Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | NEGATIVE_REGULATION_OF_GROWTH |
| Enrichment Score (ES) | 0.5134804 |
| Normalized Enrichment Score (NES) | 1.6421329 |
| Nominal p-value | 0.008583691 |
| FDR q-value | 0.07351936 |
| FWER p-Value | 0.438 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | BCL6 | NA | BCL6 Entrez, Source | B-cell CLL/lymphoma 6 (zinc finger protein 51) | 45 | 3.695 | 0.0719 | Yes |
| 2 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 67 | 3.588 | 0.1425 | Yes |
| 3 | CDKN2C | NA | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 93 | 3.507 | 0.2114 | Yes |
| 4 | ING5 | NA | ING5 Entrez, Source | inhibitor of growth family, member 5 | 238 | 3.199 | 0.2698 | Yes |
| 5 | RB1 | NA | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 324 | 3.044 | 0.3272 | Yes |
| 6 | IP6K2 | NA | 420 | 2.902 | 0.3815 | Yes | ||
| 7 | PPT1 | NA | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 1566 | 1.942 | 0.3782 | Yes |
| 8 | APBB2 | NA | APBB2 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) | 1627 | 1.909 | 0.4140 | Yes |
| 9 | ING4 | NA | ING4 Entrez, Source | inhibitor of growth family, member 4 | 2213 | 1.629 | 0.4250 | Yes |
| 10 | APBB1 | NA | APBB1 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 2642 | 1.447 | 0.4381 | Yes |
| 11 | NDUFA13 | NA | NDUFA13 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 | 2660 | 1.440 | 0.4661 | Yes |
| 12 | PTCH1 | NA | PTCH1 Entrez, Source | patched homolog 1 (Drosophila) | 3164 | 1.252 | 0.4726 | Yes |
| 13 | CDKN1A | NA | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3168 | 1.250 | 0.4974 | Yes |
| 14 | SMAD4 | NA | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 3377 | 1.191 | 0.5135 | Yes |
| 15 | SMAD3 | NA | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 4089 | 0.962 | 0.5066 | No |
| 16 | CDKN2D | NA | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 5634 | 0.590 | 0.4617 | No |
| 17 | CDKN2A | NA | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 5692 | 0.579 | 0.4712 | No |
| 18 | BMP10 | NA | BMP10 Entrez, Source | bone morphogenetic protein 10 | 7067 | 0.390 | 0.4286 | No |
| 19 | NDUFS3 | NA | NDUFS3 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) | 7677 | 0.327 | 0.4128 | No |
| 20 | SERTAD2 | NA | SERTAD2 Entrez, Source | SERTA domain containing 2 | 8100 | 0.292 | 0.4032 | No |
| 21 | PPP1R9B | NA | PPP1R9B Entrez, Source | protein phosphatase 1, regulatory subunit 9B, spinophilin | 9535 | 0.201 | 0.3546 | No |
| 22 | SERTAD3 | NA | SERTAD3 Entrez, Source | SERTA domain containing 3 | 10194 | 0.170 | 0.3339 | No |
| 23 | BBC3 | NA | BBC3 Entrez, Source | BCL2 binding component 3 | 10553 | 0.153 | 0.3238 | No |
| 24 | INHBA | NA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 11814 | 0.097 | 0.2796 | No |
| 25 | OSGIN1 | NA | OSGIN1 Entrez, Source | oxidative stress induced growth inhibitor 1 | 13198 | 0.045 | 0.2298 | No |
| 26 | ALOX15B | NA | ALOX15B Entrez, Source | arachidonate 15-lipoxygenase, type B | 14038 | 0.013 | 0.1993 | No |
| 27 | ACVR1B | NA | ACVR1B Entrez, Source | activin A receptor, type IB | 17427 | -0.121 | 0.0776 | No |
| 28 | CDA | NA | CDA Entrez, Source | cytidine deaminase | 18644 | -0.197 | 0.0370 | No |
| 29 | TSPYL2 | NA | TSPYL2 Entrez, Source | TSPY-like 2 | 19691 | -0.288 | 0.0044 | No |
| 30 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 21656 | -0.561 | -0.0564 | No |
| 31 | KLK8 | NA | KLK8 Entrez, Source | kallikrein 8 (neuropsin/ovasin) | 22369 | -0.699 | -0.0686 | No |
| 32 | DCBLD2 | NA | DCBLD2 Entrez, Source | discoidin, CUB and LCCL domain containing 2 | 22793 | -0.793 | -0.0683 | No |
| 33 | CDKN2AIP | NA | 22981 | -0.836 | -0.0585 | No | ||
| 34 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 24608 | -1.278 | -0.0927 | No |
| 35 | PML | NA | PML Entrez, Source | promyelocytic leukemia | 24699 | -1.310 | -0.0699 | No |
| 36 | CAPRIN2 | NA | 25196 | -1.499 | -0.0582 | No | ||
| 37 | DLC1 | NA | DLC1 Entrez, Source | deleted in liver cancer 1 | 25743 | -1.761 | -0.0432 | No |
| 38 | ENO1 | NA | ENO1 Entrez, Source | enolase 1, (alpha) | 25895 | -1.853 | -0.0118 | No |
| 39 | RERG | NA | RERG Entrez, Source | RAS-like, estrogen-regulated, growth inhibitor | 27069 | -3.233 | 0.0095 | No |
