenetic protein 5 | 6101 | 0.511 | 0.3493 | No |
| 47 | RNF25 | NA | RNF25 Entrez, Source | ring finger protein 25 | 6574 | 0.444 | 0.3353 | No |
| 48 | PRMT1 | NA | PRMT1 Entrez, Source | protein arginine methyltransferase 1 | 6833 | 0.415 | 0.3290 | No |
| 49 | D4S234E | NA | D4S234E Entrez, Source | - | 6856 | 0.412 | 0.3314 | No |
| 50 | MYOCD | NA | MYOCD Entrez, Source | myocardin | 7014 | 0.396 | 0.3287 | No |
| 51 | RNASE4 | NA | RNASE4 Entrez, Source | ribonuclease, RNase A family, 4 | 7871 | 0.311 | 0.2996 | No |
| 52 | TMED9 | NA | TMED9 Entrez, Source | transmembrane emp24 protein transport domain containing 9 | 8464 | 0.265 | 0.2799 | No |
| 53 | PIK3AP1 | NA | PIK3AP1 Entrez, Source | phosphoinositide-3-kinase adaptor protein 1 | 8507 | 0.263 | 0.2803 | No |
| 54 | BMP15 | NA | BMP15 Entrez, Source | bone morphogenetic protein 15 | 8682 | 0.250 | 0.2759 | No |
| 55 | C11orf52 | NA | C11ORF52 Entrez, Source | chromosome 11 open reading frame 52 | 8718 | 0.247 | 0.2765 | No |
| 56 | ABCC9 | NA | ABCC9 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 8766 | 0.243 | 0.2766 | No |
| 57 | SMPDL3A | NA | SMPDL3A Entrez, Source | sphingomyelin phosphodiesterase, acid-like 3A | 8919 | 0.234 | 0.2728 | No |
| 58 | ARPC3 | NA | ARPC3 Entrez, Source | actin related protein 2/3 complex, subunit 3, 21kDa | 8966 | 0.232 | 0.2729 | No |
| 59 | CCKBR | NA | CCKBR Entrez, Source | cholecystokinin B receptor | 9421 | 0.207 | 0.2578 | No |
| 60 | TC2N | NA | 9627 | 0.196 | 0.2518 | No | ||
| 61 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 9704 | 0.193 | 0.2505 | No |
| 62 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 10099 | 0.174 | 0.2373 | No |
| 63 | CNGB3 | NA | CNGB3 Entrez, Source | cyclic nucleotide gated channel beta 3 | 10413 | 0.160 | 0.2271 | No |
| 64 | PARVG | NA | PARVG Entrez, Source | parvin, gamma | 10535 | 0.154 | 0.2238 | No |
| 65 | BSPRY | NA | BSPRY Entrez, Source | B-box and SPRY domain containing | 10565 | 0.153 | 0.2239 | No |
| 66 | CPLX2 | NA | CPLX2 Entrez, Source | complexin 2 | 10726 | 0.145 | 0.2191 | No |
| 67 | ABCB4 | NA | ABCB4 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 10750 | 0.144 | 0.2194 | No |
| 68 | ATP2A1 | NA | ATP2A1 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 11689 | 0.102 | 0.1857 | No |
| 69 | GABRA2 | NA | GABRA2 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 12036 | 0.089 | 0.1736 | No |
| 70 | EYA1 | NA | EYA1 Entrez, Source | eyes absent homolog 1 (Drosophila) | 12135 | 0.085 | 0.1707 | No |
| 71 | TRIM17 | NA | TRIM17 Entrez, Source | tripartite motif-containing 17 | 13061 | 0.051 | 0.1371 | No |
| 72 | SLAMF9 | NA | SLAMF9 Entrez, Source | SLAM family member 9 | 13273 | 0.042 | 0.1297 | No |
| 73 | RASGRF2 | NA | RASGRF2 Entrez, Source | Ras protein-specific guanine nucleotide-releasing factor 2 | 14023 | 0.014 | 0.1022 | No |
| 74 | SUPT16H | NA | SUPT16H Entrez, Source | suppressor of Ty 16 homolog (S. cerevisiae) | 14514 | -0.003 | 0.0842 | No |
| 75 | DPRX | NA | DPRX Entrez, Source | divergent-paired related homeobox | 14549 | -0.004 | 0.0830 | No |
| 76 | GLRA3 | NA | GLRA3 Entrez, Source | glycine receptor, alpha 3 | 14944 | -0.019 | 0.0687 | No |
| 77 | CALCA | NA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 15001 | -0.021 | 0.0668 | No |
| 78 | TSPAN33 | NA | TSPAN33 Entrez, Source | tetraspanin 33 | 15029 | -0.022 | 0.0660 | No |
| 79 | AP2B1 | NA | AP2B1 Entrez, Source | adaptor-related protein complex 2, beta 1 subunit | 15912 | -0.056 | 0.0340 | No |
| 80 | PDIA3 | NA | PDIA3 Entrez, Source | protein disulfide isomerase family A, member 3 | 16486 | -0.080 | 0.0135 | No |
| 81 | GJD2 | NA | 16754 | -0.091 | 0.0044 | No | ||
| 82 | DYNC1LI1 | NA | DYNC1LI1 Entrez, Source | dynein, cytoplasmic 1, light intermediate chain 1 | 17511 | -0.125 | -0.0224 | No |
| 83 | GLRA1 | NA | GLRA1 Entrez, Source | glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) | 17569 | -0.128 | -0.0235 | No |
| 84 | DYSF | NA | DYSF Entrez, Source | dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) | 18409 | -0.179 | -0.0530 | No |
| 85 | GZMM | NA | GZMM Entrez, Source | granzyme M (lymphocyte met-ase 1) | 18821 | -0.212 | -0.0665 | No |
| 86 | LMNB2 | NA | LMNB2 Entrez, Source | lamin B2 | 19005 | -0.227 | -0.0715 | No |
| 87 | USP25 | NA | USP25 Entrez, Source | ubiquitin specific peptidase 25 | 19091 | -0.234 | -0.0728 | No |
| 88 | ZNF316 | NA | ZNF316 Entrez, Source | zinc finger protein 316 | 19119 | -0.237 | -0.0720 | No |
| 89 | ORAI1 | NA | 19195 | -0.244 | -0.0729 | No | ||
| 90 | BBX | NA | BBX Entrez, Source | bobby sox homolog (Drosophila) | 19336 | -0.254 | -0.0761 | No |
| 91 | CDT1 | NA | CDT1 Entrez, Source | chromatin licensing and DNA replication factor 1 | 19361 | -0.256 | -0.0750 | No |
| 92 | ZNF146 | NA | ZNF146 Entrez, Source | zinc finger protein 146 | 19505 | -0.270 | -0.0782 | No |
| 93 | CLIC4 | NA | CLIC4 Entrez, Source | chloride intracellular channel 4 | 19546 | -0.275 | -0.0775 | No |
| 94 | PRDM1 | NA | PRDM1 Entrez, Source | PR domain containing 1, with ZNF domain | 20217 | -0.343 | -0.0995 | No |
| 95 | CLCA3P | NA | 20274 | -0.352 | -0.0989 | No | ||
| 96 | CRYBG3 | NA | 20471 | -0.377 | -0.1032 | No | ||
| 97 | NR4A1 | NA | NR4A1 Entrez, Source | nuclear receptor subfamily 4, group A, member 1 | 20585 | -0.391 | -0.1043 | No |
| 98 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 20994 | -0.451 | -0.1159 | No |
| 99 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 21067 | -0.462 | -0.1150 | No |
| 100 | ATOH7 | NA | ATOH7 Entrez, Source | atonal homolog 7 (Drosophila) | 21128 | -0.472 | -0.1135 | No |
| 101 | CASP7 | NA | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 21218 | -0.483 | -0.1131 | No |
| 102 | RGS20 | NA | RGS20 Entrez, Source | regulator of G-protein signalling 20 | 21414 | -0.518 | -0.1163 | No |
| 103 | RASA2 | NA | RASA2 Entrez, Source | RAS p21 protein activator 2 | 21520 | -0.538 | -0.1160 | No |
| 104 | ACBD6 | NA | ACBD6 Entrez, Source | acyl-Coenzyme A binding domain containing 6 | 21534 | -0.540 | -0.1124 | No |
| 105 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 21956 | -0.621 | -0.1231 | No |
| 106 | CLIC1 | NA | CLIC1 Entrez, Source | chloride intracellular channel 1 | 22393 | -0.706 | -0.1337 | No |
| 107 | C19orf39 | NA | C19ORF39 Entrez, Source | chromosome 19 open reading frame 39 | 22475 | -0.723 | -0.1311 | No |
| 108 | ATE1 | NA | ATE1 Entrez, Source | arginyltransferase 1 | 22915 | -0.822 | -0.1409 | No |
| 109 | CTBS | NA | CTBS Entrez, Source | chitobiase, di-N-acetyl- | 23125 | -0.863 | -0.1420 | No |
| 110 | CTH | NA | CTH Entrez, Source | cystathionase (cystathionine gamma-lyase) | 23517 | -0.956 | -0.1490 | No |
| 111 | PRKCQ | NA | PRKCQ Entrez, Source | protein kinase C, theta | 23978 | -1.082 | -0.1576 | No |
| 112 | TRAPPC3 | NA | TRAPPC3 Entrez, Source | trafficking protein particle complex 3 | 24297 | -1.178 | -0.1602 | No |
| 113 | ARHGDIB | NA | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 24415 | -1.214 | -0.1552 | No |
| 114 | RGL3 | NA | RGL3 Entrez, Source | ral guanine nucleotide dissociation stimulator-like 3 | 24562 | -1.267 | -0.1509 | No |
| 115 | MPP6 | NA | MPP6 Entrez, Source | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 24804 | -1.345 | -0.1494 | No |
| 116 | ELK3 | NA | ELK3 Entrez, Source | ELK3, ETS-domain protein (SRF accessory protein 2) | 25026 | -1.430 | -0.1465 | No |
| 117 | EPM2AIP1 | NA | EPM2AIP1 Entrez, Source | EPM2A (laforin) interacting protein 1 | 25207 | -1.505 | -0.1416 | No |
| 118 | CLPB | NA | CLPB Entrez, Source | ClpB caseinolytic peptidase B homolog (E. coli) | 25852 | -1.827 | -0.1512 | No |
| 119 | QSOX1 | NA | 26171 | -2.043 | -0.1472 | No | ||
| 120 | RNF149 | NA | RNF149 Entrez, Source | ring finger protein 149 | 26232 | -2.076 | -0.1335 | No |
| 121 | HARS2 | NA | HARS2 Entrez, Source | histidyl-tRNA synthetase 2 | 26331 | -2.153 | -0.1205 | No |
| 122 | TMEM158 | NA | TMEM158 Entrez, Source | transmembrane protein 158 | 26610 | -2.396 | -0.1124 | No |
| 123 | MOXD1 | NA | MOXD1 Entrez, Source | monooxygenase, DBH-like 1 | 26683 | -2.480 | -0.0960 | No |
| 124 | ADRB1 | NA | ADRB1 Entrez, Source | adrenergic, beta-1-, receptor | 26938 | -2.889 | -0.0831 | No |
| 125 | WWC1 | NA | WWC1 Entrez, Source | WW, C2 and coiled-coil domain containing 1 | 26975 | -2.960 | -0.0617 | No |
| 126 | MINA | NA | MINA Entrez, Source | MYC induced nuclear antigen | 27005 | -3.051 | -0.0393 | No |
| 127 | TUFT1 | NA | TUFT1 Entrez, Source | tuftelin 1 | 27042 | -3.161 | -0.0164 | No |
| 128 | ADRB2 | NA | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 27138 | -3.500 | 0.0070 | No |
