Datasetexpression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls
#wt_versus_radiation.mainSample.cls
#wt_versus_radiation_repos
PhenotypemainSample.cls#wt_versus_radiation_repos
Upregulated in class2
GeneSetSIRNA_EIF4GI_UP
Enrichment Score (ES)-0.39076936
Normalized Enrichment Score (NES)-1.3986592
Nominal p-value0.025477707
FDR q-value0.2256265
FWER p-Value0.524
Table: GSEA Results Summary



Fig 1: Enrichment plot: SIRNA_EIF4GI_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ASAH1NAASAH1
Entrez,  Source
N-acylsphingosine amidohydrolase (acid ceramidase) 15012.7920.0089No
2TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein8062.4660.0218No
3C7orf10NAC7ORF10
Entrez,  Source
chromosome 7 open reading frame 108762.4090.0428No
4PSAPNAPSAP
Entrez,  Source
prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)9032.3880.0651No
5PMPCBNAPMPCB
Entrez,  Source
peptidase (mitochondrial processing) beta12662.1260.0726No
6TCF25NATCF25
Entrez,  Source
transcription factor 25 (basic helix-loop-helix)12982.1020.0920No
7CA2NACA2
Entrez,  Source
carbonic anhydrase II17351.8540.0941No
8DAG1NADAG1
Entrez,  Source
dystroglycan 1 (dystrophin-associated glycoprotein 1)17821.8340.1103No
9PTPN13NAPTPN13
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)18291.8090.1262No
10BTG2NABTG2
Entrez,  Source
BTG family, member 220491.6970.1348No
11ATP5A1NAATP5A1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle20581.6930.1510No
12PAPSS1NAPAPSS1
Entrez,  Source
3'-phosphoadenosine 5'-phosphosulfate synthase 123091.5910.1574No
13TCTN1NA28141.3810.1523No
14MAGEF1NAMAGEF1
Entrez,  Source
melanoma antigen family F, 132711.2210.1475No
15IGF2RNAIGF2R
Entrez,  Source
insulin-like growth factor 2 receptor37241.0750.1414No
16UBE2E1NAUBE2E1
Entrez,  Source
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)40200.9790.1402No
17ATF3NAATF3
Entrez,  Source
activating transcription factor 342200.9270.1419No
18KIF2ANAKIF2A
Entrez,  Source
kinesin heavy chain member 2A44660.8690.1414No
19EID1NAEID1
Entrez,  Source
EP300 interacting inhibitor of differentiation 150620.7310.1267No
20CTSHNACTSH
Entrez,  Source
cathepsin H51190.7150.1316No
21ZFP36L2NAZFP36L2
Entrez,  Source
zinc finger protein 36, C3H type-like 251440.7090.1376No
22HSPB1NAHSPB1
Entrez,  Source
heat shock 27kDa protein 155690.6020.1280No
23PYGLNAPYGL
Entrez,  Source
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)56080.5950.1324No
24INPP5DNAINPP5D
Entrez,  Source
inositol polyphosphate-5-phosphatase, 145kDa57140.5760.1341No
25NQO1NANQO1
Entrez,  Source
NAD(P)H dehydrogenase, quinone 158110.5580.1361No
26FBXO46NAFBXO46
Entrez,  Source
F-box protein 4666260.4370.1105No
27TRAF3IP2NATRAF3IP2
Entrez,  Source
TRAF3 interacting protein 267490.4240.1101No
28D4S234ENAD4S234E
Entrez,  Source
-68560.4120.1102No
29MPV17NAMPV17
Entrez,  Source
MpV17 mitochondrial inner membrane protein68870.4090.1131No
30ATP1A1NAATP1A1
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 1 polypeptide69290.4040.1156No
31HTRA2NAHTRA2
Entrez,  Source
HtrA serine peptidase 269960.3970.1170No
32HADHBNAHADHB
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit69980.3970.1209No
33CEBPDNACEBPD
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), delta85520.2590.0664No
34ASS1NAASS1
Entrez,  Source
argininosuccinate synthetase 196950.1930.0263No
35NONONANONO
Entrez,  Source
non-POU domain containing, octamer-binding107250.145-0.0100No
36FXYD3NAFXYD3
Entrez,  Source
FXYD domain containing ion transport regulator 3107660.143-0.0101No
37SPRR1ANASPRR1A
Entrez,  Source
small proline-rich protein 1A113140.117-0.0290No
38CAMLGNACAMLG
Entrez,  Source
calcium modulating ligand120440.089-0.0549No
39FCARNAFCAR
Entrez,  Source
Fc fragment of IgA, receptor for127250.063-0.0793No
40XPCNAXPC
Entrez,  Source
xeroderma pigmentosum, complementation group C128060.060-0.0816No
41SPRR1BNASPRR1B
Entrez,  Source
small proline-rich protein 1B (cornifin)131260.048-0.0929No
42QARSNAQARS
Entrez,  Source
glutaminyl-tRNA synthetase138290.021-0.1184No
43SETDB1NASETDB1
Entrez,  Source
SET domain, bifurcated 115884-0.055-0.1933No
44MATR3NAMATR3
Entrez,  Source
matrin 316439-0.079-0.2129No
45WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 218222-0.167-0.2767No
46GPR15NAGPR15
Entrez,  Source
G protein-coupled receptor 1518372-0.176-0.2804No
47SAMM50NASAMM50
Entrez,  Source
sorting and assembly machinery component 50 homolog (S. cerevisiae)18572-0.190-0.2859No
48SLCO1A2NASLCO1A2
Entrez,  Source
solute carrier organic anion transporter family, member 1A219188-0.243-0.3061No
49SPG20NASPG20
Entrez,  Source
spastic paraplegia 20, spartin (Troyer syndrome)19288-0.250-0.3073No
50SAA1NASAA1
Entrez,  Source
serum amyloid A119376-0.258-0.3080No
51DDX54NADDX54
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5419681-0.287-0.3163No
52DDX50NADDX50
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5020495-0.380-0.3425No
53GIN1NA20519-0.382-0.3396No
54ST13NAST13
Entrez,  Source
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)20565-0.389-0.3374No
55DTX4NADTX4
Entrez,  Source
deltex 4 homolog (Drosophila)21079-0.464-0.3517No
56S100A14NAS100A14
Entrez,  Source
S100 calcium binding protein A1421230-0.486-0.3525No
57FRAT2NAFRAT2
Entrez,  Source
frequently rearranged in advanced T-cell lymphomas 221360-0.508-0.3523No
58GSSNAGSS
Entrez,  Source
glutathione synthetase21373-0.510-0.3477No
59NCAPD2NANCAPD2
Entrez,  Source
non-SMC condensin I complex, subunit D221700-0.570-0.3541No
60GLUD1NAGLUD1
Entrez,  Source
glutamate dehydrogenase 121742-0.579-0.3500No
61SLC25A3NASLC25A3
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 322165-0.659-0.3590No
62EIF3KNA22791-0.793-0.3742No
63SLC25A5NASLC25A5
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 523242-0.890-0.3821Yes
64DRG1NADRG1
Entrez,  Source
developmentally regulated GTP binding protein 123270-0.896-0.3743Yes
65UQCRC2NAUQCRC2
Entrez,  Source
ubiquinol-cytochrome c reductase core protein II23520-0.957-0.3741Yes
66CPNE1NACPNE1
Entrez,  Source
copine I23536-0.960-0.3653Yes
67CSDE1NACSDE1
Entrez,  Source
cold shock domain containing E1, RNA-binding23635-0.988-0.3593Yes
68RMND1NA23734-1.016-0.3529Yes
69LETMD1NALETMD1
Entrez,  Source
LETM1 domain containing 123876-1.059-0.3478Yes
70PSME1NAPSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)23933-1.073-0.3394Yes
71THADANATHADA
Entrez,  Source
thyroid adenoma associated23987-1.086-0.3307Yes
72ZBED1NAZBED1
Entrez,  Source
zinc finger, BED-type containing 124457-1.229-0.3359Yes
73LRPAP1NALRPAP1
Entrez,  Source
low density lipoprotein receptor-related protein associated protein 124477-1.235-0.3246Yes
74ESYT1NA24537-1.257-0.3145Yes
75NDUFS8NANDUFS8
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)24740-1.324-0.3089Yes
76ADSLNAADSL
Entrez,  Source
adenylosuccinate lyase25220-1.509-0.3118Yes
77MIA3NAMIA3
Entrez,  Source
melanoma inhibitory activity family, member 325545-1.661-0.3075Yes
78HSPD1NAHSPD1
Entrez,  Source
heat shock 60kDa protein 1 (chaperonin)25765-1.775-0.2982Yes
79LAP3NALAP3
Entrez,  Source
leucine aminopeptidase 325812-1.803-0.2823Yes
80CSE1LNACSE1L
Entrez,  Source
CSE1 chromosome segregation 1-like (yeast)25848-1.822-0.2658Yes
81PDHA1NAPDHA1
Entrez,  Source
pyruvate dehydrogenase (lipoamide) alpha 125871-1.839-0.2486Yes
82AFG3L2NAAFG3L2
Entrez,  Source
AFG3 ATPase family gene 3-like 2 (yeast)25938-1.879-0.2327Yes
83ALDH7A1NAALDH7A1
Entrez,  Source
aldehyde dehydrogenase 7 family, member A126299-2.130-0.2251Yes
84FAM158ANA26463-2.266-0.2090Yes
85MTO1NAMTO1
Entrez,  Source
mitochondrial translation optimization 1 homolog (S. cerevisiae)26598-2.380-0.1907Yes
86HLA-BNAHLA-B
Entrez,  Source
major histocompatibility complex, class I, B26685-2.482-0.1696Yes
87CTSCNACTSC
Entrez,  Source
cathepsin C26690-2.488-0.1455Yes
88CORO1BNACORO1B
Entrez,  Source
coronin, actin binding protein, 1B26738-2.548-0.1223Yes
89CCT4NACCT4
Entrez,  Source
chaperonin containing TCP1, subunit 4 (delta)26763-2.581-0.0980Yes
90MRPS30NAMRPS30
Entrez,  Source
mitochondrial ribosomal protein S3026847-2.746-0.0742Yes
91C12orf11NAC12ORF11
Entrez,  Source
chromosome 12 open reading frame 1126996-3.035-0.0500Yes
92TNNT1NATNNT1
Entrez,  Source
troponin T type 1 (skeletal, slow)27044-3.163-0.0209Yes
93PERPNAPERP
Entrez,  Source
PERP, TP53 apoptosis effector27060-3.2080.0099Yes
Table: GSEA details [plain text format]



Fig 2: SIRNA_EIF4GI_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SIRNA_EIF4GI_UP: Random ES distribution   
Gene set null distribution of ES for SIRNA_EIF4GI_UP