Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | CELLULAR_CATION_HOMEOSTASIS |
| Enrichment Score (ES) | 0.40569288 |
| Normalized Enrichment Score (NES) | 1.7218859 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.044872906 |
| FWER p-Value | 0.251 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CXCR4 | NA | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 51 | 3.653 | 0.0458 | Yes |
| 2 | SRI | NA | SRI Entrez, Source | sorcin | 99 | 3.489 | 0.0896 | Yes |
| 3 | APP | NA | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 128 | 3.406 | 0.1329 | Yes |
| 4 | THY1 | NA | THY1 Entrez, Source | Thy-1 cell surface antigen | 240 | 3.194 | 0.1705 | Yes |
| 5 | CLN5 | NA | CLN5 Entrez, Source | ceroid-lipofuscinosis, neuronal 5 | 374 | 2.965 | 0.2043 | Yes |
| 6 | SLC40A1 | NA | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 550 | 2.715 | 0.2333 | Yes |
| 7 | ATP1A2 | NA | ATP1A2 Entrez, Source | ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide | 579 | 2.691 | 0.2674 | Yes |
| 8 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 718 | 2.553 | 0.2956 | Yes |
| 9 | PLCE1 | NA | PLCE1 Entrez, Source | phospholipase C, epsilon 1 | 1480 | 1.990 | 0.2936 | Yes |
| 10 | MCHR1 | NA | MCHR1 Entrez, Source | melanin-concentrating hormone receptor 1 | 1505 | 1.974 | 0.3185 | Yes |
| 11 | PPT1 | NA | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 1566 | 1.942 | 0.3416 | Yes |
| 12 | BUD31 | NA | BUD31 Entrez, Source | BUD31 homolog (yeast) | 1587 | 1.930 | 0.3660 | Yes |
| 13 | S1PR3 | NA | 1659 | 1.893 | 0.3881 | Yes | ||
| 14 | CCR1 | NA | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 2059 | 1.692 | 0.3955 | Yes |
| 15 | CACNA1A | NA | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 2344 | 1.578 | 0.4057 | Yes |
| 16 | ATOX1 | NA | ATOX1 Entrez, Source | ATX1 antioxidant protein 1 homolog (yeast) | 3494 | 1.157 | 0.3786 | No |
| 17 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 3584 | 1.126 | 0.3900 | No |
| 18 | TFR2 | NA | TFR2 Entrez, Source | transferrin receptor 2 | 3731 | 1.073 | 0.3986 | No |
| 19 | CHRNA7 | NA | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 4214 | 0.927 | 0.3930 | No |
| 20 | AGTR1 | NA | AGTR1 Entrez, Source | angiotensin II receptor, type 1 | 5129 | 0.713 | 0.3687 | No |
| 21 | FTL | NA | FTL Entrez, Source | ferritin, light polypeptide | 5182 | 0.700 | 0.3760 | No |
| 22 | BCL2 | NA | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 5191 | 0.697 | 0.3848 | No |
| 23 | ATP7A | NA | ATP7A Entrez, Source | ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) | 5313 | 0.659 | 0.3889 | No |
| 24 | OPRL1 | NA | OPRL1 Entrez, Source | opiate receptor-like 1 | 5330 | 0.654 | 0.3969 | No |
| 25 | PROK2 | NA | PROK2 Entrez, Source | prokineticin 2 | 5633 | 0.591 | 0.3935 | No |
| 26 | CLCN3 | NA | CLCN3 Entrez, Source | chloride channel 3 | 6866 | 0.411 | 0.3536 | No |
| 27 | ATP1A1 | NA | ATP1A1 Entrez, Source | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 6929 | 0.404 | 0.3566 | No |
| 28 | CCR7 | NA | CCR7 Entrez, Source | chemokine (C-C motif) receptor 7 | 7252 | 0.370 | 0.3496 | No |
| 29 | CCL15 | NA | CCL15 Entrez, Source | chemokine (C-C motif) ligand 15 | 7727 | 0.323 | 0.3364 | No |
| 30 | CYSLTR1 | NA | CYSLTR1 Entrez, Source | cysteinyl leukotriene receptor 1 | 7949 | 0.305 | 0.3323 | No |
| 31 | DRD1 | NA | DRD1 Entrez, Source | dopamine receptor D1 | 7969 | 0.303 | 0.3355 | No |
| 32 | LPAR3 | NA | 8355 | 0.273 | 0.3249 | No | ||
| 33 | CASR | NA | CASR Entrez, Source | calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) | 8615 | 0.255 | 0.3187 | No |
| 34 | HPX | NA | HPX Entrez, Source | hemopexin | 8685 | 0.249 | 0.3195 | No |
| 35 | CCKBR | NA | CCKBR Entrez, Source | cholecystokinin B receptor | 9421 | 0.207 | 0.2952 | No |
| 36 | CXCL13 | NA | CXCL13 Entrez, Source | chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) | 9427 | 0.207 | 0.2977 | No |
| 37 | RGN | NA | RGN Entrez, Source | regucalcin (senescence marker protein-30) | 9589 | 0.198 | 0.2944 | No |
| 38 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 9704 | 0.193 | 0.2927 | No |
| 39 | TRPV4 | NA | TRPV4 Entrez, Source | transient receptor potential cation channel, subfamily V, member 4 | 9756 | 0.190 | 0.2933 | No |
| 40 | GALR2 | NA | GALR2 Entrez, Source | galanin receptor 2 | 10300 | 0.165 | 0.2755 | No |
| 41 | CLN3 | NA | CLN3 Entrez, Source | ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) | 10400 | 0.160 | 0.2740 | No |
| 42 | CCL7 | NA | CCL7 Entrez, Source | chemokine (C-C motif) ligand 7 | 10412 | 0.160 | 0.2756 | No |
| 43 | KNG1 | NA | KNG1 Entrez, Source | kininogen 1 | 10587 | 0.152 | 0.2712 | No |
| 44 | P2RY4 | NA | P2RY4 Entrez, Source | pyrimidinergic receptor P2Y, G-protein coupled, 4 | 10953 | 0.135 | 0.2596 | No |
| 45 | TAC1 | NA | TAC1 Entrez, Source | tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) | 11366 | 0.115 | 0.2460 | No |
| 46 | AVPR1B | NA | AVPR1B Entrez, Source | arginine vasopressin receptor 1B | 11673 | 0.103 | 0.2361 | No |
| 47 | CCL19 | NA | CCL19 Entrez, Source | chemokine (C-C motif) ligand 19 | 11737 | 0.100 | 0.2350 | No |
| 48 | CCR8 | NA | CCR8 Entrez, Source | chemokine (C-C motif) receptor 8 | 11969 | 0.091 | 0.2278 | No |
| 49 | CACNA1C | NA | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 12328 | 0.078 | 0.2156 | No |
| 50 | GCM2 | NA | GCM2 Entrez, Source | glial cells missing homolog 2 (Drosophila) | 12812 | 0.060 | 0.1987 | No |
| 51 | CCR4 | NA | CCR4 Entrez, Source | chemokine (C-C motif) receptor 4 | 12958 | 0.054 | 0.1940 | No |
| 52 | CCR3 | NA | CCR3 Entrez, Source | chemokine (C-C motif) receptor 3 | 13040 | 0.051 | 0.1917 | No |
| 53 | CP | NA | CP Entrez, Source | ceruloplasmin (ferroxidase) | 13305 | 0.041 | 0.1826 | No |
| 54 | CCR5 | NA | CCR5 Entrez, Source | chemokine (C-C motif) receptor 5 | 13865 | 0.020 | 0.1623 | No |
| 55 | CCL14 | NA | CCL14 Entrez, Source | chemokine (C-C motif) ligand 14 | 14052 | 0.013 | 0.1556 | No |
| 56 | GHRL | NA | GHRL Entrez, Source | ghrelin/obestatin preprohormone | 14071 | 0.012 | 0.1551 | No |
| 57 | CCL23 | NA | CCL23 Entrez, Source | chemokine (C-C motif) ligand 23 | 14077 | 0.012 | 0.1551 | No |
| 58 | CCR9 | NA | CCR9 Entrez, Source | chemokine (C-C motif) receptor 9 | 14699 | -0.009 | 0.1324 | No |
| 59 | CALCA | NA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 15001 | -0.021 | 0.1216 | No |
| 60 | CALR | NA | CALR Entrez, Source | calreticulin | 15362 | -0.035 | 0.1089 | No |
| 61 | CCR6 | NA | CCR6 Entrez, Source | chemokine (C-C motif) receptor 6 | 15455 | -0.039 | 0.1060 | No |
| 62 | AVPR1A | NA | AVPR1A Entrez, Source | arginine vasopressin receptor 1A | 15785 | -0.051 | 0.0946 | No |
| 63 | PTPRC | NA | PTPRC Entrez, Source | protein tyrosine phosphatase, receptor type, C | 15992 | -0.059 | 0.0878 | No |
| 64 | TMPRSS3 | NA | TMPRSS3 Entrez, Source | transmembrane protease, serine 3 | 16528 | -0.082 | 0.0692 | No |
| 65 | CCR2 | NA | CCR2 Entrez, Source | chemokine (C-C motif) receptor 2 | 16547 | -0.083 | 0.0696 | No |
| 66 | BDKRB1 | NA | BDKRB1 Entrez, Source | bradykinin receptor B1 | 16675 | -0.088 | 0.0661 | No |
| 67 | CCKAR | NA | CCKAR Entrez, Source | cholecystokinin A receptor | 16682 | -0.088 | 0.0671 | No |
| 68 | CCL1 | NA | CCL1 Entrez, Source | chemokine (C-C motif) ligand 1 | 16779 | -0.092 | 0.0647 | No |
| 69 | XCL1 | NA | XCL1 Entrez, Source | chemokine (C motif) ligand 1 | 16956 | -0.099 | 0.0596 | No |
| 70 | CLN6 | NA | CLN6 Entrez, Source | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | 16971 | -0.100 | 0.0604 | No |
| 71 | XCR1 | NA | XCR1 Entrez, Source | chemokine (C motif) receptor 1 | 17115 | -0.106 | 0.0565 | No |
| 72 | NMUR2 | NA | NMUR2 Entrez, Source | neuromedin U receptor 2 | 17137 | -0.107 | 0.0571 | No |
| 73 | CXCL12 | NA | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 17216 | -0.111 | 0.0557 | No |
| 74 | GLP1R | NA | GLP1R Entrez, Source | glucagon-like peptide 1 receptor | 17245 | -0.112 | 0.0561 | No |
| 75 | ATP1A4 | NA | ATP1A4 Entrez, Source | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 17574 | -0.128 | 0.0458 | No |
| 76 | C5AR1 | NA | C5AR1 Entrez, Source | complement component 5a receptor 1 | 17675 | -0.133 | 0.0438 | No |
| 77 | EDNRA | NA | EDNRA Entrez, Source | endothelin receptor type A | 18830 | -0.212 | 0.0042 | No |
| 78 | CD52 | NA | CD52 Entrez, Source | CD52 molecule | 18857 | -0.214 | 0.0060 | No |
| 79 | CCL3 | NA | CCL3 Entrez, Source | chemokine (C-C motif) ligand 3 | 18961 | -0.223 | 0.0051 | No |
| 80 | SAA1 | NA | SAA1 Entrez, Source | serum amyloid A1 | 19376 | -0.258 | -0.0067 | No |
| 81 | LCK | NA | LCK Entrez, Source | lymphocyte-specific protein tyrosine kinase | 19426 | -0.263 | -0.0051 | No |
| 82 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 19429 | -0.263 | -0.0017 | No |
| 83 | CLDN16 | NA | CLDN16 Entrez, Source | claudin 16 | 20246 | -0.348 | -0.0271 | No |
| 84 | SLC30A5 | NA | SLC30A5 Entrez, Source | solute carrier family 30 (zinc transporter), member 5 | 20644 | -0.398 | -0.0365 | No |
| 85 | CCL13 | NA | CCL13 Entrez, Source | chemokine (C-C motif) ligand 13 | 20652 | -0.399 | -0.0316 | No |
| 86 | S1PR4 | NA | 20825 | -0.426 | -0.0323 | No | ||
| 87 | ATP7B | NA | ATP7B Entrez, Source | ATPase, Cu++ transporting, beta polypeptide | 20836 | -0.428 | -0.0271 | No |
| 88 | CXCR3 | NA | CXCR3 Entrez, Source | chemokine (C-X-C motif) receptor 3 | 20996 | -0.452 | -0.0271 | No |
| 89 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 21108 | -0.469 | -0.0250 | No |
| 90 | FXN | NA | FXN Entrez, Source | frataxin | 21755 | -0.582 | -0.0412 | No |
| 91 | GNA15 | NA | GNA15 Entrez, Source | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 21787 | -0.589 | -0.0346 | No |
| 92 | CCL11 | NA | CCL11 Entrez, Source | chemokine (C-C motif) ligand 11 | 21975 | -0.625 | -0.0334 | No |
| 93 | LPAR2 | NA | 22257 | -0.679 | -0.0348 | No | ||
| 94 | FTH1 | NA | FTH1 Entrez, Source | ferritin, heavy polypeptide 1 | 23032 | -0.845 | -0.0522 | No |
| 95 | ATP2C1 | NA | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 23572 | -0.971 | -0.0594 | No |
| 96 | MTL5 | NA | MTL5 Entrez, Source | metallothionein-like 5, testis-specific (tesmin) | 23624 | -0.987 | -0.0484 | No |
| 97 | HFE | NA | HFE Entrez, Source | hemochromatosis | 23810 | -1.041 | -0.0416 | No |
| 98 | CD24 | NA | CD24 Entrez, Source | CD24 molecule | 24149 | -1.134 | -0.0392 | No |
| 99 | STC1 | NA | STC1 Entrez, Source | stanniocalcin 1 | 24330 | -1.189 | -0.0303 | No |
| 100 | SLC4A11 | NA | SLC4A11 Entrez, Source | solute carrier family 4, sodium bicarbonate transporter-like, member 11 | 24754 | -1.328 | -0.0285 | No |
| 101 | F2RL1 | NA | F2RL1 Entrez, Source | coagulation factor II (thrombin) receptor-like 1 | 24795 | -1.343 | -0.0125 | No |
| 102 | CD55 | NA | CD55 Entrez, Source | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 25423 | -1.602 | -0.0146 | No |
| 103 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 25669 | -1.721 | -0.0011 | No |
| 104 | MT2A | NA | MT2A Entrez, Source | metallothionein 2A | 26318 | -2.146 | 0.0030 | No |
| 105 | ATP1A3 | NA | ATP1A3 Entrez, Source | ATPase, Na+/K+ transporting, alpha 3 polypeptide | 26780 | -2.611 | 0.0202 | No |
