Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | ACTIN_POLYMERIZATION_AND_OR_DEPOLYMERIZATION |
| Enrichment Score (ES) | 0.6001539 |
| Normalized Enrichment Score (NES) | 1.6655563 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.06408278 |
| FWER p-Value | 0.375 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | EVL | NA | EVL Entrez, Source | Enah/Vasp-like | 100 | 3.487 | 0.1269 | Yes |
| 2 | NCK2 | NA | NCK2 Entrez, Source | NCK adaptor protein 2 | 415 | 2.906 | 0.2242 | Yes |
| 3 | PREX1 | NA | PREX1 Entrez, Source | - | 499 | 2.796 | 0.3259 | Yes |
| 4 | LIMA1 | NA | LIMA1 Entrez, Source | LIM domain and actin binding 1 | 617 | 2.658 | 0.4212 | Yes |
| 5 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 869 | 2.415 | 0.5024 | Yes |
| 6 | GSN | NA | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 1877 | 1.789 | 0.5325 | Yes |
| 7 | CDC42EP5 | NA | CDC42EP5 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 5 | 3136 | 1.262 | 0.5337 | Yes |
| 8 | WASL | NA | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 3245 | 1.226 | 0.5756 | Yes |
| 9 | WASF3 | NA | WASF3 Entrez, Source | WAS protein family, member 3 | 3687 | 1.086 | 0.6002 | Yes |
| 10 | CAPG | NA | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 4876 | 0.772 | 0.5856 | No |
| 11 | WIPF1 | NA | WIPF1 Entrez, Source | WAS/WASL interacting protein family, member 1 | 5979 | 0.531 | 0.5651 | No |
| 12 | NCK1 | NA | NCK1 Entrez, Source | NCK adaptor protein 1 | 6863 | 0.412 | 0.5482 | No |
| 13 | ARF6 | NA | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 13142 | 0.047 | 0.3200 | No |
| 14 | GHRL | NA | GHRL Entrez, Source | ghrelin/obestatin preprohormone | 14071 | 0.012 | 0.2865 | No |
| 15 | TMSB4Y | NA | TMSB4Y Entrez, Source | thymosin, beta 4, Y-linked | 16657 | -0.087 | 0.1951 | No |
| 16 | CXCL12 | NA | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 17216 | -0.111 | 0.1788 | No |
| 17 | LATS1 | NA | LATS1 Entrez, Source | LATS, large tumor suppressor, homolog 1 (Drosophila) | 19021 | -0.229 | 0.1213 | No |
| 18 | GHSR | NA | GHSR Entrez, Source | growth hormone secretagogue receptor | 19478 | -0.268 | 0.1147 | No |
| 19 | RASA1 | NA | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 21094 | -0.467 | 0.0730 | No |
| 20 | ANG | NA | ANG Entrez, Source | angiogenin, ribonuclease, RNase A family, 5 | 21162 | -0.475 | 0.0883 | No |
| 21 | DSTN | NA | DSTN Entrez, Source | destrin (actin depolymerizing factor) | 23829 | -1.045 | 0.0298 | No |
| 22 | CDC42EP2 | NA | CDC42EP2 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 2 | 24413 | -1.214 | 0.0539 | No |
| 23 | WASF1 | NA | WASF1 Entrez, Source | WAS protein family, member 1 | 24984 | -1.411 | 0.0859 | No |
