Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | REGULATION_OF_IMMUNE_RESPONSE |
| Enrichment Score (ES) | 0.57175815 |
| Normalized Enrichment Score (NES) | 2.051445 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.002375261 |
| FWER p-Value | 0.004 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | THY1 | NA | THY1 Entrez, Source | Thy-1 cell surface antigen | 240 | 3.194 | 0.1386 | Yes |
| 2 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 290 | 3.102 | 0.2799 | Yes |
| 3 | CADM1 | NA | 317 | 3.053 | 0.4197 | Yes | ||
| 4 | UBE2N | NA | UBE2N Entrez, Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 1299 | 2.102 | 0.4807 | Yes |
| 5 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 1389 | 2.044 | 0.5718 | Yes |
| 6 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4414 | 0.880 | 0.5016 | No |
| 7 | CD79A | NA | CD79A Entrez, Source | CD79a molecule, immunoglobulin-associated alpha | 7709 | 0.325 | 0.3959 | No |
| 8 | FOXP3 | NA | FOXP3 Entrez, Source | forkhead box P3 | 8420 | 0.268 | 0.3823 | No |
| 9 | MALT1 | NA | MALT1 Entrez, Source | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 9281 | 0.215 | 0.3607 | No |
| 10 | MBL2 | NA | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 9779 | 0.189 | 0.3512 | No |
| 11 | IL29 | NA | IL29 Entrez, Source | interleukin 29 (interferon, lambda 1) | 9835 | 0.186 | 0.3578 | No |
| 12 | SLA2 | NA | SLA2 Entrez, Source | Src-like-adaptor 2 | 10157 | 0.172 | 0.3539 | No |
| 13 | TLR8 | NA | TLR8 Entrez, Source | toll-like receptor 8 | 10189 | 0.171 | 0.3607 | No |
| 14 | IFNK | NA | IFNK Entrez, Source | interferon, kappa | 11455 | 0.112 | 0.3195 | No |
| 15 | IL4 | NA | IL4 Entrez, Source | interleukin 4 | 12003 | 0.090 | 0.3036 | No |
| 16 | TRAT1 | NA | TRAT1 Entrez, Source | T cell receptor associated transmembrane adaptor 1 | 12290 | 0.080 | 0.2968 | No |
| 17 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 12329 | 0.078 | 0.2990 | No |
| 18 | SPINK5 | NA | SPINK5 Entrez, Source | serine peptidase inhibitor, Kazal type 5 | 12331 | 0.078 | 0.3025 | No |
| 19 | LAT2 | NA | LAT2 Entrez, Source | linker for activation of T cells family, member 2 | 13288 | 0.042 | 0.2694 | No |
| 20 | C2 | NA | C2 Entrez, Source | complement component 2 | 13410 | 0.037 | 0.2667 | No |
| 21 | KRT1 | NA | KRT1 Entrez, Source | keratin 1 (epidermolytic hyperkeratosis) | 14206 | 0.008 | 0.2379 | No |
| 22 | CD1D | NA | CD1D Entrez, Source | CD1d molecule | 15044 | -0.023 | 0.2083 | No |
| 23 | CRTAM | NA | CRTAM Entrez, Source | cytotoxic and regulatory T cell molecule | 15421 | -0.038 | 0.1963 | No |
| 24 | PTPRC | NA | PTPRC Entrez, Source | protein tyrosine phosphatase, receptor type, C | 15992 | -0.059 | 0.1781 | No |
| 25 | CFHR1 | NA | CFHR1 Entrez, Source | complement factor H-related 1 | 16434 | -0.079 | 0.1656 | No |
| 26 | NFAM1 | NA | NFAM1 Entrez, Source | NFAT activating protein with ITAM motif 1 | 16832 | -0.094 | 0.1554 | No |
| 27 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 17316 | -0.116 | 0.1431 | No |
| 28 | NCR1 | NA | NCR1 Entrez, Source | natural cytotoxicity triggering receptor 1 | 17671 | -0.132 | 0.1362 | No |
| 29 | EREG | NA | EREG Entrez, Source | epiregulin | 19078 | -0.233 | 0.0954 | No |
| 30 | IL12A | NA | IL12A Entrez, Source | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 20579 | -0.390 | 0.0585 | No |
| 31 | TRAF2 | NA | TRAF2 Entrez, Source | TNF receptor-associated factor 2 | 20608 | -0.393 | 0.0756 | No |
| 32 | BCAR1 | NA | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 23839 | -1.047 | 0.0056 | No |
| 33 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 26801 | -2.650 | 0.0193 | No |
