Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | IMMUNE_SYSTEM_DEVELOPMENT |
| Enrichment Score (ES) | -0.40270084 |
| Normalized Enrichment Score (NES) | -1.5547444 |
| Nominal p-value | 0.012448133 |
| FDR q-value | 0.15815729 |
| FWER p-Value | 0.659 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HDAC5 | NA | HDAC5 Entrez, Source | histone deacetylase 5 | 620 | 2.653 | 0.0185 | No |
| 2 | CDK6 | NA | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 774 | 2.496 | 0.0517 | No |
| 3 | RAG1 | NA | RAG1 Entrez, Source | recombination activating gene 1 | 842 | 2.440 | 0.0872 | No |
| 4 | NOTCH4 | NA | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 877 | 2.408 | 0.1234 | No |
| 5 | ZBTB16 | NA | ZBTB16 Entrez, Source | zinc finger and BTB domain containing 16 | 1236 | 2.142 | 0.1436 | No |
| 6 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 2909 | 1.346 | 0.1032 | No |
| 7 | NCOA6 | NA | NCOA6 Entrez, Source | nuclear receptor coactivator 6 | 3451 | 1.168 | 0.1015 | No |
| 8 | RUNX1 | NA | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 3716 | 1.078 | 0.1086 | No |
| 9 | ZNF675 | NA | ZNF675 Entrez, Source | zinc finger protein 675 | 4070 | 0.967 | 0.1107 | No |
| 10 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4414 | 0.880 | 0.1118 | No |
| 11 | KIRREL3 | NA | KIRREL3 Entrez, Source | kin of IRRE like 3 (Drosophila) | 4586 | 0.843 | 0.1186 | No |
| 12 | MAFB | NA | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 5115 | 0.716 | 0.1104 | No |
| 13 | CD3D | NA | CD3D Entrez, Source | CD3d molecule, delta (CD3-TCR complex) | 5535 | 0.610 | 0.1045 | No |
| 14 | LDB1 | NA | LDB1 Entrez, Source | LIM domain binding 1 | 6304 | 0.481 | 0.0838 | No |
| 15 | CDC42 | NA | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 6315 | 0.479 | 0.0909 | No |
| 16 | ACVR2A | NA | ACVR2A Entrez, Source | activin A receptor, type IIA | 6330 | 0.476 | 0.0978 | No |
| 17 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 6852 | 0.412 | 0.0851 | No |
| 18 | MLL | NA | MLL Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 7425 | 0.351 | 0.0695 | No |
| 19 | CD79A | NA | CD79A Entrez, Source | CD79a molecule, immunoglobulin-associated alpha | 7709 | 0.325 | 0.0642 | No |
| 20 | LRMP | NA | LRMP Entrez, Source | lymphoid-restricted membrane protein | 8098 | 0.292 | 0.0545 | No |
| 21 | HDAC9 | NA | HDAC9 Entrez, Source | histone deacetylase 9 | 8162 | 0.287 | 0.0567 | No |
| 22 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 8575 | 0.258 | 0.0455 | No |
| 23 | FOXO3 | NA | 8956 | 0.232 | 0.0352 | No | ||
| 24 | MAL | NA | MAL Entrez, Source | mal, T-cell differentiation protein | 8971 | 0.232 | 0.0383 | No |
| 25 | SCIN | NA | SCIN Entrez, Source | scinderin | 9244 | 0.216 | 0.0317 | No |
| 26 | INHA | NA | INHA Entrez, Source | inhibin, alpha | 9461 | 0.205 | 0.0270 | No |
| 27 | SNRK | NA | SNRK Entrez, Source | SNF related kinase | 9984 | 0.179 | 0.0106 | No |
| 28 | HDAC4 | NA | HDAC4 Entrez, Source | histone deacetylase 4 | 10190 | 0.170 | 0.0057 | No |
| 29 | CD4 | NA | CD4 Entrez, Source | CD4 molecule | 10391 | 0.161 | 0.0009 | No |
| 30 | TM7SF4 | NA | TM7SF4 Entrez, Source | transmembrane 7 superfamily member 4 | 10640 | 0.150 | -0.0059 | No |
| 31 | LIG1 | NA | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 10886 | 0.138 | -0.0127 | No |
| 32 | BLNK | NA | BLNK Entrez, Source | B-cell linker | 11083 | 0.128 | -0.0179 | No |
| 33 | INHBA | NA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 11814 | 0.097 | -0.0432 | No |
| 34 | IL4 | NA | IL4 Entrez, Source | interleukin 4 | 12003 | 0.090 | -0.0487 | No |
| 35 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 12329 | 0.078 | -0.0594 | No |
| 36 | SPINK5 | NA | SPINK5 Entrez, Source | serine peptidase inhibitor, Kazal type 5 | 12331 | 0.078 | -0.0583 | No |
| 37 | TAZ | NA | TAZ Entrez, Source | tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) | 12468 | 0.072 | -0.0621 | No |
| 38 | RASGRP4 | NA | RASGRP4 Entrez, Source | RAS guanyl releasing protein 4 | 13385 | 0.038 | -0.0951 | No |
| 39 | SPI1 | NA | SPI1 Entrez, Source | spleen focus forming virus (SFFV) proviral integration oncogene spi1 | 13822 | 0.021 | -0.1108 | No |
| 40 | CARTPT | NA | CARTPT Entrez, Source | CART prepropeptide | 14067 | 0.012 | -0.1196 | No |
| 41 | CALCA | NA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 15001 | -0.021 | -0.1535 | No |
| 42 | CD1D | NA | CD1D Entrez, Source | CD1d molecule | 15044 | -0.023 | -0.1547 | No |
| 43 | PF4 | NA | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 15523 | -0.042 | -0.1716 | No |
| 44 | SART1 | NA | SART1 Entrez, Source | squamous cell carcinoma antigen recognised by T cells | 15650 | -0.046 | -0.1755 | No |
| 45 | PTPRC | NA | PTPRC Entrez, Source | protein tyrosine phosphatase, receptor type, C | 15992 | -0.059 | -0.1871 | No |
| 46 | ZAP70 | NA | ZAP70 Entrez, Source | zeta-chain (TCR) associated protein kinase 70kDa | 16072 | -0.063 | -0.1890 | No |
| 47 | IL27 | NA | IL27 Entrez, Source | interleukin 27 | 16712 | -0.090 | -0.2110 | No |
| 48 | NFAM1 | NA | NFAM1 Entrez, Source | NFAT activating protein with ITAM motif 1 | 16832 | -0.094 | -0.2139 | No |
| 49 | CD40LG | NA | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 17229 | -0.112 | -0.2267 | No |
| 50 | ACVR1B | NA | ACVR1B Entrez, Source | activin A receptor, type IB | 17427 | -0.121 | -0.2321 | No |
| 51 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 17510 | -0.125 | -0.2331 | No |
| 52 | PRL | NA | PRL Entrez, Source | prolactin | 18243 | -0.168 | -0.2574 | No |
| 53 | MAP4K1 | NA | MAP4K1 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 1 | 18558 | -0.189 | -0.2660 | No |
| 54 | HCLS1 | NA | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 18598 | -0.193 | -0.2644 | No |
| 55 | ALAS2 | NA | ALAS2 Entrez, Source | aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | 18816 | -0.211 | -0.2691 | No |
| 56 | LCK | NA | LCK Entrez, Source | lymphocyte-specific protein tyrosine kinase | 19426 | -0.263 | -0.2873 | No |
| 57 | HDAC7 | NA | 19453 | -0.265 | -0.2842 | No | ||
| 58 | ACIN1 | NA | ACIN1 Entrez, Source | apoptotic chromatin condensation inducer 1 | 20628 | -0.396 | -0.3211 | No |
| 59 | RPS19 | NA | RPS19 Entrez, Source | ribosomal protein S19 | 20905 | -0.438 | -0.3244 | No |
| 60 | NHEJ1 | NA | NHEJ1 Entrez, Source | nonhomologous end-joining factor 1 | 21740 | -0.579 | -0.3460 | No |
| 61 | TNFSF13 | NA | TNFSF13 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 13 | 22312 | -0.689 | -0.3562 | No |
| 62 | RAB3D | NA | RAB3D Entrez, Source | RAB3D, member RAS oncogene family | 22371 | -0.700 | -0.3475 | No |
| 63 | MLF1 | NA | MLF1 Entrez, Source | myeloid leukemia factor 1 | 23877 | -1.059 | -0.3862 | Yes |
| 64 | LIG3 | NA | LIG3 Entrez, Source | ligase III, DNA, ATP-dependent | 24016 | -1.093 | -0.3743 | Yes |
| 65 | IL31RA | NA | IL31RA Entrez, Source | interleukin 31 receptor A | 24163 | -1.138 | -0.3619 | Yes |
| 66 | ETS1 | NA | ETS1 Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 24224 | -1.157 | -0.3461 | Yes |
| 67 | CEBPG | NA | CEBPG Entrez, Source | CCAAT/enhancer binding protein (C/EBP), gamma | 24481 | -1.238 | -0.3363 | Yes |
| 68 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 24608 | -1.278 | -0.3210 | Yes |
| 69 | JAG2 | NA | JAG2 Entrez, Source | jagged 2 | 25070 | -1.447 | -0.3154 | Yes |
| 70 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 25971 | -1.898 | -0.3190 | Yes |
| 71 | TPD52 | NA | TPD52 Entrez, Source | tumor protein D52 | 26053 | -1.952 | -0.2916 | Yes |
| 72 | MYH9 | NA | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 26135 | -2.006 | -0.2633 | Yes |
| 73 | SOCS5 | NA | SOCS5 Entrez, Source | suppressor of cytokine signaling 5 | 26188 | -2.049 | -0.2334 | Yes |
| 74 | IFI16 | NA | IFI16 Entrez, Source | interferon, gamma-inducible protein 16 | 26475 | -2.276 | -0.2085 | Yes |
| 75 | MAP4K2 | NA | MAP4K2 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 2 | 26664 | -2.459 | -0.1771 | Yes |
| 76 | DYRK3 | NA | DYRK3 Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 26772 | -2.601 | -0.1406 | Yes |
| 77 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 26962 | -2.930 | -0.1020 | Yes |
| 78 | LYN | NA | LYN Entrez, Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 27040 | -3.155 | -0.0557 | Yes |
| 79 | TBX1 | NA | TBX1 Entrez, Source | T-box 1 | 27264 | -4.262 | 0.0024 | Yes |
