Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | G_PROTEIN_SIGNALING_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY |
| Enrichment Score (ES) | -0.6539878 |
| Normalized Enrichment Score (NES) | -1.899903 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.05960409 |
| FWER p-Value | 0.053 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | GNAS | NA | GNAS Entrez, Source | GNAS complex locus | 3075 | 1.285 | -0.0481 | No |
| 2 | CAP2 | NA | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 4185 | 0.936 | -0.0418 | No |
| 3 | DRD1 | NA | DRD1 Entrez, Source | dopamine receptor D1 | 7969 | 0.303 | -0.1651 | No |
| 4 | GHRH | NA | GHRH Entrez, Source | growth hormone releasing hormone | 8998 | 0.230 | -0.1912 | No |
| 5 | ADRB3 | NA | ADRB3 Entrez, Source | adrenergic, beta-3-, receptor | 10525 | 0.155 | -0.2393 | No |
| 6 | DRD5 | NA | DRD5 Entrez, Source | dopamine receptor D5 | 10739 | 0.144 | -0.2399 | No |
| 7 | ADCYAP1 | NA | ADCYAP1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) | 13232 | 0.044 | -0.3290 | No |
| 8 | ADORA3 | NA | ADORA3 Entrez, Source | adenosine A3 receptor | 13509 | 0.033 | -0.3374 | No |
| 9 | AVPR2 | NA | AVPR2 Entrez, Source | arginine vasopressin receptor 2 (nephrogenic diabetes insipidus) | 13934 | 0.017 | -0.3521 | No |
| 10 | CALCA | NA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 15001 | -0.021 | -0.3901 | No |
| 11 | CALCR | NA | CALCR Entrez, Source | calcitonin receptor | 15077 | -0.024 | -0.3916 | No |
| 12 | GHRHR | NA | GHRHR Entrez, Source | growth hormone releasing hormone receptor | 15734 | -0.050 | -0.4131 | No |
| 13 | ACR | NA | ACR Entrez, Source | acrosin | 17204 | -0.111 | -0.4614 | No |
| 14 | GLP1R | NA | GLP1R Entrez, Source | glucagon-like peptide 1 receptor | 17245 | -0.112 | -0.4572 | No |
| 15 | GIPR | NA | GIPR Entrez, Source | gastric inhibitory polypeptide receptor | 18335 | -0.174 | -0.4883 | No |
| 16 | EDNRA | NA | EDNRA Entrez, Source | endothelin receptor type A | 18830 | -0.212 | -0.4958 | No |
| 17 | CAP1 | NA | CAP1 Entrez, Source | CAP, adenylate cyclase-associated protein 1 (yeast) | 20201 | -0.341 | -0.5288 | No |
| 18 | GPR3 | NA | GPR3 Entrez, Source | G protein-coupled receptor 3 | 20303 | -0.356 | -0.5147 | No |
| 19 | P2RY11 | NA | P2RY11 Entrez, Source | purinergic receptor P2Y, G-protein coupled, 11 | 20648 | -0.399 | -0.5073 | No |
| 20 | CRHR1 | NA | CRHR1 Entrez, Source | corticotropin releasing hormone receptor 1 | 22759 | -0.786 | -0.5451 | No |
| 21 | ADCY7 | NA | ADCY7 Entrez, Source | adenylate cyclase 7 | 25733 | -1.754 | -0.5659 | Yes |
| 22 | PTHLH | NA | PTHLH Entrez, Source | parathyroid hormone-like hormone | 26693 | -2.489 | -0.4761 | Yes |
| 23 | ADRB1 | NA | ADRB1 Entrez, Source | adrenergic, beta-1-, receptor | 26938 | -2.889 | -0.3401 | Yes |
| 24 | ADRB2 | NA | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 27138 | -3.500 | -0.1718 | Yes |
| 25 | ADORA2B | NA | ADORA2B Entrez, Source | adenosine A2b receptor | 27155 | -3.561 | 0.0064 | Yes |
