Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | REGULATION_OF_ORGANELLE_ORGANIZATION_AND_BIOGENESIS |
| Enrichment Score (ES) | 0.5705646 |
| Normalized Enrichment Score (NES) | 1.634762 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0757108 |
| FWER p-Value | 0.461 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MAPT | NA | MAPT Entrez, Source | microtubule-associated protein tau | 96 | 3.498 | 0.0726 | Yes |
| 2 | PPARGC1A | NA | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 136 | 3.387 | 0.1448 | Yes |
| 3 | NF2 | NA | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 341 | 3.010 | 0.2028 | Yes |
| 4 | NCK2 | NA | NCK2 Entrez, Source | NCK adaptor protein 2 | 415 | 2.906 | 0.2633 | Yes |
| 5 | LIMA1 | NA | LIMA1 Entrez, Source | LIM domain and actin binding 1 | 617 | 2.658 | 0.3138 | Yes |
| 6 | ARHGEF10L | NA | ARHGEF10L Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 10-like | 1038 | 2.291 | 0.3482 | Yes |
| 7 | UBE2N | NA | UBE2N Entrez, Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 1299 | 2.102 | 0.3844 | Yes |
| 8 | TERF2IP | NA | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 1813 | 1.815 | 0.4051 | Yes |
| 9 | GSN | NA | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 1877 | 1.789 | 0.4417 | Yes |
| 10 | CLASP1 | NA | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 2249 | 1.618 | 0.4633 | Yes |
| 11 | CDC42EP5 | NA | CDC42EP5 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 5 | 3136 | 1.262 | 0.4583 | Yes |
| 12 | CCDC88A | NA | 3229 | 1.232 | 0.4817 | Yes | ||
| 13 | TLK1 | NA | TLK1 Entrez, Source | tousled-like kinase 1 | 3559 | 1.135 | 0.4943 | Yes |
| 14 | SET | NA | SET Entrez, Source | SET translocation (myeloid leukemia-associated) | 4091 | 0.961 | 0.4958 | Yes |
| 15 | ARHGEF2 | NA | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 4346 | 0.896 | 0.5060 | Yes |
| 16 | CLASP2 | NA | CLASP2 Entrez, Source | cytoplasmic linker associated protein 2 | 4347 | 0.895 | 0.5254 | Yes |
| 17 | TSC1 | NA | TSC1 Entrez, Source | tuberous sclerosis 1 | 4433 | 0.875 | 0.5414 | Yes |
| 18 | CAPG | NA | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 4876 | 0.772 | 0.5420 | Yes |
| 19 | CRIPAK | NA | CRIPAK Entrez, Source | cysteine-rich PAK1 inhibitor | 4975 | 0.748 | 0.5546 | Yes |
| 20 | TLK2 | NA | TLK2 Entrez, Source | tousled-like kinase 2 | 4984 | 0.746 | 0.5706 | Yes |
| 21 | APC | NA | APC Entrez, Source | adenomatosis polyposis coli | 5427 | 0.632 | 0.5681 | No |
| 22 | NCK1 | NA | NCK1 Entrez, Source | NCK adaptor protein 1 | 6863 | 0.412 | 0.5245 | No |
| 23 | SORBS3 | NA | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 7063 | 0.391 | 0.5257 | No |
| 24 | MID1IP1 | NA | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 10372 | 0.162 | 0.4080 | No |
| 25 | ERCC4 | NA | ERCC4 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 4 | 12069 | 0.088 | 0.3478 | No |
| 26 | ARF6 | NA | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 13142 | 0.047 | 0.3095 | No |
| 27 | TMSB4Y | NA | TMSB4Y Entrez, Source | thymosin, beta 4, Y-linked | 16657 | -0.087 | 0.1826 | No |
| 28 | CXCL12 | NA | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 17216 | -0.111 | 0.1646 | No |
| 29 | LATS1 | NA | LATS1 Entrez, Source | LATS, large tumor suppressor, homolog 1 (Drosophila) | 19021 | -0.229 | 0.1035 | No |
| 30 | PIF1 | NA | 19325 | -0.253 | 0.0979 | No | ||
| 31 | NEBL | NA | NEBL Entrez, Source | nebulette | 19813 | -0.301 | 0.0866 | No |
| 32 | MAPRE1 | NA | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 20611 | -0.394 | 0.0659 | No |
| 33 | RASA1 | NA | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 21094 | -0.467 | 0.0584 | No |
| 34 | ARAP1 | NA | 21410 | -0.516 | 0.0581 | No | ||
| 35 | CEP250 | NA | CEP250 Entrez, Source | centrosomal protein 250kDa | 22350 | -0.696 | 0.0388 | No |
| 36 | ERCC1 | NA | ERCC1 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | 22926 | -0.824 | 0.0357 | No |
| 37 | TERF2 | NA | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 23315 | -0.905 | 0.0411 | No |
| 38 | KATNB1 | NA | KATNB1 Entrez, Source | katanin p80 (WD repeat containing) subunit B 1 | 23497 | -0.951 | 0.0552 | No |
| 39 | CDC42EP2 | NA | CDC42EP2 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 2 | 24413 | -1.214 | 0.0481 | No |
| 40 | NEXN | NA | NEXN Entrez, Source | nexilin (F actin binding protein) | 26829 | -2.701 | 0.0183 | No |
