Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | RB_P130_DN.V1_UP |
| Enrichment Score (ES) | -0.34681505 |
| Normalized Enrichment Score (NES) | -1.270773 |
| Nominal p-value | 0.044624746 |
| FDR q-value | 0.23833048 |
| FWER p-Value | 0.82 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SNN | NA | SNN Entrez, Source | stannin | 95 | 3.500 | 0.0238 | No |
| 2 | PCSK5 | NA | PCSK5 Entrez, Source | proprotein convertase subtilisin/kexin type 5 | 244 | 3.190 | 0.0433 | No |
| 3 | ZNF428 | NA | ZNF428 Entrez, Source | zinc finger protein 428 | 298 | 3.079 | 0.0654 | No |
| 4 | RHOJ | NA | RHOJ Entrez, Source | ras homolog gene family, member J | 378 | 2.959 | 0.0856 | No |
| 5 | SEMA5B | NA | SEMA5B Entrez, Source | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 409 | 2.912 | 0.1073 | No |
| 6 | COL11A2 | NA | COL11A2 Entrez, Source | collagen, type XI, alpha 2 | 462 | 2.857 | 0.1277 | No |
| 7 | RASA4 | NA | RASA4 Entrez, Source | RAS p21 protein activator 4 | 670 | 2.598 | 0.1404 | No |
| 8 | FADS2 | NA | FADS2 Entrez, Source | fatty acid desaturase 2 | 706 | 2.569 | 0.1591 | No |
| 9 | STMN3 | NA | STMN3 Entrez, Source | stathmin-like 3 | 1090 | 2.249 | 0.1626 | No |
| 10 | CACNG4 | NA | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 1243 | 2.138 | 0.1737 | No |
| 11 | RASD1 | NA | RASD1 Entrez, Source | RAS, dexamethasone-induced 1 | 2024 | 1.711 | 0.1584 | No |
| 12 | CUEDC2 | NA | CUEDC2 Entrez, Source | CUE domain containing 2 | 2206 | 1.630 | 0.1645 | No |
| 13 | TRAF4 | NA | TRAF4 Entrez, Source | TNF receptor-associated factor 4 | 2327 | 1.585 | 0.1725 | No |
| 14 | MRAS | NA | MRAS Entrez, Source | muscle RAS oncogene homolog | 2405 | 1.544 | 0.1817 | No |
| 15 | TMEM151B | NA | 2792 | 1.388 | 0.1784 | No | ||
| 16 | RENBP | NA | RENBP Entrez, Source | renin binding protein | 3299 | 1.215 | 0.1693 | No |
| 17 | FST | NA | FST Entrez, Source | follistatin | 3439 | 1.172 | 0.1733 | No |
| 18 | STAT5B | NA | STAT5B Entrez, Source | signal transducer and activator of transcription 5B | 3698 | 1.083 | 0.1723 | No |
| 19 | FAM64A | NA | FAM64A Entrez, Source | family with sequence similarity 64, member A | 3899 | 1.018 | 0.1729 | No |
| 20 | FAM73B | NA | FAM73B Entrez, Source | family with sequence similarity 73, member B | 4057 | 0.969 | 0.1747 | No |
| 21 | CDC7 | NA | CDC7 Entrez, Source | CDC7 cell division cycle 7 (S. cerevisiae) | 4353 | 0.894 | 0.1708 | No |
| 22 | TEAD1 | NA | TEAD1 Entrez, Source | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 4457 | 0.871 | 0.1738 | No |
| 23 | ALK | NA | ALK Entrez, Source | anaplastic lymphoma kinase (Ki-1) | 4504 | 0.861 | 0.1789 | No |
| 24 | GLIS2 | NA | GLIS2 Entrez, Source | GLIS family zinc finger 2 | 4507 | 0.860 | 0.1855 | No |
| 25 | TAL2 | NA | TAL2 Entrez, Source | T-cell acute lymphocytic leukemia 2 | 4581 | 0.844 | 0.1894 | No |
| 26 | PPP1R15B | NA | PPP1R15B Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 15B | 4731 | 0.804 | 0.1902 | No |
| 27 | EFTUD2 | NA | EFTUD2 Entrez, Source | elongation factor Tu GTP binding domain containing 2 | 4999 | 0.743 | 0.1862 | No |
| 28 | RGS16 | NA | RGS16 Entrez, Source | regulator of G-protein signalling 16 | 5686 | 0.580 | 0.1655 | No |
| 29 | C9orf89 | NA | C9ORF89 Entrez, Source | chromosome 9 open reading frame 89 | 6124 | 0.508 | 0.1534 | No |
| 30 | RIPK3 | NA | RIPK3 Entrez, Source | receptor-interacting serine-threonine kinase 3 | 6673 | 0.432 | 0.1367 | No |
| 31 | EIF1B | NA | EIF1B Entrez, Source | eukaryotic translation initiation factor 1B | 6875 | 0.410 | 0.1325 | No |
| 32 | ZBTB17 | NA | ZBTB17 Entrez, Source | zinc finger and BTB domain containing 17 | 6943 | 0.403 | 0.1332 | No |
| 33 | ART1 | NA | ART1 Entrez, Source | ADP-ribosyltransferase 1 | 7921 | 0.308 | 0.0996 | No |
| 34 | ERG | NA | ERG Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog (avian) | 7955 | 0.304 | 0.1008 | No |
| 35 | POLR2I | NA | POLR2I Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 8017 | 0.299 | 0.1009 | No |
| 36 | GREM2 | NA | GREM2 Entrez, Source | gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) | 8463 | 0.265 | 0.0866 | No |
| 37 | SLC13A2 | NA | SLC13A2 Entrez, Source | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 | 8698 | 0.248 | 0.0800 | No |
| 38 | CRTAC1 | NA | CRTAC1 Entrez, Source | cartilage acidic protein 1 | 8997 | 0.230 | 0.0708 | No |
| 39 | MBD3 | NA | MBD3 Entrez, Source | methyl-CpG binding domain protein 3 | 10082 | 0.175 | 0.0323 | No |
| 40 | POLD2 | NA | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 10700 | 0.146 | 0.0108 | No |
| 41 | NKX2-8 | NA | NKX2-8 Entrez, Source | NK2 transcription factor related, locus 8 (Drosophila) | 10740 | 0.144 | 0.0105 | No |
| 42 | SGSM3 | NA | 11268 | 0.119 | -0.0080 | No | ||
| 43 | ATP2A1 | NA | ATP2A1 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 11689 | 0.102 | -0.0226 | No |
| 44 | NPPB | NA | NPPB Entrez, Source | natriuretic peptide precursor B | 11836 | 0.096 | -0.0272 | No |
| 45 | AVP | NA | AVP Entrez, Source | arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) | 12409 | 0.075 | -0.0477 | No |
| 46 | FGF10 | NA | FGF10 Entrez, Source | fibroblast growth factor 10 | 12772 | 0.061 | -0.0605 | No |
| 47 | ELOF1 | NA | ELOF1 Entrez, Source | elongation factor 1 homolog (S. cerevisiae) | 13182 | 0.046 | -0.0752 | No |
| 48 | HINT1 | NA | HINT1 Entrez, Source | histidine triad nucleotide binding protein 1 | 13228 | 0.044 | -0.0765 | No |
| 49 | ZBTB12 | NA | ZBTB12 Entrez, Source | zinc finger and BTB domain containing 12 | 13265 | 0.042 | -0.0775 | No |
| 50 | DUSP13 | NA | DUSP13 Entrez, Source | dual specificity phosphatase 13 | 13300 | 0.041 | -0.0784 | No |
| 51 | GC | NA | GC Entrez, Source | group-specific component (vitamin D binding protein) | 13564 | 0.030 | -0.0878 | No |
| 52 | PIWIL1 | NA | PIWIL1 Entrez, Source | piwi-like 1 (Drosophila) | 14979 | -0.020 | -0.1397 | No |
| 53 | SLC11A1 | NA | SLC11A1 Entrez, Source | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 15015 | -0.022 | -0.1408 | No |
| 54 | AQP5 | NA | AQP5 Entrez, Source | aquaporin 5 | 15052 | -0.023 | -0.1419 | No |
| 55 | PF4 | NA | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 15523 | -0.042 | -0.1589 | No |
| 56 | LITAF | NA | LITAF Entrez, Source | lipopolysaccharide-induced TNF factor | 15574 | -0.044 | -0.1604 | No |
| 57 | MYOZ2 | NA | MYOZ2 Entrez, Source | myozenin 2 | 15594 | -0.044 | -0.1607 | No |
| 58 | NXNL1 | NA | 17327 | -0.116 | -0.2235 | No | ||
| 59 | CYBA | NA | CYBA Entrez, Source | cytochrome b-245, alpha polypeptide | 17388 | -0.119 | -0.2247 | No |
| 60 | TINAG | NA | TINAG Entrez, Source | tubulointerstitial nephritis antigen | 17657 | -0.132 | -0.2336 | No |
| 61 | SLC22A3 | NA | SLC22A3 Entrez, Source | solute carrier family 22 (extraneuronal monoamine transporter), member 3 | 17833 | -0.143 | -0.2389 | No |
| 62 | C7orf70 | NA | 18019 | -0.154 | -0.2445 | No | ||
| 63 | DCTPP1 | NA | 18916 | -0.219 | -0.2757 | No | ||
| 64 | RACGAP1 | NA | RACGAP1 Entrez, Source | Rac GTPase activating protein 1 | 19282 | -0.250 | -0.2872 | No |
| 65 | VSIG2 | NA | VSIG2 Entrez, Source | V-set and immunoglobulin domain containing 2 | 19604 | -0.281 | -0.2968 | No |
| 66 | PARS2 | NA | PARS2 Entrez, Source | prolyl-tRNA synthetase (mitochondrial)(putative) | 19743 | -0.294 | -0.2996 | No |
| 67 | USP13 | NA | USP13 Entrez, Source | ubiquitin specific peptidase 13 (isopeptidase T-3) | 19785 | -0.298 | -0.2987 | No |
| 68 | SIM1 | NA | SIM1 Entrez, Source | single-minded homolog 1 (Drosophila) | 19952 | -0.315 | -0.3024 | No |
| 69 | SLC7A9 | NA | SLC7A9 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 | 20132 | -0.335 | -0.3063 | No |
| 70 | GPN3 | NA | 20228 | -0.345 | -0.3071 | No | ||
| 71 | LSM4 | NA | LSM4 Entrez, Source | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 20306 | -0.356 | -0.3072 | No |
| 72 | GFER | NA | GFER Entrez, Source | growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) | 20492 | -0.379 | -0.3110 | No |
| 73 | TRAF2 | NA | TRAF2 Entrez, Source | TNF receptor-associated factor 2 | 20608 | -0.393 | -0.3122 | No |
| 74 | NSMCE1 | NA | NSMCE1 Entrez, Source | non-SMC element 1 homolog (S. cerevisiae) | 20720 | -0.410 | -0.3131 | No |
| 75 | SNRPB | NA | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 20945 | -0.445 | -0.3178 | No |
| 76 | C12orf10 | NA | C12ORF10 Entrez, Source | chromosome 12 open reading frame 10 | 21006 | -0.453 | -0.3165 | No |
| 77 | QTRT1 | NA | QTRT1 Entrez, Source | queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase) | 21131 | -0.472 | -0.3174 | No |
| 78 | CASP7 | NA | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 21218 | -0.483 | -0.3167 | No |
| 79 | FOXI1 | NA | FOXI1 Entrez, Source | forkhead box I1 | 21226 | -0.485 | -0.3132 | No |
| 80 | SPATA13 | NA | SPATA13 Entrez, Source | spermatogenesis associated 13 | 22141 | -0.655 | -0.3417 | Yes |
| 81 | HYAL3 | NA | HYAL3 Entrez, Source | hyaluronoglucosaminidase 3 | 22261 | -0.679 | -0.3408 | Yes |
| 82 | C11orf31 | NA | C11ORF31 Entrez, Source | chromosome 11 open reading frame 31 | 22378 | -0.703 | -0.3395 | Yes |
| 83 | B4GALT4 | NA | B4GALT4 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | 22390 | -0.705 | -0.3344 | Yes |
| 84 | C11orf71 | NA | C11ORF71 Entrez, Source | chromosome 11 open reading frame 71 | 22492 | -0.728 | -0.3325 | Yes |
| 85 | EXOSC2 | NA | EXOSC2 Entrez, Source | exosome component 2 | 22502 | -0.730 | -0.3271 | Yes |
| 86 | BIRC5 | NA | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 22533 | -0.737 | -0.3224 | Yes |
| 87 | CCNB2 | NA | CCNB2 Entrez, Source | cyclin B2 | 22659 | -0.766 | -0.3211 | Yes |
| 88 | GRTP1 | NA | GRTP1 Entrez, Source | growth hormone regulated TBC protein 1 | 22683 | -0.770 | -0.3159 | Yes |
| 89 | C17orf90 | NA | 22954 | -0.830 | -0.3193 | Yes | ||
| 90 | SULT1B1 | NA | SULT1B1 Entrez, Source | sulfotransferase family, cytosolic, 1B, member 1 | 23130 | -0.865 | -0.3190 | Yes |
| 91 | SEMA6B | NA | SEMA6B Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 23281 | -0.897 | -0.3175 | Yes |
| 92 | C16orf48 | NA | C16ORF48 Entrez, Source | chromosome 16 open reading frame 48 | 23525 | -0.958 | -0.3190 | Yes |
| 93 | ABCG4 | NA | ABCG4 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 4 | 23526 | -0.958 | -0.3115 | Yes |
| 94 | SNRPC | NA | SNRPC Entrez, Source | small nuclear ribonucleoprotein polypeptide C | 23619 | -0.985 | -0.3072 | Yes |
| 95 | KIF20A | NA | KIF20A Entrez, Source | kinesin family member 20A | 23668 | -0.998 | -0.3011 | Yes |
| 96 | UBE2C | NA | UBE2C Entrez, Source | ubiquitin-conjugating enzyme E2C | 23775 | -1.029 | -0.2970 | Yes |
| 97 | PDZK1 | NA | PDZK1 Entrez, Source | PDZ domain containing 1 | 23777 | -1.029 | -0.2890 | Yes |
| 98 | SDF2L1 | NA | SDF2L1 Entrez, Source | stromal cell-derived factor 2-like 1 | 23896 | -1.063 | -0.2850 | Yes |
| 99 | RABEPK | NA | RABEPK Entrez, Source | Rab9 effector protein with kelch motifs | 24148 | -1.134 | -0.2854 | Yes |
| 100 | CHCHD6 | NA | CHCHD6 Entrez, Source | coiled-coil-helix-coiled-coil-helix domain containing 6 | 24291 | -1.177 | -0.2814 | Yes |
| 101 | CRB3 | NA | CRB3 Entrez, Source | crumbs homolog 3 (Drosophila) | 24436 | -1.222 | -0.2772 | Yes |
| 102 | WNT2B | NA | WNT2B Entrez, Source | wingless-type MMTV integration site family, member 2B | 24550 | -1.261 | -0.2715 | Yes |
| 103 | RGL3 | NA | RGL3 Entrez, Source | ral guanine nucleotide dissociation stimulator-like 3 | 24562 | -1.267 | -0.2620 | Yes |
| 104 | TK1 | NA | TK1 Entrez, Source | thymidine kinase 1, soluble | 24625 | -1.283 | -0.2543 | Yes |
| 105 | OAF | NA | OAF Entrez, Source | OAF homolog (Drosophila) | 24649 | -1.293 | -0.2450 | Yes |
| 106 | SLC29A1 | NA | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 24888 | -1.374 | -0.2430 | Yes |
| 107 | SNTA1 | NA | SNTA1 Entrez, Source | syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) | 24914 | -1.385 | -0.2331 | Yes |
| 108 | SIM2 | NA | SIM2 Entrez, Source | single-minded homolog 2 (Drosophila) | 24935 | -1.390 | -0.2230 | Yes |
| 109 | SLC43A3 | NA | SLC43A3 Entrez, Source | solute carrier family 43, member 3 | 25159 | -1.487 | -0.2196 | Yes |
| 110 | HMGA2 | NA | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 25163 | -1.488 | -0.2081 | Yes |
| 111 | ICA1 | NA | ICA1 Entrez, Source | islet cell autoantigen 1, 69kDa | 25655 | -1.714 | -0.2127 | Yes |
| 112 | RSPH9 | NA | 25683 | -1.734 | -0.2002 | Yes | ||
| 113 | RASGRF1 | NA | RASGRF1 Entrez, Source | Ras protein-specific guanine nucleotide-releasing factor 1 | 25761 | -1.774 | -0.1891 | Yes |
| 114 | RUVBL2 | NA | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 25822 | -1.806 | -0.1772 | Yes |
| 115 | AURKB | NA | AURKB Entrez, Source | aurora kinase B | 25936 | -1.878 | -0.1667 | Yes |
| 116 | AURKA | NA | AURKA Entrez, Source | aurora kinase A | 26048 | -1.947 | -0.1556 | Yes |
| 117 | NKD2 | NA | NKD2 Entrez, Source | naked cuticle homolog 2 (Drosophila) | 26125 | -1.998 | -0.1428 | Yes |
| 118 | CRLF1 | NA | CRLF1 Entrez, Source | cytokine receptor-like factor 1 | 26139 | -2.008 | -0.1276 | Yes |
| 119 | KIF22 | NA | KIF22 Entrez, Source | kinesin family member 22 | 26236 | -2.080 | -0.1149 | Yes |
| 120 | MYLK | NA | MYLK Entrez, Source | myosin, light chain kinase | 26239 | -2.081 | -0.0987 | Yes |
| 121 | ANAPC5 | NA | ANAPC5 Entrez, Source | anaphase promoting complex subunit 5 | 26309 | -2.139 | -0.0845 | Yes |
| 122 | ATP2A3 | NA | ATP2A3 Entrez, Source | ATPase, Ca++ transporting, ubiquitous | 26582 | -2.368 | -0.0760 | Yes |
| 123 | CHCHD7 | NA | CHCHD7 Entrez, Source | coiled-coil-helix-coiled-coil-helix domain containing 7 | 26887 | -2.793 | -0.0654 | Yes |
| 124 | IER3 | NA | IER3 Entrez, Source | immediate early response 3 | 27068 | -3.228 | -0.0468 | Yes |
| 125 | CMTM7 | NA | CMTM7 Entrez, Source | CKLF-like MARVEL transmembrane domain containing 7 | 27151 | -3.547 | -0.0221 | Yes |
| 126 | TWIST2 | NA | TWIST2 Entrez, Source | twist homolog 2 (Drosophila) | 27175 | -3.661 | 0.0057 | Yes |
