Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | SINGH_KRAS_DEPENDENCY_SIGNATURE_ |
| Enrichment Score (ES) | -0.5477681 |
| Normalized Enrichment Score (NES) | -1.3777481 |
| Nominal p-value | 0.085365854 |
| FDR q-value | 0.13552348 |
| FWER p-Value | 0.577 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TGFA | NA | TGFA Entrez, Source | transforming growth factor, alpha | 5132 | 0.712 | -0.1240 | No |
| 2 | C6orf141 | NA | C6ORF141 Entrez, Source | chromosome 6 open reading frame 141 | 5558 | 0.604 | -0.0854 | No |
| 3 | DAPP1 | NA | DAPP1 Entrez, Source | dual adaptor of phosphotyrosine and 3-phosphoinositides | 12269 | 0.080 | -0.3238 | No |
| 4 | LAD1 | NA | LAD1 Entrez, Source | ladinin 1 | 13168 | 0.046 | -0.3526 | No |
| 5 | FAM83A | NA | FAM83A Entrez, Source | family with sequence similarity 83, member A | 15320 | -0.034 | -0.4283 | No |
| 6 | MST1R | NA | MST1R Entrez, Source | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | 15560 | -0.043 | -0.4332 | No |
| 7 | C1orf116 | NA | C1ORF116 Entrez, Source | chromosome 1 open reading frame 116 | 16809 | -0.094 | -0.4705 | No |
| 8 | SH2D3A | NA | SH2D3A Entrez, Source | SH2 domain containing 3A | 17273 | -0.113 | -0.4773 | No |
| 9 | SDR16C5 | NA | 17882 | -0.146 | -0.4865 | No | ||
| 10 | CLDN7 | NA | CLDN7 Entrez, Source | claudin 7 | 18028 | -0.155 | -0.4779 | No |
| 11 | SEMA4B | NA | SEMA4B Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 19937 | -0.314 | -0.5196 | Yes |
| 12 | TMEM45B | NA | TMEM45B Entrez, Source | transmembrane protein 45B | 20454 | -0.375 | -0.5048 | Yes |
| 13 | ADAM8 | NA | ADAM8 Entrez, Source | ADAM metallopeptidase domain 8 | 20906 | -0.438 | -0.4820 | Yes |
| 14 | MAOA | NA | MAOA Entrez, Source | monoamine oxidase A | 21228 | -0.486 | -0.4502 | Yes |
| 15 | PRSS22 | NA | PRSS22 Entrez, Source | protease, serine, 22 | 22184 | -0.662 | -0.4258 | Yes |
| 16 | FGFBP1 | NA | FGFBP1 Entrez, Source | fibroblast growth factor binding protein 1 | 22505 | -0.732 | -0.3718 | Yes |
| 17 | LAMA3 | NA | LAMA3 Entrez, Source | laminin, alpha 3 | 24247 | -1.164 | -0.3312 | Yes |
| 18 | LAMC2 | NA | LAMC2 Entrez, Source | laminin, gamma 2 | 24814 | -1.349 | -0.2308 | Yes |
| 19 | AMPD3 | NA | AMPD3 Entrez, Source | adenosine monophosphate deaminase (isoform E) | 25169 | -1.490 | -0.1101 | Yes |
| 20 | AREG | NA | AREG Entrez, Source | amphiregulin (schwannoma-derived growth factor) | 26274 | -2.108 | 0.0386 | Yes |
