Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | G_PROTEIN_SIGNALING_COUPLED_TO_CAMP_NUCLEOTIDE_SECOND_MESSENGER |
| Enrichment Score (ES) | -0.37377873 |
| Normalized Enrichment Score (NES) | -1.5819529 |
| Nominal p-value | 0.0018552876 |
| FDR q-value | 0.19675183 |
| FWER p-Value | 0.582 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DRD2 | NA | DRD2 Entrez, Source | dopamine receptor D2 | 902 | 2.388 | 0.0162 | No |
| 2 | GRK5 | NA | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 946 | 2.356 | 0.0633 | No |
| 3 | EDNRB | NA | EDNRB Entrez, Source | endothelin receptor type B | 1044 | 2.286 | 0.1069 | No |
| 4 | MCHR1 | NA | MCHR1 Entrez, Source | melanin-concentrating hormone receptor 1 | 1505 | 1.974 | 0.1308 | No |
| 5 | GABBR2 | NA | GABBR2 Entrez, Source | gamma-aminobutyric acid (GABA) B receptor, 2 | 1803 | 1.821 | 0.1576 | No |
| 6 | GNAI2 | NA | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 1832 | 1.807 | 0.1938 | No |
| 7 | GNAS | NA | GNAS Entrez, Source | GNAS complex locus | 3075 | 1.285 | 0.1748 | No |
| 8 | PRKACB | NA | PRKACB Entrez, Source | protein kinase, cAMP-dependent, catalytic, beta | 3597 | 1.118 | 0.1788 | No |
| 9 | CAP2 | NA | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 4185 | 0.936 | 0.1766 | No |
| 10 | CORT | NA | CORT Entrez, Source | cortistatin | 4282 | 0.910 | 0.1919 | No |
| 11 | GRM8 | NA | GRM8 Entrez, Source | glutamate receptor, metabotropic 8 | 4367 | 0.891 | 0.2072 | No |
| 12 | GRM2 | NA | GRM2 Entrez, Source | glutamate receptor, metabotropic 2 | 4527 | 0.855 | 0.2190 | No |
| 13 | OPRL1 | NA | OPRL1 Entrez, Source | opiate receptor-like 1 | 5330 | 0.654 | 0.2031 | No |
| 14 | GALR3 | NA | GALR3 Entrez, Source | galanin receptor 3 | 7800 | 0.318 | 0.1191 | No |
| 15 | DRD1 | NA | DRD1 Entrez, Source | dopamine receptor D1 | 7969 | 0.303 | 0.1192 | No |
| 16 | ADRA1D | NA | ADRA1D Entrez, Source | adrenergic, alpha-1D-, receptor | 8136 | 0.289 | 0.1191 | No |
| 17 | GHRH | NA | GHRH Entrez, Source | growth hormone releasing hormone | 8998 | 0.230 | 0.0922 | No |
| 18 | WASF2 | NA | WASF2 Entrez, Source | WAS protein family, member 2 | 9505 | 0.203 | 0.0779 | No |
| 19 | FPR1 | NA | FPR1 Entrez, Source | formyl peptide receptor 1 | 9604 | 0.197 | 0.0784 | No |
| 20 | GALR2 | NA | GALR2 Entrez, Source | galanin receptor 2 | 10300 | 0.165 | 0.0563 | No |
| 21 | ADRB3 | NA | ADRB3 Entrez, Source | adrenergic, beta-3-, receptor | 10525 | 0.155 | 0.0513 | No |
| 22 | DRD5 | NA | DRD5 Entrez, Source | dopamine receptor D5 | 10739 | 0.144 | 0.0464 | No |
| 23 | GABBR1 | NA | GABBR1 Entrez, Source | gamma-aminobutyric acid (GABA) B receptor, 1 | 12674 | 0.065 | -0.0232 | No |
| 24 | CCR3 | NA | CCR3 Entrez, Source | chemokine (C-C motif) receptor 3 | 13040 | 0.051 | -0.0355 | No |
| 25 | ADCYAP1 | NA | ADCYAP1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) | 13232 | 0.044 | -0.0416 | No |
| 26 | ADORA3 | NA | ADORA3 Entrez, Source | adenosine A3 receptor | 13509 | 0.033 | -0.0511 | No |
| 27 | AVPR2 | NA | AVPR2 Entrez, Source | arginine vasopressin receptor 2 (nephrogenic diabetes insipidus) | 13934 | 0.017 | -0.0662 | No |
| 28 | OPRK1 | NA | OPRK1 Entrez, Source | opioid receptor, kappa 1 | 14020 | 0.014 | -0.0691 | No |
| 29 | GRM7 | NA | GRM7 Entrez, Source | glutamate receptor, metabotropic 7 | 14274 | 0.005 | -0.0782 | No |
| 30 | ADRA2A | NA | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 14312 | 0.004 | -0.0795 | No |
| 31 | GNAI3 | NA | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 14360 | 0.002 | -0.0812 | No |
| 32 | MC4R | NA | MC4R Entrez, Source | melanocortin 4 receptor | 14542 | -0.004 | -0.0878 | No |
| 33 | LTB4R2 | NA | LTB4R2 Entrez, Source | leukotriene B4 receptor 2 | 14863 | -0.015 | -0.0992 | No |
| 34 | CALCA | NA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 15001 | -0.021 | -0.1038 | No |
| 35 | CALCR | NA | CALCR Entrez, Source | calcitonin receptor | 15077 | -0.024 | -0.1060 | No |
| 36 | GALR1 | NA | GALR1 Entrez, Source | galanin receptor 1 | 15493 | -0.040 | -0.1204 | No |
| 37 | GHRHR | NA | GHRHR Entrez, Source | growth hormone releasing hormone receptor | 15734 | -0.050 | -0.1282 | No |
| 38 | GRM3 | NA | GRM3 Entrez, Source | glutamate receptor, metabotropic 3 | 15804 | -0.052 | -0.1296 | No |
| 39 | NPY2R | NA | NPY2R Entrez, Source | neuropeptide Y receptor Y2 | 16025 | -0.061 | -0.1364 | No |
| 40 | CCR2 | NA | CCR2 Entrez, Source | chemokine (C-C motif) receptor 2 | 16547 | -0.083 | -0.1538 | No |
| 41 | ACR | NA | ACR Entrez, Source | acrosin | 17204 | -0.111 | -0.1756 | No |
| 42 | GLP1R | NA | GLP1R Entrez, Source | glucagon-like peptide 1 receptor | 17245 | -0.112 | -0.1748 | No |
| 43 | GIPR | NA | GIPR Entrez, Source | gastric inhibitory polypeptide receptor | 18335 | -0.174 | -0.2111 | No |
| 44 | CHRM5 | NA | CHRM5 Entrez, Source | cholinergic receptor, muscarinic 5 | 18788 | -0.209 | -0.2234 | No |
| 45 | EDNRA | NA | EDNRA Entrez, Source | endothelin receptor type A | 18830 | -0.212 | -0.2205 | No |
| 46 | CHRM2 | NA | CHRM2 Entrez, Source | cholinergic receptor, muscarinic 2 | 18841 | -0.213 | -0.2165 | No |
| 47 | GCGR | NA | GCGR Entrez, Source | glucagon receptor | 19329 | -0.253 | -0.2291 | No |
| 48 | GLP2R | NA | GLP2R Entrez, Source | glucagon-like peptide 2 receptor | 19551 | -0.275 | -0.2315 | No |
| 49 | CRHR2 | NA | CRHR2 Entrez, Source | corticotropin releasing hormone receptor 2 | 20059 | -0.327 | -0.2434 | No |
| 50 | CAP1 | NA | CAP1 Entrez, Source | CAP, adenylate cyclase-associated protein 1 (yeast) | 20201 | -0.341 | -0.2415 | No |
| 51 | GRM4 | NA | GRM4 Entrez, Source | glutamate receptor, metabotropic 4 | 20203 | -0.342 | -0.2345 | No |
| 52 | NPY1R | NA | NPY1R Entrez, Source | neuropeptide Y receptor Y1 | 20294 | -0.354 | -0.2305 | No |
| 53 | GPR3 | NA | GPR3 Entrez, Source | G protein-coupled receptor 3 | 20303 | -0.356 | -0.2234 | No |
| 54 | P2RY11 | NA | P2RY11 Entrez, Source | purinergic receptor P2Y, G-protein coupled, 11 | 20648 | -0.399 | -0.2278 | No |
| 55 | RGS1 | NA | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 20995 | -0.451 | -0.2312 | No |
| 56 | CRHR1 | NA | CRHR1 Entrez, Source | corticotropin releasing hormone receptor 1 | 22759 | -0.786 | -0.2796 | No |
| 57 | NF1 | NA | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 25328 | -1.560 | -0.3416 | Yes |
| 58 | ADCY7 | NA | ADCY7 Entrez, Source | adenylate cyclase 7 | 25733 | -1.754 | -0.3202 | Yes |
| 59 | ADRA1B | NA | ADRA1B Entrez, Source | adrenergic, alpha-1B-, receptor | 26004 | -1.917 | -0.2905 | Yes |
| 60 | PTHLH | NA | PTHLH Entrez, Source | parathyroid hormone-like hormone | 26693 | -2.489 | -0.2643 | Yes |
| 61 | ADRB1 | NA | ADRB1 Entrez, Source | adrenergic, beta-1-, receptor | 26938 | -2.889 | -0.2136 | Yes |
| 62 | ADRB2 | NA | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 27138 | -3.500 | -0.1487 | Yes |
| 63 | ADORA2B | NA | ADORA2B Entrez, Source | adenosine A2b receptor | 27155 | -3.561 | -0.0757 | Yes |
| 64 | PTGER4 | NA | PTGER4 Entrez, Source | prostaglandin E receptor 4 (subtype EP4) | 27226 | -3.974 | 0.0038 | Yes |
