Datasetexpression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls
#wt_versus_radiation.mainSample.cls
#wt_versus_radiation_repos
PhenotypemainSample.cls#wt_versus_radiation_repos
Upregulated in class2
GeneSetPDGF_ERK_DN.V1_UP
Enrichment Score (ES)-0.29501608
Normalized Enrichment Score (NES)-1.2530729
Nominal p-value0.08050848
FDR q-value0.2124344
FWER p-Value0.845
Table: GSEA Results Summary



Fig 1: Enrichment plot: PDGF_ERK_DN.V1_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1PMP22NAPMP22
Entrez,  Source
peripheral myelin protein 22413.7130.0261No
2MAP2NAMAP2
Entrez,  Source
microtubule-associated protein 2543.6430.0527No
3TSPAN5NATSPAN5
Entrez,  Source
tetraspanin 5653.5910.0789No
4SOX21NASOX21
Entrez,  Source
SRY (sex determining region Y)-box 211893.2870.0988No
5CORO2BNACORO2B
Entrez,  Source
coronin, actin binding protein, 2B4732.8360.1095No
6CDK6NACDK6
Entrez,  Source
cyclin-dependent kinase 67742.4960.1170No
7CFDP1NACFDP1
Entrez,  Source
craniofacial development protein 19122.3810.1296No
8ZIC4NAZIC4
Entrez,  Source
Zic family member 410732.2610.1405No
9NRIP1NANRIP1
Entrez,  Source
nuclear receptor interacting protein 111652.1990.1535No
10STX12NASTX12
Entrez,  Source
syntaxin 1211932.1810.1687No
11SLC39A7NASLC39A7
Entrez,  Source
solute carrier family 39 (zinc transporter), member 717721.8390.1611No
12TSPAN9NATSPAN9
Entrez,  Source
tetraspanin 920551.6950.1633No
13NOS2NA24191.5390.1613No
14SWAP70NASWAP70
Entrez,  Source
-24371.5310.1721No
15PTGDSNAPTGDS
Entrez,  Source
prostaglandin D2 synthase 21kDa (brain)26691.4370.1742No
16ST6GAL1NAST6GAL1
Entrez,  Source
ST6 beta-galactosamide alpha-2,6-sialyltranferase 126901.4250.1841No
17GAP43NAGAP43
Entrez,  Source
growth associated protein 4327431.4030.1926No
18NRG1NANRG1
Entrez,  Source
neuregulin 131171.2710.1883No
19CPS1NACPS1
Entrez,  Source
carbamoyl-phosphate synthetase 1, mitochondrial32031.2380.1944No
20EXOSC8NAEXOSC8
Entrez,  Source
exosome component 834151.1790.1954No
21SERINC1NASERINC1
Entrez,  Source
serine incorporator 136391.1020.1953No
22ATXN2NAATXN2
Entrez,  Source
ataxin 238181.0440.1965No
23FAM149B1NA38501.0350.2031No
24SNX19NASNX19
Entrez,  Source
sorting nexin 1940220.9790.2041No
25ZNF84NAZNF84
Entrez,  Source
zinc finger protein 8440760.9650.2093No
26DDNNADDN
Entrez,  Source
dendrin41730.9400.2127No
27CLCN2NACLCN2
Entrez,  Source
chloride channel 244100.8810.2106No
28HDLBPNAHDLBP
Entrez,  Source
high density lipoprotein binding protein (vigilin)44470.8720.2157No
29ALDH5A1NAALDH5A1
Entrez,  Source
aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)47150.8060.2119No
30TP53I3NATP53I3
Entrez,  Source
tumor protein p53 inducible protein 351100.7180.2027No
31CCL25NACCL25
Entrez,  Source
chemokine (C-C motif) ligand 2552570.6750.2024No
32XPANAXPA
Entrez,  Source
xeroderma pigmentosum, complementation group A53270.6550.2047No
33COL1A1NACOL1A1
Entrez,  Source
collagen, type I, alpha 156210.5940.1983No
34PHLDA2NAPHLDA2
Entrez,  Source
pleckstrin homology-like domain, family A, member 257240.5750.1988No
35RESTNAREST
Entrez,  Source
RE1-silencing transcription factor59340.5400.1952No
36C7orf54NA60450.5190.1950No
37KBTBD11NAKBTBD11
Entrez,  Source
kelch repeat and BTB (POZ) domain containing 1162920.4820.1895No
38CETN2NACETN2
Entrez,  Source
centrin, EF-hand protein, 264410.4590.1875No
39ACP5NAACP5
Entrez,  Source
acid phosphatase 5, tartrate resistant65020.4530.1886No
40CDC14BNACDC14B
Entrez,  Source
CDC14 cell division cycle 14 homolog B (S. cerevisiae)65940.4410.1886No
41LEPROTNALEPROT
Entrez,  Source
leptin receptor overlapping transcript66150.4390.1911No
42GNMTNAGNMT
Entrez,  Source
glycine N-methyltransferase68780.4100.1845No
43MTHFRNAMTHFR
Entrez,  Source
5,10-methylenetetrahydrofolate reductase (NADPH)69440.4030.1851No
44MID1NAMID1
Entrez,  Source
midline 1 (Opitz/BBB syndrome)70280.3940.1850No
45HYAL1NAHYAL1
Entrez,  Source
hyaluronoglucosaminidase 173900.3550.1743No
46VPS39NAVPS39
Entrez,  Source
vacuolar protein sorting 39 (yeast)76650.3290.1667No
47COL10A1NACOL10A1
Entrez,  Source
collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)80070.3000.1564No
48C22orf31NAC22ORF31
Entrez,  Source
chromosome 22 open reading frame 3182420.2820.1499No
49THOC2NATHOC2
Entrez,  Source
THO complex 286330.2530.1374No
50TATNATAT
Entrez,  Source
tyrosine aminotransferase87410.2460.1353No
51TCEAL2NATCEAL2
Entrez,  Source
transcription elongation factor A (SII)-like 288030.2410.1348No
52ELP4NAELP4
Entrez,  Source
elongation protein 4 homolog (S. cerevisiae)92760.2150.1191No
53PKN2NAPKN2
Entrez,  Source
protein kinase N293540.2110.1178No
54FCHSD2NAFCHSD2
Entrez,  Source
FCH and double SH3 domains 297020.1930.1065No
55C4orf6NAC4ORF6
Entrez,  Source
chromosome 4 open reading frame 697660.1900.1056No
56TAF12NATAF12
Entrez,  Source
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa101680.1710.0921No
57NUP160NANUP160
Entrez,  Source
nucleoporin 160kDa104220.1590.0840No
58TNNT2NATNNT2
Entrez,  Source
troponin T type 2 (cardiac)107480.1440.0731No
59FSTL4NAFSTL4
Entrez,  Source
follistatin-like 4108880.1380.0690No
60KIR3DL2NAKIR3DL2
Entrez,  Source
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2112580.1200.0563No
61MAML3NAMAML3
Entrez,  Source
mastermind-like 3 (Drosophila)117860.0980.0377No
62INHBANAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)118140.0970.0374No
63TBX5NATBX5
Entrez,  Source
T-box 5118890.0940.0354No
64TRAF5NATRAF5
Entrez,  Source
TNF receptor-associated factor 5121900.0830.0250No
65HCRTR1NAHCRTR1
Entrez,  Source
hypocretin (orexin) receptor 1124230.0740.0170No
66NCKAP1LNANCKAP1L
Entrez,  Source
NCK-associated protein 1-like124380.0730.0170No
67SRYNASRY
Entrez,  Source
sex determining region Y124930.0710.0155No
68SERPINB2NASERPINB2
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 2125150.0700.0153No
69AQP3NAAQP3
Entrez,  Source
aquaporin 3 (Gill blood group)125390.0700.0150No
70IL12RB1NAIL12RB1
Entrez,  Source
interleukin 12 receptor, beta 1130250.052-0.0025No
71NMBRNANMBR
Entrez,  Source
neuromedin B receptor131170.048-0.0055No
72NBASNA132500.043-0.0100No
73GLRA2NAGLRA2
Entrez,  Source
glycine receptor, alpha 2136410.028-0.0241No
74NTNG1NANTNG1
Entrez,  Source
netrin G1140020.015-0.0373No
75OPRK1NAOPRK1
Entrez,  Source
opioid receptor, kappa 1140200.014-0.0378No
76OCA2NAOCA2
Entrez,  Source
oculocutaneous albinism II (pink-eye dilution homolog, mouse)141750.009-0.0434No
77NDUFS1NANDUFS1
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)142760.005-0.0470No
78MYBPC3NAMYBPC3
Entrez,  Source
myosin binding protein C, cardiac14931-0.018-0.0709No
79KLK7NAKLK7
Entrez,  Source
kallikrein 7 (chymotryptic, stratum corneum)15820-0.053-0.1032No
80PDIA3NAPDIA3
Entrez,  Source
protein disulfide isomerase family A, member 316486-0.080-0.1271No
81CLEC2BNACLEC2B
Entrez,  Source
C-type lectin domain family 2, member B16635-0.086-0.1319No
82LRCH4NALRCH4
Entrez,  Source
leucine-rich repeats and calponin homology (CH) domain containing 416978-0.100-0.1437No
83SNRPD3NASNRPD3
Entrez,  Source
small nuclear ribonucleoprotein D3 polypeptide 18kDa16999-0.101-0.1437No
84GALNT3NAGALNT3
Entrez,  Source
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)17392-0.119-0.1572No
85RALYLNA17456-0.122-0.1586No
86NDNNANDN
Entrez,  Source
necdin homolog (mouse)18838-0.212-0.2078No
87DSCR6NADSCR6
Entrez,  Source
Down syndrome critical region gene 618851-0.214-0.2067No
88LUZP2NALUZP2
Entrez,  Source
leucine zipper protein 218856-0.214-0.2053No
89DNAJC7NADNAJC7
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 719269-0.249-0.2186No
90PAN2NA19507-0.271-0.2253No
91OXCT1NAOXCT1
Entrez,  Source
3-oxoacid CoA transferase 120005-0.321-0.2412No
92MPINAMPI
Entrez,  Source
mannose phosphate isomerase20515-0.382-0.2570No
93MAGEA8NAMAGEA8
Entrez,  Source
melanoma antigen family A, 820635-0.397-0.2585No
94ANXA10NAANXA10
Entrez,  Source
annexin A1020884-0.436-0.2644No
95MRPS11NAMRPS11
Entrez,  Source
mitochondrial ribosomal protein S1121198-0.480-0.2723No
96MAOANAMAOA
Entrez,  Source
monoamine oxidase A21228-0.486-0.2698No
97AAGABNA21331-0.503-0.2698No
98RBM3NARBM3
Entrez,  Source
RNA binding motif (RNP1, RRM) protein 321476-0.529-0.2712No
99TTC18NATTC18
Entrez,  Source
tetratricopeptide repeat domain 1821719-0.574-0.2758No
100LMAN1NALMAN1
Entrez,  Source
lectin, mannose-binding, 121774-0.586-0.2734No
101SPAG5NASPAG5
Entrez,  Source
sperm associated antigen 521827-0.597-0.2709No
102FTSJD2NA22256-0.678-0.2816No
103NEU3NANEU3
Entrez,  Source
sialidase 3 (membrane sialidase)22517-0.733-0.2857No
104EXOSC10NAEXOSC10
Entrez,  Source
exosome component 1022527-0.735-0.2806No
105LOC81691NALOC81691
Entrez,  Source
-22650-0.765-0.2794No
106KIFAP3NAKIFAP3
Entrez,  Source
kinesin-associated protein 322852-0.807-0.2808No
107SNRNP40NA23089-0.856-0.2831No
108ATXN7NAATXN7
Entrez,  Source
ataxin 723413-0.929-0.2881Yes
109CALML4NACALML4
Entrez,  Source
calmodulin-like 423553-0.966-0.2861Yes
110AZI1NAAZI1
Entrez,  Source
5-azacytidine induced 123573-0.971-0.2795Yes
111RTCD1NARTCD1
Entrez,  Source
RNA terminal phosphate cyclase domain 123588-0.977-0.2728Yes
112RRBP1NARRBP1
Entrez,  Source
ribosome binding protein 1 homolog 180kDa (dog)23695-1.007-0.2692Yes
113ATF6NAATF6
Entrez,  Source
activating transcription factor 624198-1.147-0.2792Yes
114MYO1ENAMYO1E
Entrez,  Source
myosin IE24442-1.224-0.2790Yes
115LRPAP1NALRPAP1
Entrez,  Source
low density lipoprotein receptor-related protein associated protein 124477-1.235-0.2711Yes
116EXOSC7NAEXOSC7
Entrez,  Source
exosome component 724684-1.303-0.2690Yes
117RPIANARPIA
Entrez,  Source
ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase)24742-1.324-0.2613Yes
118ANXA7NAANXA7
Entrez,  Source
annexin A724823-1.351-0.2542Yes
119MVKNAMVK
Entrez,  Source
mevalonate kinase (mevalonic aciduria)24824-1.351-0.2442Yes
120ACOT11NAACOT11
Entrez,  Source
acyl-CoA thioesterase 1125249-1.521-0.2485Yes
121CREG1NACREG1
Entrez,  Source
cellular repressor of E1A-stimulated genes 125519-1.649-0.2461Yes
122GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)25564-1.671-0.2353Yes
123CHEK2NACHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)25612-1.694-0.2245Yes
124ADCY7NAADCY7
Entrez,  Source
adenylate cyclase 725733-1.754-0.2159Yes
125C17orf75NAC17ORF75
Entrez,  Source
chromosome 17 open reading frame 7526024-1.935-0.2122Yes
126HSPA4LNAHSPA4L
Entrez,  Source
heat shock 70kDa protein 4-like26273-2.108-0.2057Yes
127ANXA11NAANXA11
Entrez,  Source
annexin A1126366-2.184-0.1928Yes
128FLI1NAFLI1
Entrez,  Source
Friend leukemia virus integration 126467-2.267-0.1797Yes
129ZNF185NAZNF185
Entrez,  Source
zinc finger protein 185 (LIM domain)26572-2.357-0.1660Yes
130HEBP2NAHEBP2
Entrez,  Source
heme binding protein 226586-2.372-0.1489Yes
131TAF1BNATAF1B
Entrez,  Source
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa26594-2.379-0.1315Yes
132PSMB10NAPSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1026623-2.409-0.1146Yes
133RARSNARARS
Entrez,  Source
arginyl-tRNA synthetase26640-2.433-0.0972Yes
134PPICNAPPIC
Entrez,  Source
peptidylprolyl isomerase C (cyclophilin C)26687-2.486-0.0804Yes
135GTF2H5NAGTF2H5
Entrez,  Source
general transcription factor IIH, polypeptide 526979-2.976-0.0690Yes
136LAS1LNALAS1L
Entrez,  Source
LAS1-like (S. cerevisiae)27018-3.083-0.0475Yes
137PAX2NAPAX2
Entrez,  Source
paired box gene 227125-3.450-0.0258Yes
138NEK9NANEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 927289-4.4850.0015Yes
Table: GSEA details [plain text format]



Fig 2: PDGF_ERK_DN.V1_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: PDGF_ERK_DN.V1_UP: Random ES distribution   
Gene set null distribution of ES for PDGF_ERK_DN.V1_UP